The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa

Microbes and Infection

Volumn 2, Issue 14, 2000, Pages 1721-1731

  Rumbaugh, Kendra P ^a   Griswold, John A ^a   Hamood, Abdul N ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Pathogenesis; Pseudomonas aeruginosa; Quorum sensing

Indexed keywords

VIRULENCE FACTOR;

BACTERIAL VIRULENCE; BIOFILM; CELL DENSITY; DEVICE; HOST RESISTANCE; IMMUNE RESPONSE; IN VIVO STUDY; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0033638927     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)01327-7     Document Type: Review

References (67)

1. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
2. Quorum-sensing cross talk: Isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria
3. Influence of Pseudomonas aeruginosa exoproducts on virulence factor production in Burkholderia cepacia: Evidence of interspecies communication
4. Bacterial tactic responses
5. Current topics in signal transduction in bacteria
6. Recent advances in biology: Intercellular communication and quorum sensing in micro-organisms
7. Thinking about bacterial populations as multicellular organisms
8. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
9. Intercellular communication and group behavior in bacteria
10. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
11. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
12. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
13. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
14. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa
15. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa
16. A general role for the lux auto-inducer in bacterial cell signaling: Control of antibiotic biosynthesis in Erwinia
17. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes
18. Pseudomonas aeruginosa LasA: A second elastase under the transcriptional control of lasR
19. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
20. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression
21. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
22. Effect of rpoS mutation on the stress response and expression of virulence factors in Pseudomonas aeruginosa
23. Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: lasR/lasI Mutants exhibit reduced pyoverdine biosynthesis
24. Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa
25. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase
26. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS
27. Roles of Pseudomonas aeruginora las and rhl quorum-sensing systems in control of twitching motility
28. In vivo studies disprove an obligatory role of azurin in denitrification in Pseudomonas aeruginosa and show that azu expression is under control of rpoS and ANR
29. Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide
30. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
31. Vfr controls quorum sensing in Pseudomonas aeruginosa
32. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
33. The chain of command in Pseudomonas quorum sensing
34. Quinolone signaling in the cell-to-cell communcation system of Pseudomonas aeruginosa
35. Regulation of quorum sensing by RpoS in Pseudomonas aeruginosa
36. How bacteria talk to each other: Regulation of gene expression by quorum sensing
37. Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria
38. Self perception in bacteria: Quorum sensing with acylated homoserine lactones
39. Cell-to-cell signaling and Pseudomonas aeruginosa infections
40. Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators
41. The bacterial 'enigma': Cracking the code of cell-cell communication
42. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection
43. Diverse Preudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8
44. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections
45. ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury
46. Pseudomonas aeruginosa cell-to-cell signalling is required for virulence in a model of acute pulmonary infection
47. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB and toxA in chronic lung infections associated with cystic fibrosis
48. Contribution of proteases and LasR to the virulence of Pseudomohas aeruginosa during corneal infections
49. Pseudomonas aeruginosa outbreak in a burn unit: Role of antimicrobials in the emergence of multiply resistant strains
50. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections
51. Contribution of the regulatory gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice
52. Common virulence factors for bacterial pathogenicity in plants and animals
53. Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis
54. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model
55. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors
56. Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa
57. Bacterial biofilms: A common cause of persistent infections
58. The involvement of cell-to-cell signals in the development of a bacterial biofilm
59. Evidence of autoinducer activity in naturally occurring biofilms
60. Biofilms on indwelling urethral catheters produce quorum-sensing signal molecules in situ and in vitro
61. Quorum sensing: A novel target for antiinfective therapy
62. Quorum sensing: Potential means of treating Gram-negative infections?
63. Novel synthetic analogs of the Pseudomonas autoinducer
64. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity
65. Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells