Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma

Hepatobiliary and Pancreatic Diseases International

Volumn 4, Issue 2, 2005, Pages 220-226

  Yao, Deng Fu ^a   Wu, Xin Hua ^a   Zhu, Yong ^a   Shi, Gong Sheng ^a   Dong, Zhi Zhen ^a   Yao, Deng Bing ^a   Wu, Wei ^a   Qiu, Li Wei ^a   Meng, Xian Yong ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

ELISA; Hepatocellular carcinoma; Immunohistochemistry; Microvascular density; Vascular endothelial growth factor

Indexed keywords

PEROXIDASE; RNA; STREPTAVIDIN; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION FUNCTION; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER RESECTION; MALE; METASTASIS; MICROVASCULATURE; PREDICTION; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; TUMOR RECURRENCE; TUMOR VASCULARIZATION; TUMOR VOLUME;

ADULT; AGED; ANGIOSTATINS; BIOPSY, NEEDLE; CAPILLARY PERMEABILITY; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RNA, NEOPLASM; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 20344371480     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Peto J. Cancer epidemiology in the last century and the next decade. Nature 2001;411:390-395.
2. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-346.
3. Tang ZY. Hepatocellular carcinoma-cause, treatment and metastasis. World J Gastroenterol 2001;7:445-454.
4. Yao DF, Jiang DR, Huang ZW, Lu JX, Tao QY, Yu ZJ, et al. Abnormal expression of hepatoma specific γ-glutamyl transferase and alteration of γ-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma. Cancer 2000; 88:761-769.
5. Akriviadis EA, Llovet JM, Efremidis SC, Shouval D, Canelo R, Ringes B, et al. Hepatocellular carcinoma. Br J Surg 1998; 85:1319-1331.
6. Orito E, Mizokami M. Hepatitis B virus genotypes and hepatocellular carcinoma in Japan. Intervirology 2003;46:408-412.
7. Edward T. Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus-associated hepatocellular carcinoma. J Med Virol 1994;42:357-376.
8. Jiang YF, Yang ZH, Hu JQ. Recurrence or metastasis of HCC: predictors, early detection and experimental antiangiogenic therapy. World J Gastroenterol 2000;6:61-65.
9. Toi M, Matsumoto T, Bando H. Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol 2001;2:667-673.
10. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
11. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 1999;77:527-543.
12. An FQ, Matsuda M, Fujii H, Matsumoto Y. Expression of vascular endothelial growth factor in surgical specimens of hepatocellular carcinoma. J Cancer Res Clin Oncol 2000;126:153-160.
13. Fang Y, Hu M, Liu K. Kinetics of tumorigenic vascular endothelial growth factor signalling and its significance in human hepatocellular carcinoma cells. Biomed Pharmacother 2001;55: 102-110.
14. von Marschall Z, Cramer T, Hocker M, Finkenzeller G, Wiedenmann B, Rosewicz S. Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut 2001;48:87-96.
15. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998;49:407-424.
16. Ng IO, Poon RT, Lee JM, Fan ST, Ng M, Tso WK. Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/EDR in hepatocellular carcinoma. Am J Clin Pathol 2001;116:838-845.
17. Poon RT, Ng IO, Lau C, Yu WC, Yang ZF, Fan ST, et al. Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J Clin Oncol 2002;20:1775-1785.
18. Torimura T, Sata M, Ueno T, Yin M, Tsuji R, Suzaku K, et al. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol 1998;29:986-991.
19. Nakashima O. Pathological diagnosis of hepatocellular carcinoma. Nippon Rinsho 2001;59:333-341.
20. Qin LX, Tang ZY. The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 2002;8:385-392.
21. Yen L, You XL, Al Moustafa AE, Batist G, Hynes NE, Mader S, et al. Heregulin selectively up-regulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 2000;19:3460-3469.
