메뉴 건너뛰기




Volumn 286, Issue 1, 2009, Pages 96-102

Human hepatocellular carcinoma: Expression profiles-based molecular interpretations and clinical applications

Author keywords

Affymetrix microarrays; cDNA spotted DNA microarray; Differential gene expression profiling; HBV; HCV; Hepatocarcinogenesis; Hepatocellular carcinoma (HCC); HSV 1 amplicon vector; Iron homeostasis; Liver specific uncoupling protein; Prediction of recurrence; Suppression subtractive hybridization

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CARRIER PROTEIN; CAVEOLIN 2; CYCLIN A2; CYCLIN B1; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DNA; GELATINASE B; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HEPCIDIN; I KAPPA B; IRON; MACROPHAGE ELASTASE; MYC PROTEIN; N ACETYLGLUCOSAMINE 6 SULFATASE; NUCLEAR FACTOR Y; OSTEOPONTIN; PROTEIN C JUN; PROTEIN P53; PROTEIN SH3; RAS PROTEIN; RETINOBLASTOMA PROTEIN; RGS PROTEIN; STAT1 PROTEIN; STROMELYSIN 3; TRANSFORMING GROWTH FACTOR BETA1; UNINDEXED DRUG; VIRUS VECTOR; WNT PROTEIN;

EID: 70350569443     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.11.005     Document Type: Review
Times cited : (18)

