Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c] quinoline derivatives

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7653-7663

  Tseng, Chih Hua ^a   Tzeng, Cherng Chyi ^a   Chung, Kuin Yu ^a   Kao, Chai Lin ^a   Hsu, Chih Yao ^a   Cheng, Chih Mei ^a   Huang, Keng Shiang ^b   Chen, Yeh Long ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

Author keywords

6 Arylindeno 1,2 c quinoline derivatives; Antiproliferative activity; Apoptotic induction

Indexed keywords

2 FLUORO 9 HYDROXY 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 2 FLUORO 9 HYDROXY 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE OXIME; 2 FLUORO 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PIPERIDIN 1 YL)ETHYL OXIME; 2 FLUORO 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 2 FLUORO 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 2 FLUORO 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE OXIME; 2,9 DIMETHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 2,9 DIMETHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE OXIME; 2,9 DIMETHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLINE 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 6 (4 HYDROXYPHENYL) 9 [2 (PYRROLIDIN 1 YL)ETHOXY] 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 6 [4 [3 (DIMETHYLAMINO)PROPOXY]PHENYL] 2 FLUORO 9 HYDROXY 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 6 [4 [3 (DIMETHYLAMINO)PROPOXY]PHENYL] 2 FLUORO 9 HYDROXY 1H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 6 [4 [3 (DIMETHYLAMINO)PROPOXY]PHENYL] 9 HYDROXY 1H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 9 [3 (DIMETHYLAMINO)PROPOXY] 2 FLUORO 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 9 [3 (DIMETHYLAMINO)PROPOXY] 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 9 HYDROXY 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 9 HYDROXY 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 9 HYDROXY 6 (4 HYDROXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE OXIME; 9 HYDROXY 6[4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL] 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PIPERIDIN 1 YL)ETHYL OXIME; 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 2 (PYRROLIDIN 1 YL)ETHYL OXIME; 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLIN 11 ONE 3 (DIMETHYLAMINO)PROPYL OXIME; 9 METHOXY 6 (4 METHOXYPHENYL) 11H INDENO[1,2 C]QUINOLINE 11 ONE OXIME; CASPASE 8; IRINOTECAN; PROTEIN BAX; PROTEIN P53; QUINOLINE DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; TIME;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE; HUMANS; NEOPLASMS; QUINOLINES;

EID: 82255179858     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.014     Document Type: Article

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