메뉴 건너뛰기




Volumn 47, Issue 2, 2012, Pages 237-247

Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila

Author keywords

Bang sensitivity; Giant escape fibers; Huntington's disease; Neuron glia interaction

Indexed keywords

AXIN; BETA CATENIN; HUNTINGTIN; TRANSCRIPTION FACTOR; WNT1 PROTEIN;

EID: 84861655279     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.04.007     Document Type: Article
Times cited : (39)

References (43)
  • 2
    • 0036276050 scopus 로고    scopus 로고
    • Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease
    • Alvarez G., Munoz-Montano J.R., Satrustegui J., Avila J., Bogonez E., Diaz-Nido J. Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. Bipolar Disord. 2002, 4:153-165.
    • (2002) Bipolar Disord. , vol.4 , pp. 153-165
    • Alvarez, G.1    Munoz-Montano, J.R.2    Satrustegui, J.3    Avila, J.4    Bogonez, E.5    Diaz-Nido, J.6
  • 3
    • 40249094509 scopus 로고    scopus 로고
    • Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling
    • Ataman B., Ashley J., Gorczyca M., Ramachandran P., Fouquet W., Sigrist S.J., Budnik V. Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling. Neuron 2008, 57:705-718.
    • (2008) Neuron , vol.57 , pp. 705-718
    • Ataman, B.1    Ashley, J.2    Gorczyca, M.3    Ramachandran, P.4    Fouquet, W.5    Sigrist, S.J.6    Budnik, V.7
  • 6
    • 33845367423 scopus 로고    scopus 로고
    • Flying at the head of the pack: Wnt biology in Drosophila
    • Bejsovec A. Flying at the head of the pack: Wnt biology in Drosophila. Oncogene 2006, 25:7442-7449.
    • (2006) Oncogene , vol.25 , pp. 7442-7449
    • Bejsovec, A.1
  • 7
    • 0036741645 scopus 로고    scopus 로고
    • Targeted increase in shaggy activity levels blocks wingless signaling
    • Bourouis M. Targeted increase in shaggy activity levels blocks wingless signaling. Genesis 2002, 34:99-102.
    • (2002) Genesis , vol.34 , pp. 99-102
    • Bourouis, M.1
  • 8
    • 76049118058 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
    • Bradford J., Shin J.Y., Roberts M., Wang C.E., Li X.J., Li S. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:22480-22485.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 22480-22485
    • Bradford, J.1    Shin, J.Y.2    Roberts, M.3    Wang, C.E.4    Li, X.J.5    Li, S.6
  • 9
    • 33947675275 scopus 로고    scopus 로고
    • Oxidative damage in Huntington's disease pathogenesis
    • Browne S.E., Beal M.F. Oxidative damage in Huntington's disease pathogenesis. Antioxid. Redox Signal. 2006, 8:2061-2073.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 2061-2073
    • Browne, S.E.1    Beal, M.F.2
  • 10
    • 0037072807 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
    • Carmichael J., Sugars K.L., Bao Y.P., Rubinsztein D.C. Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J. Biol. Chem. 2002, 277:33791-33798.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33791-33798
    • Carmichael, J.1    Sugars, K.L.2    Bao, Y.P.3    Rubinsztein, D.C.4
  • 14
    • 33744958556 scopus 로고    scopus 로고
    • Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
    • Chen J., Park C.S., Tang S.J. Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J. Biol. Chem. 2006, 281:11910-11916.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11910-11916
    • Chen, J.1    Park, C.S.2    Tang, S.J.3
  • 16
    • 69049091946 scopus 로고    scopus 로고
    • Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease
    • Cummings D.M., Andre V.M., Uzgil B.O., Gee S.M., Fisher Y.E., Cepeda C., Levine M.S. Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease. J. Neurosci. 2009, 29:10371-10386.
    • (2009) J. Neurosci. , vol.29 , pp. 10371-10386