References (46)
  • 1
    • 33749558598 scopus 로고    scopus 로고
    • Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa
    • Kirk G.D., Bah E., and Montesano R. Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa. Carcinogenesis 27 (2006) 2070-2082
    • (2006) Carcinogenesis , vol.27 , pp. 2070-2082
    • Kirk, G.D.1    Bah, E.2    Montesano, R.3
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., and DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 6 (2006) 674-687
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • Laurent-Puig P., and Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 25 (2006) 3778-3786
    • (2006) Oncogene , vol.25 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 4
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender L., Spector M.S., Xue W., Flemming P., Cordon-Cardo C., Silke J., et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125 (2006) 1253-1267
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1    Spector, M.S.2    Xue, W.3    Flemming, P.4    Cordon-Cardo, C.5    Silke, J.6
  • 5
    • 0033541491 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Schafer D.F., and Sorrell M.F. Hepatocellular carcinoma. Lancet 353 (1999) 1253-1257
    • (1999) Lancet , vol.353 , pp. 1253-1257
    • Schafer, D.F.1    Sorrell, M.F.2
  • 6
    • 18544365698 scopus 로고    scopus 로고
    • Gene-expression profiles predict survival of patients with lung adenocarcinoma
    • Beer D.G., Kardia S.L., Huang C.C., Giordano T.J., Levin A.M., Misek D.E., et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med. 8 (2002) 816-824
    • (2002) Nat. Med. , vol.8 , pp. 816-824
    • Beer, D.G.1    Kardia, S.L.2    Huang, C.C.3    Giordano, T.J.4    Levin, A.M.5    Misek, D.E.6
  • 7
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag H.B., and Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132 (2007) 2557-2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 9
    • 0037242696 scopus 로고    scopus 로고
    • Global control of primary hepatocellular carcinoma with hepatitis B vaccine: the contributions of research in Taiwan
    • Kane M.A. Global control of primary hepatocellular carcinoma with hepatitis B vaccine: the contributions of research in Taiwan. Cancer Epidemiol. Biomarkers Prev. 12 (2003) 2-3
    • (2003) Cancer Epidemiol. Biomarkers Prev. , vol.12 , pp. 2-3
    • Kane, M.A.1
  • 11
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh A.A., Eisen M.B., Davis R.E., Ma C., Lossos I.S., Rosenwald A., et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403 (2000) 503-511
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3    Ma, C.4    Lossos, I.S.5    Rosenwald, A.6
  • 12
    • 33846011470 scopus 로고    scopus 로고
    • A five-gene signature and clinical outcome in non-small-cell lung cancer
    • Chen H.Y., Yu S.L., Chen C.H., Chang G.C., Chen C.Y., Yuan A., et al. A five-gene signature and clinical outcome in non-small-cell lung cancer. N. Engl. J. Med. 356 (2007) 11-20
    • (2007) N. Engl. J. Med. , vol.356 , pp. 11-20
    • Chen, H.Y.1    Yu, S.L.2    Chen, C.H.3    Chang, G.C.4    Chen, C.Y.5    Yuan, A.6
  • 13
    • 35948981211 scopus 로고    scopus 로고
    • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma
    • Wang S., Ooi L., and Hui K.M. Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma. Clin. Cancer Res. 13 (2007) 6275-6283
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6275-6283
    • Wang, S.1    Ooi, L.2    Hui, K.M.3
  • 14
    • 33947540860 scopus 로고    scopus 로고
    • Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
    • Del Rio M., Molina F., Bascoul-Mollevi C., Copois V., Bibeau F., Chalbos P., et al. Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. J. Clin. Oncol. 25 (2007) 773-780
    • (2007) J. Clin. Oncol. , vol.25 , pp. 773-780
    • Del Rio, M.1    Molina, F.2    Bascoul-Mollevi, C.3    Copois, V.4    Bibeau, F.5    Chalbos, P.6
  • 15
    • 33646339959 scopus 로고    scopus 로고
    • Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer
    • Thuerigen O., Schneeweiss A., Toedt G., Warnat P., Hahn M., Kramer H., et al. Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer. J. Clin. Oncol. 20 (2006) 1839-1845
    • (2006) J. Clin. Oncol. , vol.20 , pp. 1839-1845
    • Thuerigen, O.1    Schneeweiss, A.2    Toedt, G.3    Warnat, P.4    Hahn, M.5    Kramer, H.6
  • 16
    • 34249692537 scopus 로고    scopus 로고
    • Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions
    • Bonavida B. Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions. Oncogene 26 (2007) 3629-3636
    • (2007) Oncogene , vol.26 , pp. 3629-3636
    • Bonavida, B.1
  • 17
    • 7244245510 scopus 로고    scopus 로고
    • Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein
    • Tan M., Ooi L.L., Aw S.E., and Hui K.M. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. J. Biol. Chem. 279 (2004) 45235-45244
    • (2004) J. Biol. Chem. , vol.279 , pp. 45235-45244
