Oxidative stress and inflammation biomarkers in the blood of patients with huntington's disease

Neurological Research

Volumn 34, Issue 7, 2012, Pages 721-724

  Sánchez López, Fernando ^a   Tasset, Inmaculada ^b   Agüera, Eduardo ^a   Feijóo, Montserrat ^b   Fernández Bolaños, Ricardo ^c   Sánchez, Francisco M ^c   Ruiz, María C ^b   Cruz, Antonio H ^d   Lix Gascón, Fé ^d   Túnez, Isaac ^b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Universidad de Cordoba   (Spain)

^c HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^d Maimonides Institute for Research in Biomedicine of Cordoba   (Spain)

Author keywords

Biomarkers; Huntington disease; Immune system; Oxidative stress

Indexed keywords

3 NITROTYROSINE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; NITRITE; THIOREDOXIN 1; THIOREDOXIN REDUCTASE 1;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; ERYTHROCYTE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; INFLAMMATION; LEUKOCYTE; LEUKOCYTE COUNT; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RISK FACTOR; SENSITIVITY AND SPECIFICITY;

ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; HUNTINGTON DISEASE; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; OXIDATIVE STRESS;

EID: 84865112006     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000073     Document Type: Article

References (22)

1. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr. Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol. 1985;44: 559-77.
2. Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med. 2008;205:1869-77.
3. Wild E, Björkqvist M, Tabrizi SJ. Immune markers for Huntington's disease? Expert Rev Neurother. 2008;8:1779-81.
4. Leblhuber F, Walli J, Jellinger K, Tilz GP, Widner B, Laccone F, et al. Activated immune system in patients with Hungtinton's disease. Clin Chem Lab Med. 1988;36:747-50.
5. Andrich JE, Wobben M, Klotz P, Goetze O, Saft C. Upper gastrointestinal findings in Huntington's disease: patients suffer but do not complain. J Neural Transm. 2009;116:1607-11.
6. Mancuso MF, Coppede L, Migliore L, Siciliano G, Murri L. Mitochondrial dysfunction, oxidative stress and neurodegeneration. J Alzheimers Dis. 2006;10:59-73.
7. Klepac N, Relja M, Klepac R, Hecimovic S, Babic T, Trkulja V. Oxidative stress parameters in plasma of Huntington's disease gene carriers and healthy subjects. J Neurol. 2007;254:1676-83.
8. De Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, et al. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med. 2008;45:1375-83.
9. Boll MC, Alcaraz-Zubeldia M, Montes S, Rios C8. Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NOx content in the CSF. A different marker profile in four neurodegenerative diseases. Neurochem Res. 2008;33:1717-23.
10. Sorolla MA, Reverter-Branchat G, Tamarit J, Ferrer I, Ros J, Cabiscol E. Proteomic and oxidative stress analysis in human brain samples of Huntington disease. Free Radic Biol Med. 2008;45:667-78.
11. Tasset I, Sánchez F, Túnez I. The molecular bases of Huntington's disease: the role played by oxidative stress. Rev Neurol. 2009;49:424-9.
12. Túnez I, Sánchez-López F, Agüera E, Fernández-Bolaños R, Sánchez FM, Tasset-Cuevas I. Important role of oxidative stress biomarkers in Huntington's disease. J Med Chem. 2011;54:5602-6.
13. Galasko D, Montine TJ. Biomarkers of oxidative damage and inflammation in Alzheimer's disease. Biomark Med. 2010;4: 27-36.
14. Miller RL, James-Kracke M, Sun GY, Sun AY. Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res. 2009;34:55-65.
15. Agostinho P, Cunha RA, Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des. 2010;16:2766-78.
16. Huntington Study Group. Unified Huntington's disease rating scale: reliability and consistency. Mov Disor. 1996;11:136-42.
17. Folstein MS, Folstein SE, McHugh PR. 'Mini Mental State' a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-98.
18. Ricart-Jané D, Llobera M, López-Tejero MD. Anticoagulants and other preanalytical factors interfere in plasma nitrate/nitrite quantification by the Griess method. Nitric Oxid. 2002;6:178-85.
19. Hsiao HY, Chern Y. Targeting glial cells to elucidate the pathogenesis of Huntington's disease. Mol Neurobiol. 2010;41:248-55.
20. Lee YJ, Han SB, Nam SY, Oh KW, Hong JT. Inflammation and Alzheimer's disease. Arch Pharm Res. 2010;33:1539-56.
21. Galimberti D, Scarpini E. Inflammation and oxidative damage in Alzheimer's disease: friend or foe? Front Biosci. 2011;3:252-66.
22. Heilman JM, Burke TJ, McClain CJ, Watson WH. Transactivation of gene expression by NFkb is dependent on thioredoxin reductase activity. Free Radic Biol Med. 2011;51:1533-42.