-
1
-
-
0032697674
-
The antihy perglycaemic ef fect of metformin: Therapeutic and cellular mechanisms
-
Wiernsperger NF, Bailey CJ. The antihy perglycaemic effect of metformin: therapeutic and cellular mechanisms. Drugs, 1999, 58(Suppl 1): 31-39, 75-82.
-
(1999)
Drugs
, vol.58
, Issue.SUPPL 1
-
-
Wiernsperger, N.F.1
Bailey, C.J.2
-
2
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, et al. Metformin and reduced risk of cancer in diabetic patients. BMJ, 2005, 330(7503): 1304-1305.
-
(2005)
BMJ
, vol.330
, Issue.7503
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
-
3
-
-
84875303678
-
Metformin and cancer
-
Rizos CV, Elisaf MS. Metformin and cancer. Eur J Pharmacol, 2013, 705(1-3): 96-108.
-
(2013)
Eur J Pharmacol
, vol.705
, Issue.1-3
, pp. 96-108
-
-
Rizos, C.V.1
Elisaf, M.S.2
-
4
-
-
77956415337
-
Metformin prevents tobacco carcinogen--induced lung tumorigenesis
-
Memmott RM, Mercado JR, Maier CR, et al. Metformin prevents tobacco carcinogen--induced lung tumorigenesis. Cancer Prev Res (Phila), 2010, 3(9): 1066-1076.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, Issue.9
, pp. 1066-1076
-
-
Memmott, R.M.1
Mercado, J.R.2
Maier, C.R.3
-
5
-
-
84858719140
-
Metformin as an energy restriction mimetic agent for breast cancer prevention
-
Zhu Z, Jiang W, Thompson MD, et al. Metformin as an energy restriction mimetic agent for breast cancer prevention. J Carcinog, 2011, 10: 17.
-
(2011)
J Carcinog
, vol.10
, pp. 17
-
-
Zhu, Z.1
Jiang, W.2
Thompson, M.D.3
-
6
-
-
84863601615
-
Metformin for liver cancer prevention in patients with type 2 diabetes: A systematic review and meta-analysis
-
Zhang ZJ, Zheng ZJ, Shi R, et al. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab, 2012, 97(7): 2347-2353.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.7
, pp. 2347-2353
-
-
Zhang, Z.J.1
Zheng, Z.J.2
Shi, R.3
-
7
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol, 2007, 8(10): 774-785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.10
, pp. 774-785
-
-
Hardie, D.G.1
-
8
-
-
50049105823
-
The regulation of AMP-activated protein kinase by upstream kinases
-
Carling D, Sanders MJ, Woods A. The regulation of AMP-activated protein kinase by upstream kinases. Int J Obes (Lond), 2008, 32(Suppl 4): S55-S59.
-
(2008)
Int J Obes (Lond)
, vol.32
, Issue.SUPPL. 4
-
-
Carling, D.1
Sanders, M.J.2
Woods, A.3
-
9
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
-
El-Mir MY, Nogueira V, Fontaine E, et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem, 2000, 275(1): 223-228.
-
(2000)
J Biol Chem
, vol.275
, Issue.1
, pp. 223-228
-
-
El-Mir, M.Y.1
Nogueira, V.2
Fontaine, E.3
-
10
-
-
79953661884
-
Understanding the benefit of metformin use in cancer treatment
-
Dowling RJ, Goodwin PJ, Stambolic V. Understanding the benefit of metformin use in cancer treatment. BMC Med, 2011, 9: 33.
-
(2011)
BMC Med
, vol.9
, pp. 33
-
-
Dowling, R.J.1
Goodwin, P.J.2
Stambolic, V.3
-
11
-
-
0036324142
-
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
-
Hawley SA, Gadalla AE, Olsen GS, et al. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes, 2002, 51(8): 2420-2425.
-
(2002)
Diabetes
, vol.51
, Issue.8
, pp. 2420-2425
-
-
Hawley, S.A.1
Gadalla, A.E.2
Olsen, G.S.3
-
12
-
-
84864369594
-
Metformin interacts with AMPK through binding to gamma subunit
-
Zhang Y, Wang Y, Bao C, et al. Metformin interacts with AMPK through binding to gamma subunit. Mol Cell Biochem, 2012, 368(1-2): 69-76.
