Quantitative analysis of hepatic hypoxia-inducible factor-1α and its abnormal gene expression during the formation of hepatocellular carcinoma

Hepatobiliary and Pancreatic Diseases International

Volumn 8, Issue 4, 2009, Pages 407-413

  Yao, Deng Fu ^a   Jiang, Hua ^b   Yao, Min ^a   Li, Yue Ming ^a   Gu, Wen Jing ^a   Shen, Yu Cheng ^a   Qiu, Li Wei ^a   Wu, Wei ^a   Wu, Xin Hua ^a   Sai, Wen Li ^a  

^a NANTONG UNIVERSITY   (China)

^b Jiaonan People's Hospital   (China)

Author keywords

Dynamic alteration; Early expression; Hepatocellular carcinoma; Hypoxia inducible factor 1

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER MODEL; CANCER STAGING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGENERATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER HYPERPLASIA; MALE; MALIGNANT TRANSFORMATION; MORPHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

2-ACETYLAMINOFLUORENE; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; MOLECULAR SEQUENCE DATA; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 69249194933     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bosetti C, Levi F, Boffetta P, Lucchini F, Negri E, La Vecchia C. Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004. Hepatology 2008;48:137-145.
2. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-346. (Pubitemid 35154440)
3. Anzola M. Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J Viral Hepat 2004;11:383-393. (Pubitemid 39336219)
4. Dong ZZ, Yao DF, Yao DB, Wu XH, Wu W, Qiu LW, et al. Expression and alteration of insulin-like growth factor II-messenger RNA in hepatoma tissues and peripheral blood of patients with hepatocellular carcinoma. World J Gastroenterol 2005;11:4655-4660. (Pubitemid 41179518)
5. Ding L, Chen XP, Wang HP. Expression and clinical significance of HIF-1a protein in hepatocellular carcinoma tissues. Zhonghua Gan Zang Bing Za Zhi 2004;12:656-659.
6. Metzen E, Ratcliffe PJ. HIF hydroxylation and cellular oxygen sensing. Biol Chem 2004;385:223-230. (Pubitemid 38679067)
7. Dong ZZ, Yao DF, Yao M, Qiu LW, Zong L, Wu W, et al. Clinical impact of plasma TGF-beta1 and circulating TGF- betal mRNA in diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2008;7:288-295. (Pubitemid 351895389)
8. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47. (Pubitemid 37328806)
9. Han HK, Han CY, Cheon EP, Lee J, Kang KW. Role of hypoxia-inducible factor-alpha in hepatitis-B-virus X protein-mediated MDR1 activation. Biochem Biophys Res Commun 2007;357:567-573. (Pubitemid 46603168)
10. Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and hypoxia- inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol 2006;169:1251-1269. (Pubitemid 351194361)
11. Yoo YG, Cho S, Park S, Lee MO. The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha. FEBS Lett 2004;577:121-126. (Pubitemid 39452371)
12. Galanis A, Pappa A, Giannakakis A, Lanitis E, Dangaj D, Sandaltzopoulos R. Reactive oxygen species and HIF-1 signalling in cancer. Cancer Lett 2008;266:12-20.
13. Maxwell PH. The HIF pathway in cancer. Semin Cell Dev Biol 2005;16:523-530.
14. Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, et al. Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis. Cancer Res 2006;66:11263-11270. (Pubitemid 46009955)
15. Kaido T, Uemoto S. Recent evidence in the treatment of small hepatocellular carcinoma. Hepatogastroenterology 2008;55:1460-1462.
16. Wada H, Nagano H, Yamamoto H, Yang Y, Kondo M, Ota H, et al. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia- induced factor-1 alpha. Liver Int 2006;26:414-423.
17. Mabjeesh NJ, Amir S. Hypoxia-inducible factor (HIF) in human tumorigenesis. Histol Histopathol 2007;22:559-572. (Pubitemid 46647268)
18. Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 2006; 59:15-26.
19. Berra E, Ginouvès A, Pouysségur J. The hypoxia-inducible- factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep 2006;7:41-45.
20. Huang GW, Yang LY, Lu WQ. Expression of hypoxia- inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival. World J Gastroenterol 2005;11:1705-1708. (Pubitemid 40520818)
21. Jung SN, Yang WK, Kim J, Kim HS, Kim EJ, Yun H, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis 2008;29:713-721.
22. Alchera E, Tacchini L, Imarisio C, Dal Ponte C, De Ponti C, Gammella E, et al. Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells. Hepatology 2008;48:230-239. (Pubitemid 351975548)
23. Cho H, Lee HY, Ahn DR, Kim SY, Kim S, Lee KB, et al. Baicalein induces functional hypoxia-inducible factor- 1alpha and angiogenesis. Mol Pharmacol 2008;74:70-81. (Pubitemid 351872160)
24. Li Z, Lai Z, Ya K, Fang D, Ho YW, Lei Y, et al. Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J Cell Mol Med 2008;12:569-579. (Pubitemid 351555136)
25. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008;453:807-811. (Pubitemid 351793778)
26. Nakamura K, Zen Y, Sato Y, Kozaka K, Matsui O, Harada K, et al. Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver. Hum Pathol 2007;38:1532-1546. (Pubitemid 47418965)
27. Chan DW, Ng IO. Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells. J Pathol 2006;208:372-380. (Pubitemid 43210524)
28. Yoo YG, Na TY, Seo HW, Seong JK, Park CK, Shin YK, et al. Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 2008;27:3405-3413.
29. Ryu SH, Chung YH, Lee H, Kim JA, Shin HD, Min HJ, et al. Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma. Hepatology 2008; 47:929-936.
30. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-732.
31. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-466. (Pubitemid 39329586)
32. Lluis JM, Buricchi F, Chiarugi P, Morales A, Fernandez- Checa JC. Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor- {kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res 2007;67:7368-7377. (Pubitemid 47206567)
33. Takahashi Y, Nishikawa M, Takakura Y. Inhibition of tumor cell growth in the liver by RNA interference- mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes. Gene Ther 2008;15:572-582.
34. Seifert A, Katschinski DM, Tonack S, Fischer B, Navarrete Santos A. Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia- inducible factor-1 alpha signaling. Chem Res Toxicol 2008; 21:341-348.
35. WeiXing C, Tiantian H, Qun N, Chaohui Y, Ping X. Inhibitory effect of hypoxia inducible factor-1 antisense oligonucleotide on growth of human hepatocellular carcinoma cells. Med Oncol 2008;25:88-92.
36. Yao D, Jiang D, Huang Z, Lu J, Tao Q, Yu Z, et al. Abnormal expression of hepatoma specific gamma- glutamyl transferase and alteration of gamma-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma. Cancer 2000;88:761-769. (Pubitemid 30091094)