    • Cummings, D.M.1    Andre, V.M.2    Uzgil, B.O.3    Gee, S.M.4    Fisher, Y.E.5    Cepeda, C.6    Levine, M.S.7
  • 18
    • 0041856097 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways
    • Espinosa L., Ingles-Esteve J., Aguilera C., Bigas A. Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J. Biol. Chem. 2003, 278:32227-32235.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32227-32235
    • Espinosa, L.1    Ingles-Esteve, J.2    Aguilera, C.3    Bigas, A.4
  • 19
    • 34249108600 scopus 로고    scopus 로고
    • Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
    • Farias G.G., Valles A.S., Colombres M., Godoy J.A., Toledo E.M., Lukas R.J., Barrantes F.J., Inestrosa N.C. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J. Neurosci. 2007, 27:5313-5325.
    • (2007) J. Neurosci. , vol.27 , pp. 5313-5325
    • Farias, G.G.1    Valles, A.S.2    Colombres, M.3    Godoy, J.A.4    Toledo, E.M.5    Lukas, R.J.6    Barrantes, F.J.7    Inestrosa, N.C.8
  • 20
    • 33746384132 scopus 로고    scopus 로고
    • Metabolic disruption in Drosophila bang-sensitive seizure mutants
    • Fergestad T., Bostwick B., Ganetzky B. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Genetics 2006, 173:1357-1364.
    • (2006) Genetics , vol.173 , pp. 1357-1364
    • Fergestad, T.1    Bostwick, B.2    Ganetzky, B.3
  • 21
    • 0346749473 scopus 로고    scopus 로고
    • Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-d-aspartate receptor activation in Huntington's disease knock-in striatal cells
    • Gines S., Ivanova E., Seong I.S., Saura C.A., MacDonald M.E. Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-d-aspartate receptor activation in Huntington's disease knock-in striatal cells. J. Biol. Chem. 2003, 278:50514-50522.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50514-50522
    • Gines, S.1    Ivanova, E.2    Seong, I.S.3    Saura, C.A.4    MacDonald, M.E.5
  • 22
    • 77954886545 scopus 로고    scopus 로고
    • Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease
    • Godin J.D., Poizat G., Hickey M.A., Maschat F., Humbert S. Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J. 2010, 29:2433-2445.
    • (2010) EMBO J. , vol.29 , pp. 2433-2445
    • Godin, J.D.1    Poizat, G.2    Hickey, M.A.3    Maschat, F.4    Humbert, S.5
  • 24
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson G.R., Wiedau-Pazos M., Sang T.K., Wagle N., Brown C.A., Massachi S., Geschwind D.H. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 2002, 34:509-519.
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 25
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J., Amanai K., Wang G., Tang J., Wang B., Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 2002, 416:548-552.
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 28
    • 0033981645 scopus 로고    scopus 로고
    • Modifications of seizure susceptibility in Drosophila
    • Kuebler D., Tanouye M.A. Modifications of seizure susceptibility in Drosophila. J. Neurophysiol. 2000, 83:998-1009.
    • (2000) J. Neurophysiol. , vol.83 , pp. 998-1009
    • Kuebler, D.1    Tanouye, M.A.2
  • 29
    • 40549084657 scopus 로고    scopus 로고
    • AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease
    • Liévens J.C., Iche M., Laval M., Faivre-Sarrailh C., Birman S. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Hum. Mol. Genet. 2008, 17:882-894.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 882-894
    • Liévens, J.C.1    Iche, M.2    Laval, M.3    Faivre-Sarrailh, C.4    Birman, S.5
  • 30
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 31
    • 0032554841 scopus 로고    scopus 로고
    • Roles of Armadillo, a Drosophila catenin, during central nervous system development