    • Tan, M.1    Ooi, L.L.2    Aw, S.E.3    Hui, K.M.4
  • 18
    • 46449095772 scopus 로고    scopus 로고
    • Identification of unique and common low abundance tumor-specific transcripts by suppression subtractive hybridization and oligonucleotide probe array analysis
    • Liu B.H., Goh C., Ooi L.L., and Hui K.M. Identification of unique and common low abundance tumor-specific transcripts by suppression subtractive hybridization and oligonucleotide probe array analysis. Oncogene 27 (2008) 4128-4136
    • (2008) Oncogene , vol.27 , pp. 4128-4136
    • Liu, B.H.1    Goh, C.2    Ooi, L.L.3    Hui, K.M.4
  • 19
    • 36749028203 scopus 로고    scopus 로고
    • Molecular pathways and related target therapies in liver carcinoma
    • Tommasi S., Pinto R., Pilato B., and Paradiso A. Molecular pathways and related target therapies in liver carcinoma. Curr. Pharm. Des. 13 (2007) 3279-3287
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 3279-3287
    • Tommasi, S.1    Pinto, R.2    Pilato, B.3    Paradiso, A.4
  • 20
    • 36749078065 scopus 로고    scopus 로고
    • The development of targeted therapies for hepatocellular cancer
    • Chattopadhyay D., Manas D.M., and Reeves H.L. The development of targeted therapies for hepatocellular cancer. Curr. Pharm. Des. 13 (2007) 3292-3300
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 3292-3300
    • Chattopadhyay, D.1    Manas, D.M.2    Reeves, H.L.3
  • 21
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kB and liver carcinogenesis
    • Arsura M., and Cavin L.G. Nuclear factor-kB and liver carcinogenesis. Cancer Lett. 229 (2005) 157-169
    • (2005) Cancer Lett. , vol.229 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 22
    • 33645318418 scopus 로고    scopus 로고
    • Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma
    • Gao Z.H., Tretiakova M.S., Liu W.H., Gong C., Farris P.D., and Hart J. Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma. Mod. Pathol. 19 (2006) 533-540
    • (2006) Mod. Pathol. , vol.19 , pp. 533-540
    • Gao, Z.H.1    Tretiakova, M.S.2    Liu, W.H.3    Gong, C.4    Farris, P.D.5    Hart, J.6
  • 23
    • 14744304730 scopus 로고    scopus 로고
    • Modulation of apoptosis as a target for liver disease
    • Eichhorst S.T. Modulation of apoptosis as a target for liver disease. Expert Opin. Ther. Targets 9 (2005) 83-99
    • (2005) Expert Opin. Ther. Targets , vol.9 , pp. 83-99
    • Eichhorst, S.T.1
  • 24
    • 34547874593 scopus 로고    scopus 로고
    • Current approaches in the transcriptional-guided gene therapy of human hepatocellular carcinoma
    • Hui K.M. Current approaches in the transcriptional-guided gene therapy of human hepatocellular carcinoma. Curr. Opin. Mol. Ther. 9 (2007) 378-384
    • (2007) Curr. Opin. Mol. Ther. , vol.9 , pp. 378-384
    • Hui, K.M.1
  • 26
    • 0034175969 scopus 로고    scopus 로고
    • Gene therapy: designer promoters for tumour targeting
    • Nettelbeck D.M., Jérôme V., and Müller R. Gene therapy: designer promoters for tumour targeting. Trends Genet. 16 (2000) 174-181
    • (2000) Trends Genet. , vol.16 , pp. 174-181
    • Nettelbeck, D.M.1    Jérôme, V.2    Müller, R.3
  • 27
  • 28
    • 34247265553 scopus 로고    scopus 로고
    • Engineering an improved cell cycle-regulatable herpes simplex virus type 1 amplicon vector with enhanced transgene expression in proliferating cells yet attenuated activities in resting cells
    • Wang G.Y., Ho I.A., Sia K.C., Miao L., Hui K.M., and Lam P.Y. Engineering an improved cell cycle-regulatable herpes simplex virus type 1 amplicon vector with enhanced transgene expression in proliferating cells yet attenuated activities in resting cells. Hum Gene Ther. 18 (2007) 222-231
    • (2007) Hum Gene Ther. , vol.18 , pp. 222-231
    • Wang, G.Y.1    Ho, I.A.2    Sia, K.C.3    Miao, L.4    Hui, K.M.5    Lam, P.Y.6
  • 29
    • 34249677913 scopus 로고    scopus 로고
    • An efficient and safe Herpes Simplex Virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas
    • Lam Y.P., Sia K.C., Khong J.K., Geest B.D., Lim K.S., Ho I.A., Wang G.Y., Miao L., Huynh H., and Hui K.M. An efficient and safe Herpes Simplex Virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas. Mol. Ther. 15 (2007) 1129-1136
    • (2007) Mol. Ther. , vol.15 , pp. 1129-1136
    • Lam, Y.P.1    Sia, K.C.2    Khong, J.K.3    Geest, B.D.4    Lim, K.S.5    Ho, I.A.6    Wang, G.Y.7    Miao, L.8    Huynh, H.9    Hui, K.M.10
  • 30
    • 0034964418 scopus 로고    scopus 로고
    • The two handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasions
    • Comijin J., Berx G., Vermassen P., Verschueren K., Grunsven L., Bruyneel E., et al. The two handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasions. Mol. Cell 7 (2001) 1267-1278
    • (2001) Mol. Cell , vol.7 , pp. 1267-1278
    • Comijin, J.1    Berx, G.2    Vermassen, P.3    Verschueren, K.4    Grunsven, L.5    Bruyneel, E.6
