Hypoxia-inducible factor-1alpha: Molecular-targeted therapy for hepatocellular carcinoma

Mini-Reviews in Medicinal Chemistry

Volumn 13, Issue 9, 2013, Pages 1295-1304

  Dong, Z Z ^a   Yao, M ^a   Wang, L ^a   Wu, W ^a   Gu, X ^a   Yao, D F ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

And molecular targeted therapy; Angiopoietin 2; Hepatocellular carcinoma; Hypoxia inducible factor 1alpha; Vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN 2; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; VASCULOTROPIN;

ACUTE HEPATITIS; ANGIOGENESIS; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CHRONIC HEPATITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE SILENCING; HUMAN; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NECROSIS; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING;

CARCINOMA, HEPATOCELLULAR; GENE SILENCING; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MICRORNAS; MOLECULAR TARGETED THERAPY;

EID: 84881531075     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557511313090004     Document Type: Article

References (40)

1. Tang, Z. Y. Small hepatocellular carcinoma: current status and prospects. Hepatobiliary Pancreat Dis Int, 2002, 1, 349-53. [PMID: 14607706].
2. Raza, S. A.; Clifford, G. M.; Franceschi S. Worldwide variation in the relative importance of hepatitis B and hepatitic C viruses in hepatocellular carcinoma: a systematic review. Br. J. Cancer, 2007, 96, 1127-34. [PMID: 17406349].
3. Hui, K. M. Human hepatocellular carcinoma: Expression profilesbased molecular interpretations and clinical applications. Cancer Lett., 2009, 286, 96-102. [PMID: 19095350].
4. Feo, F.; Frau, M.; Tomasi, M. L.; Brozzetti, S.; Pascale, R. M. Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma. Exp. Biol. Med. (Maywood), 2009, 234, 726-36. [PMID: 19429855].
5. Liu, L.P.; Liang, H.F.; Chen, X.P.; Zhang, W.G.; Yang, S.L.; Xu, T.; Ren L. The role of NF-kappaB in Hepatitis b virus X proteinmediated upregulation of VEGF and MMPs. Cancer Invest., 2010, 28, 443-51. [PMID: 20073580].
6. Dong, Z. Z.; Yao, D. F.; Wu, W.; Yao, M.; Yu, H. B.; Shen, J. J.; Qiu, L. W.; Yao, N. H.; Sai, W. L.; Yang, J. L. Delayed hepatocarcinogenesis through antiangiogenic intervention in the nuclear factor-kappa B activation pathway in rats. Hepatobiliary Pancreat. Dis. Int., 2010, 9, 169-74.[PMID: 20382589].
7. Yao, D.F.; Dong, Z.Z.; Yao, M. Specific molecular markers in hepatocellular carcinoma. Hepatobiliary Pancreat. Dis. Int., 2007, 6, 241-7.[PMID: 17548245].
8. Xie, H.; Song, J.; Liu, K.; Ji, H.; Shen, H.; Hu, S.; Yang, G.; Du, Y.; Zou, X.; Jin, H.; Yan, L.; Liu, J.; Fan, D. The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein. Dig. Dis. Sci., 2008, 53, 3225-33[PMID: 18465238].
9. Daskalow, K.; Pfander, D.; Weichert, W.; Rohwer, N.; Thelen, A.; Neuhaus, P.; Jonas, S.; Wiedenmann, B.; Benckert, C.; Cramer, T. Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma. Histochem. Cell Biol., 2009, 132, 21-31[PMID: 19530262].
10. Mabjeesh, N. J.; Amir, S. Hypoxia-inducible factor (HIF) in human tumorigenesis. Histol. Histopathol., 2007, 22, 559-72.[PMID: 17330811].
11. Patiar, S.; Harris, A. L. Role of hypoxia-inducible factor-1alpha as a cancer therapy target. Endocr. Relat. Cancer, 2006, 13, S61-75.[PMID: 17259560].
