Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4471-4475

  Jiang, Yongwei ^a   Zhang, Jun ^a   Cao, Yongbing ^a   Chai, Xiaoyun ^a   Zou, Yan ^a   Wu, Qiuye ^a   Zhang, Dazhi ^a   Jiang, Yuanying ^a   Sun, Qingyan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activity; CYP51; Molecular docking; Synthesis; Triazole

Indexed keywords

1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL) 1H 1,2,4 TRIAZOL 5(4H)ONE DERIVATIVE; AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CONTROLLED STUDY; DRUG BINDING; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; KLUYVEROMYCES MARXIANUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

14-ALPHA DEMETHYLASE INHIBITORS; ANTIFUNGAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; STEROL 14-DEMETHYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

CANDIDA ALBICANS; FUNGI;

EID: 79960346297     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.008     Document Type: Article

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