메뉴 건너뛰기




Volumn 14, Issue 10, 2013, Pages 1144-1149

From target therapy to miRNA therapeutics of human multiple myeloma: Theoretical and technological issues in the evolving scenario

Author keywords

Bone disease; MicroRNA; miRNA; Multiple myeloma; Non coding RNA; Target therapy

Indexed keywords

BORTEZOMIB; CATHEPSIN K; CYCLIN DEPENDENT KINASE 6; EXPORTIN 5; GELATINASE A; GELATINASE B; INTERLEUKIN 6; LET 7A; MICRORNA; MICRORNA 106B; MICRORNA 15; MICRORNA 155; MICRORNA 16; MICRORNA 181A; MICRORNA 181B; MICRORNA 192; MICRORNA 194; MICRORNA 215; MICRORNA 221; MICRORNA 222; MICRORNA 29B; MICRORNA 32; MICRORNA 34A; MICRORNA 382; NOTCH1 RECEPTOR; PROTEIN P53; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84881349597     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990186     Document Type: Review
Times cited : (45)

References (63)
  • 1
    • 0035342380 scopus 로고    scopus 로고
    • The role of the tyrosine kinase inhibitor STI571 in the treatment of cancer
    • O'Dwyer ME, Druker BJ. The role of the tyrosine kinase inhibitor STI571 in the treatment of cancer. Curr Cancer Drug Targets 2001; 1(1): 49-57.
    • (2001) Curr Cancer Drug Targets , vol.1 , Issue.1 , pp. 49-57
    • O'Dwyer, M.E.1    Druker, B.J.2
  • 2
    • 34447134867 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma
    • Younes H, Leleu X, Hatjiharissi E, et al. Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma. Clin Cancer Res 2007; 13(13): 3771-5.
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3771-3775
    • Younes, H.1    Leleu, X.2    Hatjiharissi, E.3
  • 3
    • 79952042047 scopus 로고    scopus 로고
    • Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: A multicentre, phase 1/2, open-label, dose-escalation study
    • Ghobrial IM, Weller E, Vij R, et al. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Lancet Oncol 2011; 12(3): 263-72.
    • (2011) Lancet Oncol , vol.12 , Issue.3 , pp. 263-272
    • Ghobrial, I.M.1    Weller, E.2    Vij, R.3
  • 4
    • 79959361375 scopus 로고    scopus 로고
    • A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma
    • Ghobrial IM, Munshi NC, Harris BN, et al. A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma. Am J Hematol 2011; 86(7): 573-8.
    • (2011) Am J Hematol , vol.86 , Issue.7 , pp. 573-578
    • Ghobrial, I.M.1    Munshi, N.C.2    Harris, B.N.3
  • 5
    • 84864322405 scopus 로고    scopus 로고
    • Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/ refractory multiple myeloma: A Phase I Multiple Myeloma Research Consortium study
    • Jakubowiak AJ, Richardson PG, Zimmerman T, et al. Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/ refractory multiple myeloma: a Phase I Multiple Myeloma Research Consortium study. Br J Haematol 2012; 158(4): 472-80.
    • (2012) Br J Haematol , vol.158 , Issue.4 , pp. 472-480
    • Jakubowiak, A.J.1    Richardson, P.G.2    Zimmerman, T.3
  • 6
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128(4): 683-92.
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 7
    • 76449105686 scopus 로고    scopus 로고
    • The potential role of epigenetic therapy in multiple myeloma
    • Smith EM, Boyd K, Davies FE. The potential role of epigenetic therapy in multiple myeloma. Br J Haematol 2010; 148(5): 702-13.
    • (2010) Br J Haematol , vol.148 , Issue.5 , pp. 702-713
    • Smith, E.M.1    Boyd, K.2    Davies, F.E.3
  • 8
    • 84876737132 scopus 로고    scopus 로고
    • New insights into the treatment of multiple myeloma with histone deacetylase inhibitors
    • Cea M, Cagnetta A, Gobbi M, et al. New insights into the treatment of multiple myeloma with histone deacetylase inhibitors. Curr Pharm Des 2013; 19(4): 734-44.
