Geldanamycin inhibits TGF-β signaling through induction of Hsp70

Archives of Biochemistry and Biophysics

Volumn 495, Issue 1, 2010, Pages 8-13

  Yun, Chang Hyun ^a   Yoon, Sun Young ^a   Nguyen, Thuy Trang ^a   Cho, Han Yang ^a   Kim, Tae Hyun ^a   Kim, Shin Tae ^a   Kim, Byung Chul ^b   Hong, Young Soo ^c   Kim, Seong Jin ^a   Lee, Ho Jae ^a  

^a Gachon University College of Medicine   (South Korea)

^b Kangwon National University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Geldanamycin; Hsp70; Hsp90; Receptor degradation; TGF signaling

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 70; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BENZOQUINONES; CELL LINE; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITINATION;

EID: 76849109127     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.12.003     Document Type: Article

References (33)

1. Sharp S., Workman P. Adv. Cancer Res. 2006, 95:323-348.
2. Lindquist S., Craig E.A. Annu. Rev. Genet. 1988, 22:631-677.
3. Young J.C., Agashe V.R., Siegers K., Hartl F.U. Nat. Rev. Mol. Cell Biol. 2004, 5:781-791.
4. Wandinger S.K., Richter K., Buchner J. J. Biol. Chem. 2008, 283:18473-18477.
5. Pearl L.H., Prodromou C., Workman P. Biochem. J. 2008, 410:439-453.
6. Zou J., Gou Y., Guettouche T., Smith D.F., Voellmy R. Cell 1998, 94:471-480.
7. Richter K., Buchner J. J. Cell Physiol. 2001, 188:281-290.
8. Brown M.A., Zhu L., Schmidt C., Tucker P.W. Biochem. Biophys. Res. Commun. 2007, 363:241-246.
9. Bishop S.C., Burlison J.A., Blagg B.S. Curr. Cancer Drug Targets 2007, 7:369-388.
10. Massagué J. Annu. Rev. Cell Biol. 1990, 6:597-641.
11. Shi Y., Massagué J. Cell 2003, 113:685-700.
12. Massagué J., Blain S.W., Lo R.S. Cell 2000, 103:295-309.
13. Gordon K.J., Blobe G.C. Biochim. Biophys. Acta 2008, 1782:197-228.
14. Yingling J.M., Blanchard K.L., Sawyer J.S. Nat. Rev. Drug Discovery 2004, 3:1011-1022.
15. Bueno L., De Alwis D.P., Pitou C., Yingling J., Lahn M., Glatt S., Troconiz I.F. Eur. J. Cancer 2008, 44:142-150.
16. Xavier S., Piek E., Fujii M., Javelaud D., Mauviel A., Flanders K.C., Samuni A.M., Felici A., Reiss M., Yarkoni S., Sowers A., Mitchell J.B., Roberts A.B., Russo A. J. Biol. Chem. 2004, 279:15167-15176.
17. Feng X.H., Filvaroff E.H., Derynck R. J. Biol. Chem. 1995, 270:24237-24245.
18. Lee H.J., Yun C.H., Lim S.H., Kim B.C., Baik K.G., Kim J.M., Kim W.H., Kim S.J. Oncogene 2007, 26:173-185.
19. Zawel L., Dai J.L., Buckhaults P., Zhou S., Kinzler K.W., Vogelstein B., Kern S.E. Mol. Cell 1998, 1:611-617.
20. Dennler S., Itoh S., Vivien D., Ten Dijke P., Huet S., Gauthier J.M. EMBO J. 1998, 17:3091-3100.
21. Hocevar B.A., Brown T.L., Howe P.H. EMBO J. 1999, 18:1345-1356.
22. Lönn P., Morén A., Raja E., Dahl M., Moustakas A. Cell Res. 2009, 19:21-35.
23. Pratt W.B., Toft D.O. Exp. Biol. Med. (Maywood) 2003, 228:111-133.
24. Yokota S., Kitahara M., Nagata K. Cancer Res. 2000, 60:2942-2948.
25. Itoh S., Ten Dijke P. Curr. Opin. Cell Biol. 2007, 19:176-184.
26. Wrington K.H., Lin X., Feng X.H. Proc. Natl. Acad. Sci. USA 2008, 105:9244-9249.
27. Connell P., Ballinger C.A., Jiang J., Wu Y., Thompson L.J., Höhfeld J., Patterson C. Nat. Cell Biol. 2001, 3:93-96.
28. McDonough H., Patterson C. Cell Stress Chaperones. 2003, 8:303-308.
29. Díez-Fernández C., Andrés D., Cascales M. Free Radical Biol. Med. 2002, 33:835-846.
30. Mao H., Li Z., Zhou Y., Li Z., Zhuang S., An X., Zhang B., Chen W., Nie J., Wang Z., Borkan S.C., Wang Y., Yu X. Am. J. Physiol. Renal Physiol. 2008, 295:F202-F214.
31. Jolly C., Morimoto R.I. J. Natl. Cancer Inst. 2000, 92:1564-1572.
32. Daugaard M., Rodhe M., Jäättelä M. FEBS Lett. 2007, 581:3702-3710.
33. Seoane J. Clin. Transl. Oncol. 2008, 10:14-19.