22. Carmeliet P. Angiogenesis in health and disease. Nature Med 2003;9:653-660.
23. Carmeliet P, Jain RK. Angiogenesis in cancer and other disease. Nature 2000;407:249-257.
24. Saaristo A, Karpanen T, Alitalo K. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis. Oncogene 2000;19:6122-6129.
25. Imura S, Miyake H, Izumi K, Tashiro S, Uehara H. Correlation of vascular endothelial cell proliferation with microvessel density and expression of vascular endothelial growth factor and basic fibroblast growth factor in hepatocellular carcinoma. J Med Invest 2004;51:202-209.
26. Yamaguchi R, Yano H, Nakashima Y, Ogasawara S, Higaki K, Akiba J, et al. Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. Oncol Rep 2000;7:725-729.
27. Chow NH, Hsu PI, Lin XZ, Yang HB, Chan SH, Cheng KS, et al. Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma: an immunohistochemical study. Hum Pathol 1997;28:698-703.
28. Li XM, Tang ZY, Zhou G, Lui YK, Ye SL. Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer Res 1998;17:13-17.
29. Chao Y, Li CP, Chau GY, Chen CP, King KL, Lui WY, et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol 2003;10:355-362.
30. Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998;28:68-77.
31. Saftoiu A, Ciurea T, Banita M, Georgescu C, Comanescu V, Rogoveanu I, et al. Immunohistochemical assessment of angiogenesis in primary hepatocellular carcinoma. Rom J Gastroenterol 2004;13:3-8.
32. Jeng KS, Sheen IS, Wang YC, Gu SL, Chu CM, Shih SC, et al. Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study. World J Gastroenterol 2004;10:643-648.
33. Xiong AP, Yang SR, Liang ZY, Xiao EH, Yu XP, Zhou SK, et al. Association between vascular endothelial growth factor and metastasis after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2004;3:386-390.
34. Qin LX, Tang ZY. Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature. J Cancer Res Clin Oncol 2004;130: 497-513.
35. Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res 2003;9:5339-5345.
36. Zhao ZC, Zheng SS, Wan YL, Jia CK, Xie HY. The molecular mechanism underlying angiogenesis in hepatocellular carcinoma: the imbalance activation of signaling pathways. Hepatobiliary Pancreat Dis Int 2003;2:529-536.
37. Ng IO, Guan XY, Poon RT, Fan ST, Lee JM. Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis. J Pathol 2003;199:345-353.
38. Cheng AS, Chan HL, To KF, Leung WX, Chan KK, Liew CT, et al. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. Int J Oncol 2004;24:853-860.
39. Sarbah SA, Gramlich T, Younoszai A, Osmack P, Goormastic M, Grosso L, et al. Risk factors for hepatocellular carcinoma in patients with cirrhosis. Dig Dis Sci 2004;49:850-853.
40. Jin-no K, Tanimizu M, Hyodo I, Nishikawa Y, Hosokawa Y, Doi T, et al. Circulating vascular endothelial growth factor (VEGF) is a possible tumor marker for metastasis in human hepatocellular carcinoma. J Gastroenterol 1998;33:376-382.
41. Akiyoshi F, Sata M, Suzaki H, Uchimura Y, Mitsuyama K, Matsuo K, et al. Serum vascular endothelial growth factor levels in various liver diseases. Dig Dis Sci 1998;43:41-45.
42. Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, et al. Concentration of vascular endothehal growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 1996;2:821-826.
43. Kraft A, Weindel K, Ochs A, Mardi C, Zmija J, Schumacher P, et al. Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer 1999;85:178-187.
44. Kim S, Park HS, Son HJ, Moon WS. The role of angiostatin, vascular endothelial growth factor, matrix metalloproteinase 9 and 12 in the angiogenesis of hepatocellular carcinoma. Korean J Hepatol 2004;10:62-72.
45. Yasuda S, Arii S, Mori A, Isobe N, Yang W, Oe H, et al. Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance. J Hepatol 2004;40:117-123.