Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4875-4885

  Dragovich, Peter S ^a   Bair, Kenneth W ^b   Baumeister, Timm ^b   Ho, Yen Ching ^b   Liederer, Bianca M ^a   Liu, Xiongcai ^c   Liu, Yongbo ^c   O'Brien, Thomas ^a   Oeh, Jason ^a   Sampath, Deepak ^a   Skelton, Nicholas ^a   Wang, Leslie ^a   Wang, Weiru ^a   Wu, Hongxing ^c   Xiao, Yang ^a   Yuen, Po Wai ^c   Zak, Mark ^a   Zhang, Lei ^c   Zheng, Xiaozhang ^b  

^a GENENTECH INC   (United States)

^b Forma Therapeutics   (United States)

^c Pharmaron Beijing Co Ltd   (China)

Author keywords

Aqueous solubility; NAMPT; Nicotinamide phosphoribosyltransferase; Tumor metabolism; X ray crystal structure

Indexed keywords

NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PYRROLO[3,4 C]PYRIDINE DERIVATIVE; UREA;

ARTICLE; CRYSTAL STRUCTURE; HUMAN; IC 50; IN VITRO STUDY; NONHUMAN; PROTEIN DETERMINATION; XENOGRAFT;

AQUEOUS SOLUBILITY; NAMPT; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; TUMOR METABOLISM; X-RAY CRYSTAL STRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOKINES; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; NEOPLASMS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84881371744     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.090     Document Type: Article

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