    • (2013) Curr Pharm Des , vol.19 , Issue.4 , pp. 734-744
    • Cea, M.1    Cagnetta, A.2    Gobbi, M.3
  • 10
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10(10): 704-14.
    • (2009) Nat Rev Genet , vol.10 , Issue.10 , pp. 704-714
    • Croce, C.M.1
  • 11
    • 84866410501 scopus 로고    scopus 로고
    • Promises and challenges of MicroRNA-based treatment of multiple myeloma
    • Tagliaferri P, Rossi M, Di Martino MT, et al. Promises and challenges of MicroRNA-based treatment of multiple myeloma. Curr Cancer Drug Targets 2012; 12(7): 838-46.
    • (2012) Curr Cancer Drug Targets , vol.12 , Issue.7 , pp. 838-846
    • Tagliaferri, P.1    Rossi, M.2    Di Martino, M.T.3
  • 12
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • Denli AM, Tops BB, Plasterk RH, et al. Processing of primary microRNAs by the Microprocessor complex. Nature 2004; 432(7014): 231-5.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3
  • 13
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • Gregory RI, Yan KP, Amuthan G, et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432(7014): 235-40.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3
  • 14
    • 0347988235 scopus 로고    scopus 로고
    • Nuclear export of microRNA precursors
    • Lund E, Guttinger S, Calado A, et al. Nuclear export of microRNA precursors. Science 2004; 303(5654): 95-8.
    • (2004) Science , vol.303 , Issue.5654 , pp. 95-98
    • Lund, E.1    Guttinger, S.2    Calado, A.3
  • 15
    • 27144550559 scopus 로고    scopus 로고
    • TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    • Haase AD, Jaskiewicz L, Zhang H, et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep 2005; 6(10): 961-7.
    • (2005) EMBO Rep , vol.6 , Issue.10 , pp. 961-967
    • Haase, A.D.1    Jaskiewicz, L.2    Zhang, H.3
  • 16
    • 58149103297 scopus 로고    scopus 로고
    • Deadenylation is a widespread effect of miRNA regulation
    • Eulalio A, Huntzinger E, Nishihara T, et al. Deadenylation is a widespread effect of miRNA regulation. RNA 2009; 15(1): 21-32.
    • (2009) RNA , vol.15 , Issue.1 , pp. 21-32
    • Eulalio, A.1    Huntzinger, E.2    Nishihara, T.3
  • 17
  • 18
    • 40449100030 scopus 로고    scopus 로고
    • Direct multiplexed measurement of gene expression with color-coded probe pairs
    • Geiss GK, Bumgarner RE, Birditt B, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 2008; 26(3): 317-25.
    • (2008) Nat Biotechnol , vol.26 , Issue.3 , pp. 317-325
    • Geiss, G.K.1    Bumgarner, R.E.2    Birditt, B.3
  • 19
    • 34249003938 scopus 로고    scopus 로고
    • Principles and limitations of computational microRNA gene and target finding
    • Lindow M, Gorodkin J. Principles and limitations of computational microRNA gene and target finding. DNA Cell Biol 2007; 26(5): 339-51.
    • (2007) DNA Cell Biol , vol.26 , Issue.5 , pp. 339-351
    • Lindow, M.1    Gorodkin, J.2
  • 20
    • 33745248430 scopus 로고    scopus 로고
    • microRNA target predictions in animals
    • Rajewsky N. microRNA target predictions in animals. Nat Genet. 2006; 38 Suppl: S8-13.
    • (2006) Nat Genet , vol.38 , Issue.SUPPL.