-
(2012)
Mol Cell Biochem
, vol.368
, Issue.1-2
, pp. 69-76
-
-
Zhang, Y.1
Wang, Y.2
Bao, C.3
-
13
-
-
77949462458
-
AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth
-
Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 2010, 6(3): 457-470.
-
(2010)
Future Oncol
, vol.6
, Issue.3
, pp. 457-470
-
-
Luo, Z.1
Zang, M.2
Guo, W.3
-
14
-
-
84865685190
-
Metformin impairs the growth of liver kinase B1-intact cervical cancer cells
-
Xiao X, He Q, Lu C, et al. Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. Gynecol Oncol, 2012, 127(1): 249-255.
-
(2012)
Gynecol Oncol
, vol.127
, Issue.1
, pp. 249-255
-
-
Xiao, X.1
He, Q.2
Lu, C.3
-
15
-
-
33847080728
-
AMP-activated protein kinase in metabolic control and insulin signaling
-
Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res, 2007, 100(3): 328-341.
-
(2007)
Circ Res
, vol.100
, Issue.3
, pp. 328-341
-
-
Towler, M.C.1
Hardie, D.G.2
-
16
-
-
84876526130
-
Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer
-
Rajendran R, Garva R, Ashour H, et al. Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer. Int J Oncol, 2013, 42(6): 1961-1972.
-
(2013)
Int J Oncol
, vol.42
, Issue.6
, pp. 1961-1972
-
-
Rajendran, R.1
Garva, R.2
Ashour, H.3
-
17
-
-
84940360198
-
Advance in bioenergetic metabolic mechanisms of cancer cell
-
Hao LS, Zhang ZR, Wu XR. Advance in bioenergetic metabolic mechanisms of cancer cell. Zhongguo Pu Wai Ji Chu Yu Lin Chuang Za Zhi, 2010, 17(1): 97-101.
-
(2010)
Zhongguo Pu Wai Ji Chu Yu Lin Chuang Za Zhi
, vol.17
, Issue.1
, pp. 97-101
-
-
Hao, L.S.1
Zhang, Z.R.2
Wu, X.R.3
-
18
-
-
84863601677
-
Metformin reduces endogenous reactive oxygen species and associated DNA damage
-
Algire C, Moiseeva O, Deschenes-Simard X, et al. Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila), 2012, 5(4): 536-543.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, Issue.4
, pp. 536-543
-
-
Algire, C.1
Moiseeva, O.2
Deschenes-Simard, X.3
-
19
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy MP. How mitochondria produce reactive oxygen species. Biochem J, 2009, 417(1): 1-13.
-
(2009)
Biochem J
, vol.417
, Issue.1
, pp. 1-13
-
-
Murphy, M.P.1
-
20
-
-
82855182002
-
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue
-
Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, et al. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle, 2011, 10(23): 4047-4064.
-
(2011)
Cell Cycle
, vol.10
, Issue.23
, pp. 4047-4064
-
-
Whitaker-Menezes, D.1
Martinez-Outschoorn, U.E.2
Flomenberg, N.3
-
21
-
-
84881598688
-
Metformin enhances cisplatin cytotoxicity by suppressing Stat3 activity independently of the LKB1- AMPK pathway
-
Mar 22. [Epub ahead of print]
-
Lin CC, Yeh HH, Huang WL, et al. Metformin enhances cisplatin cytotoxicity by suppressing Stat3 activity independently of the LKB1- AMPK pathway. Am J Respir Cell Mol Biol, 2013 Mar 22. [Epub ahead of print]
-
(2013)
Am J Respir Cell Mol Biol
-
-
Lin, C.C.1
Yeh, H.H.2
Huang, W.L.3
-
22
-
-
84877928942
-
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumininduced epithelial-mesenchymal transition
-
Lee JH, Kim JH, Kim JS, et al. AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumininduced epithelial-mesenchymal transition. Am J Physiol Renal Physiol, 2013, 304(6): 686-697.
-
(2013)
Am J Physiol Renal Physiol
, vol.304
, Issue.6
, pp. 686-697
-
-
Lee, J.H.1
Kim, J.H.2
Kim, J.S.3
-
23
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature, 2012, 485(7400): 661-665.
-
(2012)
Nature
, vol.485
, Issue.7400
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
24
-
-
84868712140
-
In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma
-
Luo Q, Hu D, Hu S, et al. In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma. BMC Cancer, 2012, 12: 517.