12. Weidemann, A.; Johnson, R. S. Biology of HIF-1alpha. Cell Death Differ., 2008, 15, 621-7.[PMID: 18259201].
13. Liao, D.; Johnson, R. S. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev., 2007, 26, 281-90.[PMID: 17603752].
14. Copple, B. L.; Bustamante, J. J.; Welch, T. P.; Kim, N. D.; Moon, J. O. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int., 2009, 29, 1010-21[PMID: 19302442].
15. Semenza, G. L. Regulation of oxygen homeostasis by hypoxiainducible factor 1. Physiology (Bethesda), 2009, 24, 97-106[PMID: 19364912].
16. Brahimi-Horn, C.; Mazure, N.; Pouyssegur, J. Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal., 2005, 17, 1-9[PMID: 15451019].
17. Yao, D. F.; Jiang, H.; Yao, M.; Li, Y.; Gu, W. J.; Shen, Y. C.; Qiu, L. W.; Wu, W.; Wu, X.H.; Sai, W. L. Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma. Hepatobiliary Pancreat. Dis. Int., 2009, 8, 407-13[PMID: 19666411].
18. Wang, Y. L.; Yao, D. F.; Wu, W.; Sai, W. L.; Qiu, L. W.; Yang, J. L.; Zhu, J. W. Effect of siRNA-mediated inhibition of nuclear transcription factor-kappa B on apoptosis of hepatocarcinoma cells. Zhonghua Gan Zang Bing Za Zhi, 2010, 18, 609-13. Chinese.[PMID: 20825717].
19. Li, S.; Yao, D.; Wang, L.; Wu, W.; Qiu, L.; Yao, M.; Yao, N.; Zhang, H.; Yu, D.; Ni, Q. Expression characteristics of hypoxiainducible factor-1α and its clinical values in diagnosis and prognosis of hepatocellular carcinoma. Hepat Mon, 2011, 11, 821-8[PMID: 22224081].
20. Qian, J.; Yao, D.; Dong, Z.; Wu, W.; Qiu, L.; Yao, N.; Li, S.; Bian, Y.; Wang, Z.; Shi, G. Characteristics of hepatic igf-ii expression and monitored levels of circulating igf-ii mRNA in metastasis of hepatocellular carcinoma. Am. J. Clin. Pathol., 2010, 134, 799-806.[PMID: 20959664].
21. Xie, H.; Song, J.; Liu, K.; Ji, H.; Shen, H.; Hu, S.; Yang, G.; Du, Y.; Zou, X.; Jin, H.; Yan, L.; Liu, J.; Fan, D. The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein. Dig. Dis. Sci., 2008, 53, 3225-33.[PMID: 18465238].
22. Yoo, Y. G.; Na, T. Y.; Seo, H. W.; Seong, J. K.; Park, C. K.; Shin, Y. K.; Lee, M. O. Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene, 2008, 27, 3405-13.[PMID: 18264140].
23. Yao, D. F.; Qiu, L. W.; Wu, W.; Yao, N. H.; Li, S. S.; Bian, Y. Z. Dynamic alterations of VEGF and intervention of its expression on effect of hepatocyte malignant transformation. Zhonghua Yi Xue Za Zhi, 2010, 16, 3014-8. Chinese.[PMID: 21211317].
24. Ripoli, M.; D'Aprile, A.; Quarato, G.; Sarasin-Filipowicz, M.; Gouttenoire, J.; Scrima, R.; Cela, O.; Boffoli, D.; Heim, M. H.; Moradpour, D.; Capitanio, N.; Piccoli, C. Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1alpha-mediated glycolytic adaptation. J. Virol., 2010, 84, 647-60[PMID: 19846525].
25. Cummins, E. P.; Berra, E.; Comerford, K. M.; Ginouves, A.; Fitzgerald, K. T.; Seeballuck, F.Godson, C.; Nielsen, J. E.; Moynagh, P.; Pouyssegur, J.; Taylor, C. T. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc. Natl. Acad. Sci. USA, 2006, 103, 18154-9[PMID: 17114296].
26. Walmsley, S. R.; Print, C.; Farahi, N.; Peyssonnaux, C.; Johnson, R. S.; Cramer, T.; Sobolewski, A.; Condliffe, A. M.; Cowburn, A. S.; Johnson, N.; Chilvers, E. R. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J. Exp. Med., 2005, 201, 105-15[PMID: 15630139].
