Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys

BMC Neuroscience

Volumn 14, Issue , 2013, Pages

  Kocerha, Jannet ^a,b,d   Liu, Yuhong ^a   Willoughby, David ^c   Chidamparam, Kumaravel ^c   Benito, Joseph ^c   Nelson, Kate ^a   Xu, Yan ^a,b   Chi, Tim ^a   Engelhardt, Heidi ^a   Moran, Sean ^a   Yang, Shang Hsun ^a   Li, Shi Hua ^b   Li, Xiao Jiang ^b   Larkin, Katherine ^a   Neumann, Adam ^a   Banta, Heather ^a   Yang, Jin Jing ^a   Chan, Anthony W S ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Ocean Ridge Biosciences   (United States)

^d GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

Blood; Huntington's disease; Longitudinal; Monkeys; mRNA; Transcriptome

Indexed keywords

HUNTINGTIN; POLYGLUTAMINE; HTT PROTEIN, HUMAN; MESSENGER RNA; NERVE PROTEIN; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUNTINGTON CHOREA; LONGITUDINAL STUDY; NONHUMAN; RHESUS MONKEY; TRANSCRIPTOMICS; TRANSGENIC ANIMAL; ANIMAL; BLOOD; DISEASE COURSE; DISEASE MODEL; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; METABOLISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; HUNTINGTON DISEASE; LONGITUDINAL STUDIES; MACACA MULATTA; MALE; NERVE TISSUE PROTEINS; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84881517260     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-14-88     Document Type: Article

References (41)

1. Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol 1997, 42(4):604-612. 10.1002/ana.410420411, 9382472.
2. Vassos E, Panas M, Kladi A, Vassilopoulos D. Higher levels of extroverted hostility detected in gene carriers at risk for Huntington's disease. Biol Psychiatry 2007, 62(12):1347-1352. 10.1016/j.biopsych.2006.12.016, 17610848.
3. Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayan J, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci USA 2004, 101(10):3498-3503. 373491, 14993615.
4. Yoon G, Kramer J, Zanko A, Guzijan M, Lin S, Foster-Barber A, Boxer AL. Speech and language delay are early manifestations of juvenile-onset Huntington disease. Neurology 2006, 67(7):1265-1267. 10.1212/01.wnl.0000238390.86304.4e, 17030763.
5. Zizak VS, Filoteo JV, Possin KL, Lucas JA, Rilling LM, Davis JD, Peavy G, Wong A, Salmon DP. The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction. Cogn Behav Neurol 2005, 18(4):198-205. 10.1097/01.wnn.0000192134.53616.39, 16340392.
6. Berrios GE, Wagle AC, Markova IS, Wagle SA, Ho LW, Rubinsztein DC, Whittaker J, Ffrench-Constant C, Kershaw A, Rosser A, et al. Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Res 2001, 102(3):217-225. 10.1016/S0165-1781(01)00257-8, 11440772.
7. Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum Genet 1982, 34(3):481-488. 1685335, 6211092.
8. Roos RA, Hermans J, Vegter-Van Der Vlis M, Van Ommen GJ, Bruyn GW. Duration of illness in Huntington's disease is not related to age at onset. J Neurol Neurosurg Psychiatry 1993, 56(1):98-100. 10.1136/jnnp.56.1.98, 1014774, 8429330.
9. Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, et al. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc Natl Acad Sci USA 2005, 102(31):11023-11028. 10.1073/pnas.0504921102, 1182457, 16043692.
10. Cha JH. Transcriptional signatures in Huntington's disease. Prog Neurobiol 2007, 83(4):228-248. 10.1016/j.pneurobio.2007.03.004, 2449822, 17467140.
11. Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, et al. Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet 2006, 15(6):965-977. 10.1093/hmg/ddl013, 16467349.
12. Sipione S, Rigamonti D, Valenza M, Zuccato C, Conti L, Pritchard J, Kooperberg C, Olson JM, Cattaneo E. Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses. Hum Mol Genet 2002, 11(17):1953-1965. 10.1093/hmg/11.17.1953, 12165557.
13. Runne H, Kuhn A, Wild EJ, Pratyaksha W, Kristiansen M, Isaacs JD, Regulier E, Delorenzi M, Tabrizi SJ, Luthi-Carter R. Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood. Proc Natl Acad Sci USA 2007, 104(36):14424-14429. 10.1073/pnas.0703652104, 1964868, 17724341.
14. Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, et al. Towards a transgenic model of Huntington's disease in a non-human primate. Nature 2008, 453(7197):921-924. 10.1038/nature06975, 2652570, 18488016.
15. Crook ZR, Housman D. Huntington's disease: can mice lead the way to treatment?. Neuron 2011, 69(3):423-435. 10.1016/j.neuron.2010.12.035, 21315254.
16. Johnson CD, Davidson BL. Huntington's disease: progress toward effective disease-modifying treatments and a cure. Hum Mol Genet 2010, 19(R1):R98-R102. 10.1093/hmg/ddq148, 2875055, 20421366.
17. Ross CA. Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron 2002, 35(5):819-822. 10.1016/S0896-6273(02)00872-3, 12372277.
18. Ross CA, Tabrizi SJ. Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 2011, 10(1):83-98. 10.1016/S1474-4422(10)70245-3, 21163446.
19. Kennedy L, Shelbourne PF. Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?. Hum Mol Genet 2000, 9(17):2539-2544. 10.1093/hmg/9.17.2539, 11030759.
20. Mangiarini L, Sathasivam K, Mahal A, Mott R, Seller M, Bates GP. Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. Nat Genet 1997, 15(2):197-200. 10.1038/ng0297-197, 9020849.
21. Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron 2009, 64(6):828-840. 10.1016/j.neuron.2009.11.020, 2807408, 20064390.
22. Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA. Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiol Dis 2006, 21(2):392-403. 10.1016/j.nbd.2005.08.001, 16165367.
23. Group HS. Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996, 11(2):136-142.
24. Ferreira IL, Cunha-Oliveira T, Nascimento MV, Ribeiro M, Proenca MT, Januario C, Oliveira CR, Rego AC. Bioenergetic dysfunction in Huntington's disease human cybrids. Exp Neurol 2011, 231(1):127-134. 10.1016/j.expneurol.2011.05.024, 21684277.
25. Josefsen K, Nielsen SM, Campos A, Seifert T, Hasholt L, Nielsen JE, Norremolle A, Skotte NH, Secher NH, Quistorff B. Reduced gluconeogenesis and lactate clearance in Huntington's disease. Neurobiol Dis 2010, 40(3):656-662. 10.1016/j.nbd.2010.08.009, 20727971.
26. Tasset I, Sanchez-Lopez F, Aguera E, Fernandez-Bolanos R, Sanchez FM, Cruz-Guerrero A, Gascon-Luna F, Tunez I. NGF and nitrosative stress in patients with Huntington's disease. J Neurol Sci 2012, 315(1-2):133-136.
27. Van Roon-Mom WM, Pepers BA, Hoen PA T, Verwijmeren CA, Den Dunnen JT, Dorsman JC, Van Ommen GB. Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease. BMC Mol Biol 2008, 9:84. 10.1186/1471-2199-9-84, 2588454, 18844975.
28. Weir DW, Sturrock A, Leavitt BR. Development of biomarkers for Huntington's disease. Lancet Neurol 2011, 10(6):573-590. 10.1016/S1474-4422(11)70070-9, 21601164.
29. Chan AW, Kocerha J. The path to microRNA therapeutics in psychiatric and neurodegenerative disorders. Front Genet 2012, 3:82. 3354561, 22629284.
30. Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ. Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Hum Mol Genet 2010, 19(20):3919-3935. 10.1093/hmg/ddq306, 2947400, 20660112.
31. Liang Y, Jansen M, Aronow B, Geiger H, Van Zant G. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet 2007, 39(2):178-188. 10.1038/ng1938, 17220891.
32. Mitsunaga K, Kikuchi J, Wada T, Furukawa Y. Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells. J Cell Physiol 2012, 227(3):1138-1147. 10.1002/jcp.22834, 21567403.
33. Muthusamy V, Premi S, Soper C, Platt J, Bosenberg M. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. J Invest Dermatol 2013, 133(7):1827-1833. 10.1038/jid.2013.48, 23364479.
34. Bjorkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med 2008, 205(8):1869-1877. 10.1084/jem.20080178, 2525598, 18625748.
35. Kwan W, Trager U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, et al. Mutant huntingtin impairs immune cell migration in Huntington disease. J Clin Invest 2012, 122(12):4737-4747. 10.1172/JCI64484, 3533551, 23160193.
36. Sanchez-Lopez F, Tasset I, Aguera E, Feijoo M, Fernandez-Bolanos R, Sanchez FM, Ruiz MC, Cruz AH, Gascon F, Tunez I. Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease. Neurol Res 2012, 34(7):721-724. 10.1179/1743132812Y.0000000073, 22889672.
37. Dupont P, Besson MT, Devaux J, Lievens JC. Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila. Neurobiol Dis 2012, 47(2):237-247. 10.1016/j.nbd.2012.04.007, 22531500.
38. Kalathur RK, Hernandez-Prieto MA, Futschik ME. Huntington's disease and its therapeutic target genes: a global functional profile based on the HD research crossroads database. BMC Neurol 2012, 12:47. 10.1186/1471-2377-12-47, 3492045, 22741533.
39. Lewandowski NM, Bordelon Y, Brickman AM, Angulo S, Khan U, Muraskin J, Griffith EY, Wasserman P, Menalled L, Vonsattel JP, et al. Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease. Neurobiol Dis 2013, 52:84-93.
40. Silva AC, Almeida S, Laco M, Duarte AI, Domingues J, Oliveira CR, Januario C, Rego AC. Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers. Mitochondrion 2013, S1567-7249(13):00080-00089.
41. Putkhao K, Kocerha J, Cho IK, Yang J, Parnpai R, Chan AW. Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's Disease. Stem Cells Dev 2013, 22(8):1198-1205. 10.1089/scd.2012.0469, 23190281.