    • Rajewsky, N.1
  • 21
    • 33750318273 scopus 로고    scopus 로고
    • A guide through present computational approaches for the identification of mammalian microRNA targets
    • Sethupathy P, Megraw M, Hatzigeorgiou AG. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods 2006; 3(11): 881-6.
    • (2006) Nat Methods , vol.3 , Issue.11 , pp. 881-886
    • Sethupathy, P.1    Megraw, M.2    Hatzigeorgiou, A.G.3
  • 22
    • 77957766910 scopus 로고    scopus 로고
    • Desperately seeking microRNA targets
    • Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol 2010; 17(10): 1169-74.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.10 , pp. 1169-1174
    • Thomas, M.1    Lieberman, J.2    Lal, A.3
  • 23
    • 84867355784 scopus 로고    scopus 로고
    • MicroRNA-target interactions: New insights from genome-wide approaches
    • Lee D, Shin C. MicroRNA-target interactions: new insights from genome-wide approaches. Ann N Y Acad Sci 2012; 1271: 118-28.
    • (2012) Ann N Y Acad Sci , vol.1271 , pp. 118-128
    • Lee, D.1    Shin, C.2
  • 24
    • 84866425349 scopus 로고    scopus 로고
    • Editorial: New approaches in the treatment of multiple myeloma: From target-based agents to the new era of microRNAs (dedicated to the memory of Prof. Salvatore Venuta)
    • Tassone P, Tagliaferri P. Editorial: New approaches in the treatment of multiple myeloma: from target-based agents to the new era of microRNAs (dedicated to the memory of Prof. Salvatore Venuta). Curr Cancer Drug Targets 2012; 12(7): 741-2.
    • (2012) Curr Cancer Drug Targets , vol.12 , Issue.7 , pp. 741-742
    • Tassone, P.1    Tagliaferri, P.2
  • 25
    • 51349093465 scopus 로고    scopus 로고
    • MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
    • Pichiorri F, Suh SS, Ladetto M, et al. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA 2008; 105(35): 12885-90.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.35 , pp. 12885-12890
    • Pichiorri, F.1    Suh, S.S.2    Ladetto, M.3
  • 26
    • 77952340609 scopus 로고    scopus 로고
    • High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2
    • Zhou Y, Chen L, Barlogie B, et al. High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2. Proc Natl Acad Sci USA 2010; 107(17): 7904-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.17 , pp. 7904-7909
    • Zhou, Y.1    Chen, L.2    Barlogie, B.3
  • 27
    • 73949101367 scopus 로고    scopus 로고
    • Identification of microRNA expression patterns and definition of a microRNA/ mRNA regulatory network in distinct molecular groups of multiple myeloma
    • Lionetti M, Biasiolo M, Agnelli L, et al. Identification of microRNA expression patterns and definition of a microRNA/ mRNA regulatory network in distinct molecular groups of multiple myeloma. Blood 2009; 114(25): e20-6.
    • (2009) Blood , vol.114 , Issue.25
    • Lionetti, M.1    Biasiolo, M.2    Agnelli, L.3
  • 28
    • 84880309774 scopus 로고    scopus 로고
    • Improved risk stratification in myeloma using a microRNA-based classifier
    • Wu P, Agnelli L, Walker BA, et al. Improved risk stratification in myeloma using a microRNA-based classifier. Br J Haematol 2013; 162(3); 348-59.
    • (2013) Br J Haematol , vol.162 , Issue.3 , pp. 348-359
    • Wu, P.1    Agnelli, L.2    Walker, B.A.3
  • 29
    • 84879476643 scopus 로고    scopus 로고
    • Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia
    • Lionetti M, Musto P, Di Martino MT, et al. Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia. Clin Cancer Res 2013; 19(12): 3130-42.
    • (2013) Clin Cancer Res , vol.19 , Issue.12 , pp. 3130-3142
    • Lionetti, M.1    Musto, P.2    Di Martino, M.T.3
  • 30
    • 69249225706 scopus 로고    scopus 로고
    • MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
    • Roccaro AM, Sacco A, Thompson B, et al. MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma. Blood 2009; 113(26): 6669-80.
