Wnt signaling is altered by spinal cord neuronal dysfunction in amyotrophic lateral sclerosis transgenic mice

Neurochemical Research

Volumn 38, Issue 9, 2013, Pages 1904-1913

  Yu, Li ^a   Guan, Yingjun ^a   Wu, Xin ^a   Chen, Yanchun ^a   Liu, Zhijun ^a   Du, Hongmei ^a   Wang, Xin ^b  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Amyotrophic lateral sclerosis; PCR array; Spinal cord; Transgenic mice; Wnt

Indexed keywords

CASEIN KINASE IALPHA; CASEIN KINASE IALPHA1; CYCLIN D1; CYCLIN D2; CYCLIN D3; E1A ASSOCIATED P300 PROTEIN; FOS LIKE ANTIGEN 1; GLIAL FIBRILLARY ACIDIC PROTEIN; NEMO LIKE KINASE; PROTEIN FOS; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR PITX3; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT PROTEIN; WNT1 PROTEIN; WNT10A PROTEIN; WNT16 PROTEIN; WNT2 PROTEIN; WNT3 PROTEIN; WNT3A PROTEIN; WNT4 PROTEIN; WNT7A PROTEIN; WNT7B PROTEIN; WNT8A PROTEIN; WNT9A PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GRAY MATTER; GROWTH REGULATION; IMMUNOFLUORESCENCE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPINAL CORD; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING; WHITE MATTER; WILD TYPE; WNT SIGNALING PATHWAY;

MUS; MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; GENE EXPRESSION PROFILING; MICE; MICE, TRANSGENIC; NEURONS; SIGNAL TRANSDUCTION; SPINAL CORD; WNT PROTEINS;

EID: 84881481374     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1096-y     Document Type: Article

References (36)

1. Tripathi VB, Al-Chalabi A (2008) Molecular insights and therapeutic targets in amyotrophic lateral sclerosis. CNS Neurol Disord: Drug Targets 7:11-19
2. Kiernan MC, Vucic S, Cheah BC et al (2011) Amyotrophic lateral sclerosis. Lancet 377:942-955
3. Usuki S, Kamitani T, Matsuo Y et al (2012) Pathobiochemical effect of acylated steryl-beta-glucoside on aggregation and cytotoxicity of alpha-synuclein. Neurochem Res 37:1261-1266
4. Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 7:710-723
5. Kuzma-Kozakiewicz M, Kwiecinski H (2011) New therapeutic targets for amyotrophic lateral sclerosis. Expert Opin Ther Targets 15:127-143
6. Gama Sosa MA, De Gasperi RElder GA (2011) Modeling human neurodegenerative diseases in transgenic systems. Hum Genet 131:535-563
7. Guan YJ, Wang X, Wang HY et al (2007) Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. J Neurochem 102:1125-1138
8. Gordon MD, Nusse R (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429-22433
9. Boonen RA, van Tijn PZivkovic D (2009) Wnt signaling in Alzheimer's disease: up or down, that is the question. Ageing Res Rev 8:71-82
10. Inestrosa NC, Arenas E (2010) Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci 11:77-86
11. Godin JD, Poizat G, Hickey MA et al (2010) Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J 29:2433-2445
12. Wang Y (2009) Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy. Mol Cancer Ther 8:2103-2109
13. Rao TP, Kuhl M (2010) An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 106:1798-1806
14. Chen Y, Guan Y, Liu H et al (2012) Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice. Biochem Biophys Res Commun 420:397-403
15. Clevers H, Nusse R (2012) Wnt/beta-Catenin Signaling and Disease. Cell 149:1192-1205
16. L'Episcopo F, Serapide MF, Tirolo C et al (2011) A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener 6:49
17. Chen H, Guo Y, Hu M et al (2010) Differential expression and alternative splicing of genes in lumbar spinal cord of an amyotrophic lateral sclerosis mouse model. Brain Res 1340:52-69
18. Kudo LC, Parfenova L, Vi N et al (2010) Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Hum Mol Genet 19:3233-3253
19. Kaur P, Mani S, Cros MP et al (2012) Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma. Tumour Biol 33:325-336
20. Munji RN, Choe Y, Li G et al (2011) Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci 31:1676-1687
21. Mao CD, Byers SW (2011) Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr 21:207-236
22. Katoh M (2011) Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells. Curr Pharm Biotechnol 12:160-170
23. Di Giovanni S, Movsesyan V, Ahmed F et al (2005) Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci USA 102:8333-8338
24. Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53:387-397
25. Ota S, Ishitani S, Shimizu N et al (2012) NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J 31:1904-1915
26. Enjin A, Rabe N, Nakanishi ST et al (2010) Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells. J Comp Neurol 518:2284-2304
27. Katoh M (2008) WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets 9:565-570
28. Kleber M, Sommer L (2004) Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol 16:681-687
29. KM H (2011) Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS ONE 6:e19279
30. Lasiene J, Yamanaka K (2011) Glial cells in amyotrophic lateral sclerosis. Neurol Res Int 2011:718987
31. Lie DC, Colamarino SA, Song HJ et al (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437:1370-1375
32. Bovolenta P, Esteve P, Ruiz JM et al (2008) Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121:737-746
33. Buechling T, Boutros M (2011) Wnt signaling at and above the receptor level. Curr Top Dev Biol 97:21-53
34. Hsieh JC, Kodjabachian L, Rebbert ML et al (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398:431-436
35. Hu YA, Gu X, Liu J et al (2008) Expression pattern of Wnt inhibitor factor 1(Wif1) during the development in mouse CNS. Gene Expr Patterns 8:515-522
36. Chi L, Ke Y, Luo C et al (2006) Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. Stem Cells 24:34-43