Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6402-6405

  Alhamadsheh, Mamoun M ^a   Waters, Norman C ^b   Sachdeva, Sarbjot ^a   Lee, Patricia ^b   Reynolds, Kevin A ^a  

^a PORTLAND STATE UNIVERSITY   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

FabH; Fatty acid biosynthesis; Inhibition; Plasmodium falciparum; SAR

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ENZYME INHIBITOR; SULFONYLNAPHTHALENE 1,4 DIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GROWTH INHIBITION; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANIMALS; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESCHERICHIA COLI; FATTY ACIDS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MUTATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM;

EID: 56249125949     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.097     Document Type: Article

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