27. Buchler, P.; Reber, H. A.; Tomlinson, J. S.; Hankinson, O.; Kallifatidis, G.; Friess, H.; Herr, I.; Hines, O. J. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia, 2009, 11, 196-206[PMID: 19177204].
28. Kulshreshtha, R.; Davuluri, R. V.; Calin, G. A.; Ivan, M. A microRNA component of the hypoxic response. Cell Death Differ., 2008, 15, 667-71[PMID: 18219318].
29. Takahashi, Y.; Nishikawa, M.; Takakura, Y. Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes. Gene Ther., 2008, 15, 572-82.[PMID: 18273056].
30. Shin, D. H.; Li, S. H.; Yang, S. W.; Lee, B. L.; Lee, M. K.; Park, J. W. Inhibitor of nuclear factor-kappaB alpha derepresses hypoxiainducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. FEBS J., 2009, 276, 3470-80[PMID: 19456861].
31. van, Uden, P.; Kenneth, N. S.; Rocha, S. Regulation of hypoxiainducible factor-1alpha by NF-kappaB. Biochem. J., 2008, 412, 477-84[PMID: 18393939].
32. Dong, Z. Z.; Yao, D. F.; Li, S. S.; Yao, M.; Yu, D. D.; Yao, N. H.; Qian, Y. J.; Qiu, L. W. Inhibitory effect of miRNA silencing hypoxia-inducible factor alpha subunit gene on the proliferation of HepG2 cells. Zhonghua Gan Zang Bing Za Zhi, 2011, 19, 281-5. Chinese.[PMID: 21586227].
33. Hamaguchi, T.; Iizuka, N.; Tsunedomi, R.; Hamamoto, Y.; Miyamoto, T.; Iida, M.; Tokuhisa, Y.; Sakamoto, K.; Takashima, M.; Tamesa, T.; Oka, M. Glycolysis module activated by hypoxiainducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma. Int. J. Oncol., 2008, 33, 725-31[PMID: 18813785].
34. Forooghian, F.; Das, B. Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia-inducible factor-1alpha. Am. J. Ophthalmol., 2007, 144, 761-8[PMID: 17869204].
35. Nasimuzzaman, M.; Waris, G.; Mikolon, D.; Stupack, D. G.; Siddiqui, A. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J. Virol., 2007, 81, 10249-57[PMID: 17626077].
36. Lee, T. K.; Poon, R. T.; Yuen, A. P.; Ling, M. T.; Wang, X. H.; Wong, Y. C.; Guan, X. Y.; Man, K.; Tang, Z. Y.; Fan, S. T. Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor upregulation in hepatocellular carcinoma. Clin. Cancer Res., 2006, 12, 6910-9[PMID: 17145808].
37. Zhu, H.; Chen, X. P.; Luo, S. F.; Guan, J.; Zhang, W. G.; Zhang, B. X. Involvement of hypoxia-inducible factor-1alpha in multidrug resistance induced by hypoxia in HepG2 cells. J. Exp. Clin. Cancer Res., 2005, 24, 565-74[PMID: 16471319].
38. Wada, H.; Nagano, H. Yamamoto, H.; Yang, Y.; Kondo, M.; Ota, H.; Nakamura, M.; Yoshioka, S.; Kato, H.; Damdinsuren, B.; Tang, D.; Marubashi, S.; Miyamoto, A.; Takeda, Y.; Umeshita, K.; Nakamori, S.; Sakon, M.; Dono, K.; Wakasa, K.; Monden, M. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int., 2006, 26, 414-23[PMID: 16629644].
39. Yao, D. F.; Wu, X. H.; Zhu, Y.; Shi, G. S.; Dong, Z. Z.; Yao, D. B.; Wu, W.; Qiu, L. W.; Meng, X. Y. Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepato-cellular carcinoma. Hepatobiliary Pancreat. Dis. Int., 2005, 4, 220-6.[PMID: 15908319].
40. Jia, X.Q.; Cheng, H.Q.; Qian, X.; Bian, C.X.; Shi, Z.M.; Zhang, J.P.; Jiang, B.H.; Feng, Z.Q. Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma. Cell Biochem Biophys, 2012, 62, 237-44 [PMID: 21847633].