-
(2012)
BMC Cancer
, vol.12
, pp. 517
-
-
Luo, Q.1
Hu, D.2
Hu, S.3
-
25
-
-
58149354390
-
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
-
Zhuang Y, Miskimins WK. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal, 2008, 3: 18.
-
(2008)
J Mol Signal
, vol.3
, pp. 18
-
-
Zhuang, Y.1
Miskimins, W.K.2
-
26
-
-
79960490420
-
Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells
-
Zhao L, Wen ZH, Jia CH, et al. Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells. Anat Rec (Hoboken), 2011, 294(8): 1337-1343.
-
(2011)
Anat Rec (Hoboken)
, vol.294
, Issue.8
, pp. 1337-1343
-
-
Zhao, L.1
Wen, Z.H.2
Jia, C.H.3
-
27
-
-
84874660234
-
Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: Population-based and in vitro studies
-
Chen HP, Shieh JJ, Chang CC, et al. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut, 2013, 62(4): 606-615.
-
(2013)
Gut
, vol.62
, Issue.4
, pp. 606-615
-
-
Chen, H.P.1
Shieh, J.J.2
Chang, C.C.3
-
28
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben SI, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene, 2008, 27(25): 3576-3586.
-
(2008)
Oncogene
, vol.27
, Issue.25
, pp. 3576-3586
-
-
Ben, S.I.1
Laurent, K.2
Loubat, A.3
-
29
-
-
84872529696
-
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
-
Hirsch HA, Iliopoulos D, Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. PNAS, 2013, 110(3): 972-977.
-
(2013)
PNAS
, vol.110
, Issue.3
, pp. 972-977
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Struhl, K.3
-
30
-
-
84867867477
-
The nuclear factor kappa B signaling pathway: Integrating metabolism with inf lammation
-
Tornatore L, Thotakura AK, Bennett J, et al. The nuclear factor kappa B signaling pathway: integrating metabolism with inf lammation. Trends Cell Biol, 2012, 22(11): 557-566.
-
(2012)
Trends Cell Biol
, vol.22
, Issue.11
, pp. 557-566
-
-
Tornatore, L.1
Thotakura, A.K.2
Bennett, J.3
-
31
-
-
0030600369
-
Optimal NF kappa B medi ated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals
-
Ginn-Pease ME, Whisler RL. Optimal NF kappa B medi ated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem Biophys Res Commun, 1996, 226(3): 695-702.
-
(1996)
Biochem Biophys Res Commun
, vol.226
, Issue.3
, pp. 695-702
-
-
Ginn-Pease, M.E.1
Whisler, R.L.2
-
32
-
-
10044224510
-
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazol idine-4 -carbox yl ic acid
-
Lee YC, Lee KS, Park SJ, et al. Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazol idine-4 -carbox yl ic acid. FASEB J, 2004, 18(15): 1917-1919.
-
(2004)
FASEB J
, vol.18
, Issue.15
, pp. 1917-1919
-
-
Lee, Y.C.1
Lee, K.S.2
Park, S.J.3
-
33
-
-
70350778443
-
An epigenetic switch involving NFkappaB, Lin28, Let-7 MicroRNA, and IL6 links inf lammation to cell transformation
-
Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NFkappaB, Lin28, Let-7 MicroRNA, and IL6 links inf lammation to cell transformation. Cell, 2009, 139(4): 693-706.
-
(2009)
Cell
, vol.139
, Issue.4
, pp. 693-706
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
34
-
-
84881580120
-
Research progress of solid tumor stem cells
-
Song EW. Research progress of solid tumor stem cells. Zhongshan Da Xue Xue Bao (Med Sci), 2010, 31(2): 172-178.
-
(2010)
Zhongshan Da Xue Xue Bao (Med Sci)
, vol.31
, Issue.2
, pp. 172-178
-
-
Song, E.W.1
-
35
-
-
79955834631
-
Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
-
Rattan R, Graham RP, Maguire JL, et al. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia, 2011, 13(5): 483-491.
-
(2011)
Neoplasia
, vol.13
, Issue.5
, pp. 483-491
-
-
Rattan, R.1
Graham, R.P.2
Maguire, J.L.3
-
36
-
-
84871742025
-
Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages
-
Ji G, Zhang Y, Yang Q, et al. Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages. PLoS One, 2012, 7(12): e53101.
-
(2012)
PLoS One
, vol.7
, Issue.12
-
-
Ji, G.1
Zhang, Y.2
Yang, Q.3
|