    • (2009) Blood , vol.113 , Issue.26 , pp. 6669-6680
    • Roccaro, A.M.1    Sacco, A.2    Thompson, B.3
  • 31
    • 84866415670 scopus 로고    scopus 로고
    • MicroRNAs in the pathobiology of multiple myeloma
    • Lionetti M, Agnelli L, Lombardi L, et al. MicroRNAs in the pathobiology of multiple myeloma. Curr Cancer Drug Targets 2012; 12(7): 823-37.
    • (2012) Curr Cancer Drug Targets , vol.12 , Issue.7 , pp. 823-837
    • Lionetti, M.1    Agnelli, L.2    Lombardi, L.3
  • 32
    • 77957936826 scopus 로고    scopus 로고
    • Downregulation of p53- inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development
    • Pichiorri F, Suh SS, Rocci A, et al. Downregulation of p53- inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 2010; 18(4): 367-81.
    • (2010) Cancer Cell , vol.18 , Issue.4 , pp. 367-381
    • Pichiorri, F.1    Suh, S.S.2    Rocci, A.3
  • 33
    • 34548039517 scopus 로고    scopus 로고
    • Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3- mediated induction of microRNA-21 through a highly conserved enhancer
    • Loffler D, Brocke-Heidrich K, Pfeifer G, et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3- mediated induction of microRNA-21 through a highly conserved enhancer. Blood 2007; 110(4): 1330-3.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1330-1333
    • Loffler, D.1    Brocke-Heidrich, K.2    Pfeifer, G.3
  • 34
    • 79952356831 scopus 로고    scopus 로고
    • Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients
    • Sarasquete ME, Gutierrez NC, Misiewicz-Krzeminska I, et al. Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients. Haematologica 2011; 96(3): 468-71.
    • (2011) Haematologica , vol.96 , Issue.3 , pp. 468-471
    • Sarasquete, M.E.1    Gutierrez, N.C.2    Misiewicz-Krzeminska, I.3
  • 35
    • 33947198771 scopus 로고    scopus 로고
    • Overexpression of Dicer in precursor lesions of lung adenocarcinoma
    • Chiosea S, Jelezcova E, Chandran U, et al. Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res 2007; 67(5): 2345-50.
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2345-2350
    • Chiosea, S.1    Jelezcova, E.2    Chandran, U.3
  • 36
    • 58049213696 scopus 로고    scopus 로고
    • Dicer, Drosha, and outcomes in patients with ovarian cancer
    • Merritt WM, Lin YG, Han LY, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 2008; 359(25): 2641-50.
    • (2008) N Engl J Med , vol.359 , Issue.25 , pp. 2641-2650
    • Merritt, W.M.1    Lin, Y.G.2    Han, L.Y.3
  • 37
    • 70350584700 scopus 로고    scopus 로고
    • RNA interference and micro RNA-oriented therapy in cancer: Rationales, promises, and challenges
    • Duchaine TF, Slack FJ. RNA interference and micro RNA-oriented therapy in cancer: rationales, promises, and challenges. Curr Oncol 2009; 16(4): 61-6.
    • (2009) Curr Oncol , vol.16 , Issue.4 , pp. 61-66
    • Duchaine, T.F.1    Slack, F.J.2
  • 38
    • 0032544134 scopus 로고    scopus 로고
    • The first analogues of LNA (locked nucleic acids): Phosphorothioate-LNA and 2'-thio- LNA
    • Kumar R, Singh SK, Koshkin AA, et al. The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio- LNA. Bioorg Med Chem Lett 1998; 8(16): 2219-22.
