Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6259-6264

  Kemnitzer, William ^a   Kuemmerle, Jared ^a   Jiang, Songchun ^a   Zhang, Han Zhong ^a   Sirisoma, Nilantha ^a   Kasibhatla, Shailaja ^a   Crogan Grundy, Candace ^a   Tseng, Ben ^a   Drewe, John ^a   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

Author keywords

Anticancer agents; Apoptosis inducer; HTS

Indexed keywords

1 [4 (1H IMIDAZOL 1 YL)BENZOYL] 3 CYANOPYRROLO[1,2 A]QUINOLINE; 1 BENZOYL 3 CYANOPYRROLO[1,2 A]QUINOLINE; 1 BENZOYL 3 CYANOPYRROLO[1,2 A]QUINOLINE DERIVATIVE; CASPASE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN HCT116; DRUG MECHANISM; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HCT116 CELLS; HUMANS; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 55549140112     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.110     Document Type: Article

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