Compartment-specific control of signaling from a DNA-sensing immune receptor

Science Signaling

Volumn 3, Issue 150, 2010, Pages

  Engel, Alex ^a   Barton, Gregory M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLATHRIN; CYTOKINE; DNA; INTERFERON; INTERLEUKIN 12P40; TOLL LIKE RECEPTOR 9; BACTERIAL DNA; DNA BINDING PROTEIN; ENHANCER BINDING PROTEIN AP 3; ENHANCER-BINDING PROTEIN AP-3; IL12B PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; VIRUS DNA;

BACTERIUM; CELL COMMUNICATION; CELL MIGRATION; DNA VIRUS; GENE INDUCTION; HOST RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; GENETIC TRANSCRIPTION; HUMAN; IMMUNOLOGY; METABOLISM;

DNA VIRUSES;

ANIMALS; DNA, BACTERIAL; DNA, VIRAL; DNA-BINDING PROTEINS; HUMANS; INTERFERON TYPE I; INTERLEUKIN-12 SUBUNIT P40; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 78649825344     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3150pe45     Document Type: Review

References (26)

1. M. W. Boulé, C. Broughton, F. Mackay, S. Akira, A. Marshak-Rothstein, I. R. Rifkin, Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199, 1631-1640 (2004).
2. J. Lund, A. Sato, S. Akira, R. Medzhitov, A. Iwasaki, Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520 (2003).
3. M. Sasai, M. M. Linehan, A. Iwasaki, Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science 329, 1530-1534 (2010).
4. G. M. Barton, J. C. Kagan, R. Medzhitov, Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7, 49-56 (2006).
5. S. E. Ewald, B. L. Lee, L. Lau, K. E. Wickliffe, G. P. Shi, H. A. Chapman, G. M. Barton, The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456, 658-662 (2008).
6. B. Park, M. M. Brinkmann, E. Spooner, C. C. Lee, Y. M. Kim, H. L. Ploegh, Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat. Immunol. 9, 1407-1414 (2008).
7. F. E. Sepulveda, S. Maschalidi, R. Colisson, L. Heslop, C. Ghirelli, E. Sakka, A. M. Lennon- Duménil, S. Amigorena, L. Cabanie, B. Manoury, Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 31, 737-748 (2009).
8. E. Latz, A. Verma, A. Visintin, M. Gong, C. M. Sirois, D. C. Klein, B. G. Monks, C. J. McKnight, M. S. Lamphier, W. P. Duprex, T. Espevik, D. T. Golenbock, Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat. Immunol. 8, 772-779 (2007).
9. H. Häcker, V. Redecke, B. Blagoev, I. Kratchmarova, L. C. Hsu, G. G. Wang, M. P. Kamps, E. Raz, H. Wagner, G. Häcker, M. Mann, M. Karin, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439, 204-207 (2006).
10. K. Hoshino, T. Sugiyama, M. Matsumoto, T. Tanaka, M. Saito, H. Hemmi, O. Ohara, S. Akira, T. Kaisho, IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature 440, 949-953 (2006).
11. G. Oganesyan, S. K. Saha, B. Guo, J. Q. He, A. Shahangian, B. Zarnegar, A. Perry, G. Cheng, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439, 208-211 (2006).
12. M. L. Shinohara, L. Lu, J. Bu, M. B. Werneck, K. S. Kobayashi, L. H. Glimcher, H. Cantor, Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells. Nat. Immunol. 7, 498-506 (2006).
13. S. Uematsu, S. Sato, M. Yamamoto, T. Hirotani, H. Kato, F. Takeshita, M. Matsuda, C. Coban, K. J. Ishii, T. Kawai, O. Takeuchi, S. Akira, Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201, 915-923 (2005).
14. K. Honda, Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, T. Taniguchi, Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434, 1035-1040 (2005).
15. C. Guiducci, G. Ott, J. H. Chan, E. Damon, C. Calacsan, T. Matray, K. D. Lee, R. L. Coffman, F. J. Barrat, Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203, 1999-2008 (2006).
16. R. Lande, J. Gregorio, V. Facchinetti, B. Chatterjee, Y. H. Wang, B. Homey, W. Cao, Y. H. Wang, B. Su, F. O. Nestle, T. Zal, I. Mellman, J. M. Schröder, Y. J. Liu, M. Gilliet, Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564-569 (2007).
17. K. Okuya, Y. Tamura, K. Saito, G. Kutomi, T. Torigoe, K. Hirata, N. Sato, Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome. J. Immunol. 184, 7092-7099 (2010).
18. K. Gotoh, Y. Tanaka, A. Nishikimi, R. Nakamura, H. Yamada, N. Maeda, T. Ishikawa, K. Hoshino, T. Uruno, Q. Cao, S. Higashi, Y. Kawaguchi, M. Enjoji, R. Takayanagi, T. Kaisho, Y. Yoshikai, Y. Fukui, Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. J. Exp. Med. 207, 721-730 (2010).
19. J. S. Bonifacino, L. M. Traub, Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72, 395-447 (2003).
20. A. A. Peden, V. Oorschot, B. A. Hesser, C. D. Austin, R. H. Scheller, J. Klumperman, Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J. Cell Biol. 164, 1065-1076 (2004).
21. A. L. Blasius, C. N. Arnold, P. Georgel, S. Rutschmann, Y. Xia, P. Lin, C. Ross, X. Li, N. G. Smart, B. Beutler, Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1014051107 (2010).
22. Y. M. Kim, M. M. Brinkmann, M. E. Paquet, H. L. Ploegh, UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452, 234-238 (2008).
23. W. Wong, J. D. Scott, AKAP signalling complexes: Focal points in space and time. Nat. Rev. Mol. Cell Biol. 5, 959-970 (2004).
24. J. C. Kagan, T. Su, T. Horng, A. Chow, S. Akira, R. Medzhitov, TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β. Nat. Immunol. 9, 361-368 (2008).
25. R. Barbalat, L. Lau, R. M. Locksley, G. M. Barton, Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat. Immunol. 10, 1200-1207 (2009).
26. H. Yanai, D. Savitsky, T. Tamura, T. Taniguchi, Regulation of the cytosolic DNA-sensing system in innate immunity: A current view. Curr. Opin. Immunol. 21, 17-22 (2009).