Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5407-5413

  Gros, Guillaume ^a   Martinez, Lorena ^b   Gimenez, Anna Servat ^a   Adler, Paula ^a,d   Maurin, Philippe ^a   Wolkowicz, Roland ^c   Falson, Pierre ^b   Hasserodt, Jens ^a  

^a Laboratoire de Chimie Organique   (France)

^b UNIVERSITÉ LYON 1   (France)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Antiviral agents; Cellular assay; Chemical synthesis; Cyclic urea; HIV 1 protease inhibitors; Quaternary hemiaminal; Transition state isostere

Indexed keywords

1 BENZYL 3 [1 (4 HYDROXY)BENZYL 2 OXO ETHYL] 1 PIPERIDIN 1 YL UREA; BREAST CANCER RESISTANCE PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; HYBRID PROTEIN; MULTIDRUG RESISTANCE PROTEIN; SAQUINAVIR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN FOLDING; T LYMPHOCYTE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIVIRAL AGENTS; CELLULAR ASSAY; CHEMICAL SYNTHESIS; CYCLIC UREA; HIV-1 PROTEASE INHIBITORS; QUATERNARY HEMIAMINAL; TRANSITION-STATE ISOSTERE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CELL SURVIVAL; HEK293 CELLS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MICE; NEOPLASM PROTEINS; NIH 3T3 CELLS; P-GLYCOPROTEIN; UREA;

EID: 84881375418     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.018     Document Type: Article

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