  • 31
    • 0032768089 scopus 로고    scopus 로고
    • Loss of heterozygosity and microsatellite instability in human non-neoplastic hepatic lesions
    • Tsopanomichalou M., Kouroumalis E., Ergazaki M., and Spandidos D.A. Loss of heterozygosity and microsatellite instability in human non-neoplastic hepatic lesions. Liver 19 (1999) 305-311
    • (1999) Liver , vol.19 , pp. 305-311
    • Tsopanomichalou, M.1    Kouroumalis, E.2    Ergazaki, M.3    Spandidos, D.A.4
  • 32
  • 33
    • 26944494627 scopus 로고    scopus 로고
    • 249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma
    • Kirk G.D., Lesi O.A., Mendy M., Szymanska K., Whittle H., Goedert J.J., et al. 249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma. Oncogene 24 (2005) 5858-5867
    • (2005) Oncogene , vol.24 , pp. 5858-5867
    • Kirk, G.D.1    Lesi, O.A.2    Mendy, M.3    Szymanska, K.4    Whittle, H.5    Goedert, J.J.6
  • 34
    • 0030846249 scopus 로고    scopus 로고
    • Prognostic significance of serum anti-p53 antibody in patients with hepatocellular carcinoma
    • Shiota G., Kishimoto Y., Suyama A., Okubo M., Katayama S., Harada K., et al. Prognostic significance of serum anti-p53 antibody in patients with hepatocellular carcinoma. J. Hepatol. 27 (1997) 661-668
    • (1997) J. Hepatol. , vol.27 , pp. 661-668
    • Shiota, G.1    Kishimoto, Y.2    Suyama, A.3    Okubo, M.4    Katayama, S.5    Harada, K.6
  • 35
    • 28444454447 scopus 로고    scopus 로고
    • Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis
    • Ramm G.A., and Ruddell R.G. Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin. Liver Dis. 25 (2005) 433-449
    • (2005) Semin. Liver Dis. , vol.25 , pp. 433-449
    • Ramm, G.A.1    Ruddell, R.G.2
  • 36
    • 7044222320 scopus 로고    scopus 로고
    • Iron, hemochromatosis, and hepatocellular carcinoma
    • Kowdley K.V. Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 127 (2004) S79-S86
    • (2004) Gastroenterology , vol.127
    • Kowdley, K.V.1
  • 38
    • 70350569555 scopus 로고    scopus 로고
    • Uncoupling proteins-how do they work and how are they regulated
    • Klingenberg M. Uncoupling proteins-how do they work and how are they regulated. IUBMB Life 32 (2000) 89-90
    • (2000) IUBMB Life , vol.32 , pp. 89-90
    • Klingenberg, M.1
  • 39
    • 0034669375 scopus 로고    scopus 로고
    • Restriction of energy intake, energy expenditure, and aging
    • Ramsey J.J., Harper M.E., and Weindruch R. Restriction of energy intake, energy expenditure, and aging. Free Radic. Biol. Med. 29 (2000) 946-968
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 946-968
    • Ramsey, J.J.1    Harper, M.E.2    Weindruch, R.3
  • 40
    • 0013851005 scopus 로고
    • Evidence discriminating between the chemical and the chemiosmotic mechanisms of electron transport phosphorylation
    • Mitchell P., and Moyle J. Evidence discriminating between the chemical and the chemiosmotic mechanisms of electron transport phosphorylation. Nature 208 (1965) 1205-1206
    • (1965) Nature , vol.208 , pp. 1205-1206
    • Mitchell, P.1    Moyle, J.2
  • 42
    • 0035797118 scopus 로고    scopus 로고
    • Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
    • Modica-Napolitano J.S., and Aprille J.R. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv. Drug Deliv. Rev. 49 (2001) 63-70
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 63-70
    • Modica-Napolitano, J.S.1    Aprille, J.R.2
  • 43
    • 0035797106 scopus 로고    scopus 로고
    • Mitochondria-based photodynamic anti-cancer therapy
    • Morgan J., and Oseroff A.R. Mitochondria-based photodynamic anti-cancer therapy. Adv. Drug Deliv. Rev. 49 (2001) 71-86
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 71-86
    • Morgan, J.1    Oseroff, A.R.2
  • 44
    • 32944480899 scopus 로고    scopus 로고
    • Opportunities for targeted therapies in hepatocellular carcinoma
    • Thomas M.B., and Abbruzzese J.L. Opportunities for targeted therapies in hepatocellular carcinoma. J. Clin. Oncol. 23 (2005) 8093-8108
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8093-8108
    • Thomas, M.B.1    Abbruzzese, J.L.2
  • 45
    • 35648950024 scopus 로고    scopus 로고
    • Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets
    • Katoh H., Ojima H., Kokubu A., Saito S., Kondo T., Kosuge T., et al. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. Gastroenterology 133 (2007) 1475-1486
    • (2007) Gastroenterology , vol.133 , pp. 1475-1486
    • Katoh, H.1    Ojima, H.2    Kokubu, A.3    Saito, S.4    Kondo, T.5    Kosuge, T.6
  • 46
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S., Rickman D.S., de Reyniès A., Balabaud C., Rebouissou S., Jeannot E., et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 45 (2007) 42-52
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reyniès, A.3    Balabaud, C.4    Rebouissou, S.5    Jeannot, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.