Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis

British Journal of Pharmacology

Volumn 170, Issue 1, 2013, Pages 67-77

  Ballerini, C ^a   Aldinucci, A ^a   Luccarini, I ^a   Galante, A ^a   Manuelli, C ^a   Blandina, P ^a   Katebe, M ^b   Chazot, P L ^b   Masini, E ^a   Passani, M B ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

autoimmune diseases; histamine receptors; histamine system; inflammation; JNJ7777120; multiple sclerosis

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; ANTIBODY; GAMMA INTERFERON; HISTAMINE H4 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 7; MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY; THYMIDINE; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; TRITIUM; UNCLASSIFIED DRUG; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; ANTIHISTAMINIC AGENT; CYTOKINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PIPERAZINE DERIVATIVE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL INFILTRATION; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; DISEASE EXACERBATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HISTOPATHOLOGY; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MOUSE; MYELITIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA ANALYSIS; T LYMPHOCYTE; ANIMAL; AUTOIMMUNE DISEASE; C57BL MOUSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION REGULATION; HISTAMINE RECEPTORS; HISTAMINE SYSTEM; INFLAMMATION; METABOLISM; MULTIPLE SCLEROSIS; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

AUTOIMMUNE DISEASES; HISTAMINE RECEPTORS; HISTAMINE SYSTEM; INFLAMMATION; JNJ7777120; MULTIPLE SCLEROSIS;

ANIMALS; ANTIBODY FORMATION; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTAMINE ANTAGONISTS; INDOLES; INFLAMMATION; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PIPERAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES;

EID: 84881640708     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12263     Document Type: Article

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