    • (1998) Bioorg Med Chem Lett , vol.8 , Issue.16 , pp. 2219-2222
    • Kumar, R.1    Singh, S.K.2    Koshkin, A.A.3
  • 39
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
    • Braasch DA, Corey DR. Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA. Chem Biol 2001; 8(1): 1-7.
    • (2001) Chem Biol , vol.8 , Issue.1 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 40
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005; 438(7068): 685-9.
    • (2005) Nature , vol.438 , Issue.7068 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 41
    • 84865403336 scopus 로고    scopus 로고
    • LNA-mediated antimiR- 155 silencing in low-grade B-cell lymphomas
    • Zhang Y, Roccaro AM, Rombaoa C, et al. LNA-mediated antimiR- 155 silencing in low-grade B-cell lymphomas. Blood 2012; 120(8): 1678-86.
    • (2012) Blood , vol.120 , Issue.8 , pp. 1678-1686
    • Zhang, Y.1    Roccaro, A.M.2    Rombaoa, C.3
  • 42
    • 84877258007 scopus 로고    scopus 로고
    • Treatment of HCV Infection by Targeting MicroRNA
    • Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV Infection by Targeting MicroRNA. N Engl J Med 2013; 368(18): 1685-94.
    • (2013) N Engl J Med , vol.368 , Issue.18 , pp. 1685-1694
    • Janssen, H.L.1    Reesink, H.W.2    Lawitz, E.J.3
  • 44
    • 77955022405 scopus 로고    scopus 로고
    • Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
    • Wiggins JF, Ruffino L, Kelnar K, et al. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 2010; 70(14): 5923-30.
    • (2010) Cancer Res , vol.70 , Issue.14 , pp. 5923-5930
    • Wiggins, J.F.1    Ruffino, L.2    Kelnar, K.3
  • 45
    • 77949658280 scopus 로고    scopus 로고
    • Regression of murine lung tumors by the let-7 microRNA
    • Trang P, Medina PP, Wiggins JF, et al. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2010; 29(11): 1580-7.
    • (2010) Oncogene , vol.29 , Issue.11 , pp. 1580-1587
    • Trang, P.1    Medina, P.P.2    Wiggins, J.F.3
  • 46
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro AM, Sacco A, Maiso P, et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest 2013; 123(4): 1542-55.
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3
  • 47
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10(12): 1470-6.
    • (2008) Nat Cell Biol , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    van Rijn, S.3
  • 48
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9(6): 654-9.
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3
  • 49
    • 84869238270 scopus 로고    scopus 로고
    • Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: In vitro and in vivo evidence
    • Di Martino MT, Leone E, Amodio N, et al. Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. Clin Cancer Res 2012; 18(22): 6260-70.
    • (2012) Clin Cancer Res , vol.18 , Issue.22 , pp. 6260-6270
    • Di Martino, M.T.1    Leone, E.2    Amodio, N.3
  • 50
    • 79954436115 scopus 로고    scopus 로고
    • A unique threedimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells
    • Calimeri T, Battista E, Conforti F, et al. A unique threedimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells. Leukemia 2011; 25(4): 707-11.
    • (2011) Leukemia , vol.25 , Issue.4 , pp. 707-711
    • Calimeri, T.1    Battista, E.2    Conforti, F.3
  • 51
    • 84871694384 scopus 로고    scopus 로고
    • DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma
    • Amodio N, Leotta M, Bellizzi D, et al. DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma. Oncotarget 2012; 3(10): 1246-58.
    • (2012) Oncotarget , vol.3 , Issue.10 , pp. 1246-1258
    • Amodio, N.1    Leotta, M.2    Bellizzi, D.3
  • 52
    • 84870543762 scopus 로고    scopus 로고
    • miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop of the the transcription factor Sp1
    • Amodio N, Di Martino MT, Foresta U et al. miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop of the the transcription factor Sp1. Cell Death Dis 2012; 3: e436.
