Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3 H -quinazolin-6-yl)methylprop-2- ynylamino]- N -(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt)

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8734-8746

  Lockman, Jeffrey W ^a   Murphy, Brett R ^a   Zigar, Daniel F ^a   Judd, Weston R ^a   Slattum, Paul M ^a   Gao, Zhong Hua ^a   Ostanin, Kirill ^a   Green, Jeremy ^a   McKinnon, Rena ^a   Terry Lorenzo, Ryan T ^a   Fleischer, Tracey C ^a   Boniface, J Jay ^a   Shenderovich, Mark ^a   Willardsen, J Adam ^a  

^a Myrexis Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 BENZOTRIAZIN 4 ONE DERIVATIVE; 3 PYRIDYLMETHYLAMIDE DERIVATIVE; 3,3 DIMETHYLALLYL DERIVATIVE; 4 [(7 BROMO 2 METHYL 4 OXO 3H QUINAZOLIN 6 YL)METHYLPROP 2 YNYLAMINO] N (3 PYRIDYLMETHYL)BENZAMIDE; 4 [N (7 BROMO 3,4 DIHYDRO 2 METHYL 4 OXO 6 QUINAZOLINYLMETHYL) N (2 PROPYNYL)AMINO] N (3 PYRIDYLMETHYL)BENZAMIDE; BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; QUINAZOLIN 4 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZAMIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MODELS, MOLECULAR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650348764     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101145b     Document Type: Article

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