Modelling the role of the Hsp70/Hsp90 system in the maintenance of protein homeostasis

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Proctor, Carole J ^a   Lorimer, Ian A J ^b,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEASOME; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; THEORETICAL MODEL;

ANIMALS; APOPTOSIS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MODELS, THEORETICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79960337702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022038     Document Type: Article

References (52)

1. Lansbury PT, Lashuel HA, (2006) A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 443: 774-779.
2. Bence NF, Sampat RM, Kopito RR, (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555.
3. Cadenas E, Davies KJA, (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radical Biology and Medicine 29: 222-230.
4. Zhu Y, Carvey PM, Ling Z, (2006) Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Research 1090: 35-44.
5. Friguet B, Bulteau A-L, Chondrogianni N, Conconi M, Petropoulos, (2000) Protein degradation by the proteasome and its implications in aging. The Annals of the New York Academy of Sciences 908: 143-154.
6. Szweda PA, Friguet B, Szweda LI, (2002) Proteolysis, free radicals, and aging. Free Radical Biology and Medicine 33: 29-36.
7. Sitte N, Merker K, Von Zglinicki T, Davies KJA, Grune T, (2000) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II- aging of nondividing cells. Faseb Journal 14: 2503-2510.
8. Sitte N, Merker K, Von Zglinicki T, Grune T, Davies KJA, (2000) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I- effects of proliferative senescence. Faseb Journal 14: 2495-2502.
9. Nardai G, Csermely P, Soti C, (2002) Chaperone function and chaperone overload in the aged. A preliminary analysis. Experimental Gerontology 37: 1257-1262.
10. Söti C, Csermely P, (2003) Aging and molecular chaperones. Experimental Gerontology 38: 1037-1040.
11. Dickey CA, Patterson C, Dickson D, Petrucelli L, (2007) Brain CHIP: removing the culprits in neurodegenerative disease. Trends in Molecular Medicine 13: 32-38.
12. Proctor CJ, Söti C, Boys RJ, Gillespie CS, Shanley DP, et al. (2005) Modelling the actions of chaperones and their role in ageing. Mechanisms of Ageing and Development 126: 119-131.
13. Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, et al. (2003) The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19: 524-531.
14. Zheng J, Edelman SW, Tharmarajah G, Walker DW, Pletcher SD, et al. (2005) Differential patterns of apoptosis in response to aging in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 102: 12083-12088.
15. Denu JM, Tanner KG, (1998) Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633-5642.
16. Passos JF, Nelson G, Wang C, Richter T, Simillion C, et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6: 347.
17. Koli K, Myllarniemi M, Keski-Oja J, Kinnula VL, (2008) Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 10: 333-342.
18. Torres M, Forman HJ, (2003) Redox signaling and the MAP kinase pathways. Biofactors 17: 287-296.
19. Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, et al. (2002) Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-39866.
20. Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA, (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
21. Csermely P, (2001) Chaperone overload is a possible contributor to 'civilization diseases'. Trends in Genetics 17: 701-704.
22. Sangster TA, Lindquist S, Queitsch C, (2004) Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays 26: 348-362.
23. Cowen LE, Lindquist S, (2005) Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309: 2185-2189.
24. Luo W, Sun W, Taldone T, Rodina A, Chiosis G, (2010) Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener 5: 24.
25. Hoops S, Sahle S, Gauges R, Lee C, Pahle Jr, et al. (2006) COPASI- a COmplex PAthway SImulator. Bioinformatics 22: 3067-3074.
26. Tang MY, Proctor CJ, Woulfe J, Gray DA, (2010) Experimental and computational analysis of polyglutamine-mediated cytotoxicity. PLoS Comput Biol 6: e1000944.
27. Beckman KB, Ames BN, (1998) The free radical theory of aging matures. Physiol Rev 78: 547-581.
28. Morimoto RI, (2008) Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes & Development 22: 1427-1438.
29. Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, et al. (2003) A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425: 407-410.
30. Lindner AB, Demarez A, (2009) Protein aggregation as a paradigm of aging. Biochim Biophys Acta 1790: 980-996.
31. Dickey CA, Koren J, Zhang Y-J, Xu Y-f, Jinwal UK, et al. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences 105: 3622-3627.
32. Proctor CJ, Tsirigotis M, Gray DA, (2007) An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline. BMC Systems Biology 1: 17.
33. Hernandez F, Avila J, (2008) The role of glycogen synthase kinase 3 in the early stages of Alzheimer's disease. FEBS letters 582: 3848-3854.
34. Hooper C, Killick R, Lovestone S, (2008) The GSK3 hypothesis of Alzheimer's disease. Journal of Neurochemistry 104: 1433-1439.
35. Bijur GN, Jope RS, (2001) Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3beta. J Biol Chem 276: 37436-37442.
36. Proctor CJ, Gray DA, (2010) GSK3 and p53- is there a link in Alzheimer's disease? Mol Neurodegener 5: 7.
37. Liu R-M, Choi J, Wu J-H, Gaston Pravia KA, Lewis KM, et al. (2010) Oxidative modification of nuclear mitogen-activated pKinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of Plasminogen Activator Inhibitor 1 in Fibroblasts. Journal of Biological Chemistry 285: 16239-16247.
38. Lee K-H, Lee C-T, Kim YW, Han SK, Shim Y-S, et al. (2005) Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. J Biol Chem 280: 13179-13186.
39. Wilkinson DJ, (2006) Stochastic Modelling for Systems Biology Chapman & Hall/CRC Press.
40. Kirkwood TBL, Boys RJ, Gillespie CS, Proctor CJ, Shanley DP, et al. (2003) Towards an e-biology of ageing: integrating theory and data. Nature Reviews Molecular Cell Biology 4: 243-249.
41. Gillespie DT, (1977) Exact stochastic simulation of coupled chemical reactions. The Journal of Physical Chemistry 31: 2340-2361.
42. BASIS website. Available: www.basis.ncl.ac.uk. Accessed 2011 June 20.
43. Biomodels database website. Available: www.ebi.ac.uk/biomodels/. Accessed 2011 June 20.
44. Le Novere N, Bornstein B, Broicher A, Courtot M, Donizelli M, et al. (2006) BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Research 34: D689-691.
45. Hendriks BS, Hua F, Chabot JR, (2008) Analysis of mechanistic pathway models in drug discovery: p38 pathway. Biotechnol Prog 24: 96-109.
46. Funahashi A, Matsuoka Y, Jouraku A, Morohashi M, Kikuchi N, et al. (2008) CellDesigner 3.5: A versatile modeling tool for biochemical networks. Proceedings of the IEEE 96: 1254-1265.
47. Kline MP, Morimoto RI, (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17: 2107-2115.
48. Interpro website. Available: http://www.ebi.ac.uk/interpro/. Accessed 2011 June 20.
49. Gene Ontology website. Available: http://www.geneontology.org/. Accessed 2011 June 20.
50. Chemical Entities of Biological Interest database (CHEBI) website. Availalbe: www.ebi.ac.uk/chebi. Accessed 2011 June 20.
51. UniProtKB/Swiss-Prot website. Available: http://www.ebi.uniprot.org/index.shtml. Accessed 2011 June 20.
52. Systems Biology Ontology website. Available: http://www.ebi.ac.uk/sbo/. Accessed 2011 June 20.