    • (2012) Cell Death Dis , vol.3
    • Amodio, N.1    Di Martino, M.T.2    Foresta, U.3
  • 53
    • 84866434864 scopus 로고    scopus 로고
    • Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma
    • Tassone P, Neri P, Burger R, et al. Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma. Curr Cancer Drug Targets 2012; 12(7): 814-22.
    • (2012) Curr Cancer Drug Targets , vol.12 , Issue.7 , pp. 814-822
    • Tassone, P.1    Neri, P.2    Burger, R.3
  • 54
    • 84877100047 scopus 로고    scopus 로고
    • Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth
    • Leone E, Morelli E, Di Martino MT, et al. Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. Clin Cancer Res 2013; 19(8): 2096-106.
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2096-2106
    • Leone, E.1    Morelli, E.2    Di Martino, M.T.3
  • 55
    • 84875766140 scopus 로고    scopus 로고
    • In vitro and in vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma
    • Di Martino MT, Gulla A, Cantafio ME, et al. In vitro and in vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma. Oncotarget 2013; 4(2): 242-55.
    • (2013) Oncotarget , vol.4 , Issue.2 , pp. 242-255
    • Di Martino, M.T.1    Gulla, A.2    Cantafio, M.E.3
  • 56
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
    • Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 2001; 27(3): 165-76.
    • (2001) Cancer Treat Rev , vol.27 , Issue.3 , pp. 165-176
    • Coleman, R.E.1
  • 57
    • 83455225056 scopus 로고    scopus 로고
    • The skeleton: A multifunctional complex organ: The role of key signalling pathways in osteoclast differentiation and in bone resorption
    • Mellis DJ, Itzstein C, Helfrich MH, et al. The skeleton: a multifunctional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption. J Endocrinol 2011; 211(2): 131-43.
    • (2011) J Endocrinol , vol.211 , Issue.2 , pp. 131-143
    • Mellis, D.J.1    Itzstein, C.2    Helfrich, M.H.3
  • 58
    • 53449089919 scopus 로고    scopus 로고
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    • Dhodapkar KM, Barbuto S, Matthews P, et al. Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 2008; 112(7): 2878-85.
    • (2008) Blood , vol.112 , Issue.7 , pp. 2878-2885
    • Dhodapkar, K.M.1    Barbuto, S.2    Matthews, P.3
  • 59
    • 78149322663 scopus 로고    scopus 로고
    • A novel role of IL-17- producing lymphocytes in mediating lytic bone disease in multiple myeloma
    • Noonan K, Marchionni L, Anderson J, et al. A novel role of IL-17- producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 2010; 116(18): 3554-63.
    • (2010) Blood , vol.116 , Issue.18 , pp. 3554-3563
    • Noonan, K.1    Marchionni, L.2    Anderson, J.3
  • 60
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: Therapeutic applications
    • Hideshima T, Chauhan D, Schlossman R, et al. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001; 20(33): 4519-27.
    • (2001) Oncogene , vol.20 , Issue.33 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3
  • 61
    • 84875764502 scopus 로고    scopus 로고
    • miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease
    • Rossi M, Pitari MR, Amodio N, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 2012.
    • (2012) J Cell Physiol
    • Rossi, M.1    Pitari, M.R.2    Amodio, N.3
  • 62
    • 84866596352 scopus 로고    scopus 로고
    • Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF
    • Zhang J, Zhao H, Chen J, et al. Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF. FEBS Lett 2012; 586(19): 3255-62.
    • (2012) FEBS Lett , vol.586 , Issue.19 , pp. 3255-3262
    • Zhang, J.1    Zhao, H.2    Chen, J.3
  • 63
    • 82155163802 scopus 로고    scopus 로고
    • MicroRNA biogenesis and regulation of bone remodeling
    • Kapinas K, Delany AM. MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther 2011; 13(3): 220.
    • (2011) Arthritis Res Ther , vol.13 , Issue.3 , pp. 220
    • Kapinas, K.1    Delany, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.