    • Loureiro J., Peifer M. Roles of Armadillo, a Drosophila catenin, during central nervous system development. Curr. Biol. 1998, 8:622-632.
    • (1998) Curr. Biol. , vol.8 , pp. 622-632
    • Loureiro, J.1    Peifer, M.2
  • 33
    • 33745919542 scopus 로고    scopus 로고
    • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila
    • McCartney B.M., Price M.H., Webb R.L., Hayden M.A., Holot L.M., Zhou M., Bejsovec A., Peifer M. Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 2006, 133:2407-2418.
    • (2006) Development , vol.133 , pp. 2407-2418
    • McCartney, B.M.1    Price, M.H.2    Webb, R.L.3    Hayden, M.A.4    Holot, L.M.5    Zhou, M.6    Bejsovec, A.7    Peifer, M.8
  • 34
    • 70350638920 scopus 로고    scopus 로고
    • Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells
    • Mezhybovska M., Yudina Y., Abhyankar A., Sjolander A. Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. Br. J. Cancer 2009, 101:1596-1605.
    • (2009) Br. J. Cancer , vol.101 , pp. 1596-1605
    • Mezhybovska, M.1    Yudina, Y.2    Abhyankar, A.3    Sjolander, A.4
  • 35
    • 0027418602 scopus 로고
    • Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
    • Ruel L., Bourouis M., Heitzler P., Pantesco V., Simpson P. Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch. Nature 1993, 362:557-560.
    • (1993) Nature , vol.362 , pp. 557-560
    • Ruel, L.1    Bourouis, M.2    Heitzler, P.3    Pantesco, V.4    Simpson, P.5
  • 38
    • 48749133346 scopus 로고    scopus 로고
    • Wnt signaling in neuroprotection and stem cell differentiation
    • Toledo E.M., Colombres M., Inestrosa N.C. Wnt signaling in neuroprotection and stem cell differentiation. Prog. Neurobiol. 2008, 86:281-296.
    • (2008) Prog. Neurobiol. , vol.86 , pp. 281-296
    • Toledo, E.M.1    Colombres, M.2    Inestrosa, N.C.3
  • 39
    • 3543111486 scopus 로고    scopus 로고
    • Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants
    • Trotta N., Rodesch C.K., Fergestad T., Broadie K. Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. J. Neurobiol. 2004, 60:328-347.
    • (2004) J. Neurobiol. , vol.60 , pp. 328-347
    • Trotta, N.1    Rodesch, C.K.2    Fergestad, T.3    Broadie, K.4
  • 40
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker F.O. Huntington's disease. Lancet 2007, 369:218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 41
    • 49649117786 scopus 로고    scopus 로고
    • Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
    • Wang C.E., Tydlacka S., Orr A.L., Yang S.H., Graham R.K., Hayden M.R., Li S., Chan A.W., Li X.J. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum. Mol. Genet. 2008, 17:2738-2751.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2738-2751
    • Wang, C.E.1    Tydlacka, S.2    Orr, A.L.3    Yang, S.H.4    Graham, R.K.5    Hayden, M.R.6    Li, S.7    Chan, A.W.8    Li, X.J.9
  • 42
    • 0032841989 scopus 로고    scopus 로고
    • A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
    • Willert K., Logan C.Y., Arora A., Fish M., Nusse R. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development 1999, 126:4165-4173.
    • (1999) Development , vol.126 , pp. 4165-4173
    • Willert, K.1    Logan, C.Y.2    Arora, A.3    Fish, M.4    Nusse, R.5
  • 43
    • 77954851049 scopus 로고    scopus 로고
    • Wnt signaling regulates mitochondrial physiology and insulin sensitivity
    • Yoon J.C., Ng A., Kim B.H., Bianco A., Xavier R.J., Elledge S.J. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010, 24:1507-1518.
    • (2010) Genes Dev. , vol.24 , pp. 1507-1518
    • Yoon, J.C.1    Ng, A.2    Kim, B.H.3    Bianco, A.4    Xavier, R.J.5    Elledge, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.