Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1153-1164

  You, Hyun ^a   Youn, Hyung Seop ^a   Im, Isak ^a   Bae, Man Ho ^a   Lee, Sang Kook ^b   Ko, Hyojin ^a   Eom, Soo Hyun ^a   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

FK866; Nicotinamide adenine dinucleotide (NAD +); Nicotinamide phosphoribosyltransferase (NAmPRTase); Pre B cell colony enhancing factor (PBEF); X ray crystal structure

Indexed keywords

3 (1H PYRAZOL 4 YL)ACRYLIC ACID; 3 (2 AMINOPHENYL) N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL]ACRYLAMIDE; 3 (2 AMINOPYRIMIDIN 5 YL) N [4 (1 BENZOYLPIPERIDINE 4 YL)BUTYL]ACRYLAMIDE; 3 (2 AMINOPYRIMIDIN 5 YL)ACRYLIC ACID; 3 (3 AMINOPHENYL) N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL]ACRYLAMIDE; 3 (PYRIMIDIN 5 YL)ACRYLIC ACID; 4 BROMP 1 TOSYL 1H PYRAZOLE; [4 (4 AMINOBUTYL)PIPERIDIN 1 YL](PHENYL)METHANONE; ANTINEOPLASTIC AGENT; ASPARTIC ACID; DAPORINAD; METHYL 4 (1 BENZOYLPIPERIDIN 4 YL)BUTANOTE; N [4 (1 BENZOYL 4 PIPERIDINYL)BUTYL] 3 (3 PYRIDINYL)ACRYLAMIDE DERIVATIVE; N [4 (1 BENZOYLPIPERIDIN 3 YL)BUTYL] 3 (1H PYRAZOL 4 YL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 3 YL)BUTYL] 3 (PYRIMIDIN 5 YL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 3 YL)BUTYL] 4 (1H INDOL 3 YL)BUT 2 ENAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 (1 METHYL 1H PYRROL 2 YL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 (1H IMIDAZOL 4 YL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 (1H PYRROL 2 YL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 (2 NITROPHENYL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 (3 NITROPHENYL)ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 [1 [4 HYDROXY 3 (HYDROXYMETHYL)BUTYL] 1H IMIDAZOL 4 YL]ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 [1 [4 HYDROXY 3 (HYDROXYMETHYL)BUTYL] 1H INDOL 3 YL]ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 [1 [4 HYDROXY 3 (HYDROXYMETHYL)BUTYL] 1H PYRAZOL 4 YL]ACRYLAMIDE; N [4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL] 3 [1 [4 HYDROXY 3 (HYDROXYMETHYL)BUTYL] 1H PYRROL 2 YL]ACRYLAMIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR; NITROGEN; PYRROLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; X RAY CRYSTALLOGRAPHY;

ACRYLAMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; PROTEIN CONFORMATION; RIBOSE;

EID: 79952281704     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.034     Document Type: Article

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