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Volumn 3, Issue 10, 2012, Pages 1246-1258

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

Author keywords

DNA methyltransferases; DNMT; MicroRNA; Mir 29b; Multiple myeloma

Indexed keywords

AZACITIDINE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; MICRORNA 29B;

EID: 84871694384     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.675     Document Type: Article
Times cited : (139)

References (55)
  • 2
    • 84860219443 scopus 로고    scopus 로고
    • The genetic architecture of multiple myeloma
    • Morgan GJ, Walker BA and Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012; 12(5):335-348.
    • (2012) Nat Rev Cancer. , vol.12 , Issue.5 , pp. 335-348
    • Morgan, G.J.1    Walker, B.A.2    Davies, F.E.3
  • 6
    • 84866423778 scopus 로고    scopus 로고
    • Targeted therapy of multiple myeloma: The changing paradigm at the beginning of the new millennium
    • Morabito F, Recchia AG, Mazzone C and Gentile M. Targeted therapy of multiple myeloma: the changing paradigm at the beginning of the new millennium. Curr Cancer Drug Targets. 2012; 12(7):743-756.
    • (2012) Curr Cancer Drug Targets. , vol.12 , Issue.7 , pp. 743-756
    • Morabito, F.1    Recchia, A.G.2    Mazzone, C.3    Gentile, M.4
  • 7
    • 80052887167 scopus 로고    scopus 로고
    • A critical role for the NFkB pathway in multiple myeloma
    • Demchenko YN and Kuehl WM. A critical role for the NFkB pathway in multiple myeloma. Oncotarget. 2010; 1(1):59-68.
    • (2010) Oncotarget. , vol.1 , Issue.1 , pp. 59-68
    • Demchenko, Y.N.1    Kuehl, W.M.2
  • 9
    • 30844462355 scopus 로고    scopus 로고
    • The fundamental role of epigenetics in hematopoietic malignancies
    • Galm O, Herman JG and Baylin SB. The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev. 2006; 20(1):1-13.
    • (2006) Blood Rev. , vol.20 , Issue.1 , pp. 1-13
    • Galm, O.1    Herman, J.G.2    Baylin, S.B.3
  • 10
    • 0042329754 scopus 로고    scopus 로고
    • Structure, function and evolution of CpG island promoters
    • Antequera F. Structure, function and evolution of CpG island promoters. Cell Mol Life Sci. 2003; 60(8):1647-1658.
    • (2003) Cell Mol Life Sci. , vol.60 , Issue.8 , pp. 1647-1658
    • Antequera, F.1
  • 11
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA and Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002; 3(6):415-428.
    • (2002) Nat Rev Genet. , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 12
    • 0035962631 scopus 로고    scopus 로고
    • DNA methylation, methyltransferases, and cancer
    • Robertson KD. DNA methylation, methyltransferases, and cancer. Oncogene. 2001; 20(24):3139-3155.
    • (2001) Oncogene. , vol.20 , Issue.24 , pp. 3139-3155
    • Robertson, K.D.1
  • 13
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000; 9(16):2395-2402.
    • (2000) Hum Mol Genet. , vol.9 , Issue.16 , pp. 2395-2402
    • Bestor, T.H.1
  • 14
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA and Jones PA. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999; 27(11):2291-2298.
    • (1999) Nucleic Acids Res. , vol.27 , Issue.11 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5    Gonzales, F.A.6    Jones, P.A.7
  • 15
    • 0033555953 scopus 로고    scopus 로고
    • Role of DNA 5-methylcytosine transferase in cell transformation by fos
    • Bakin AV and Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science. 1999; 283(5400):387-390.
    • (1999) Science. , vol.283 , Issue.5400 , pp. 387-390
    • Bakin, A.V.1    Curran, T.2
  • 16
    • 0033538072 scopus 로고    scopus 로고
    • DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen
    • Slack A, Cervoni N, Pinard M and Szyf M. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem. 1999; 274(15):10105-10112.
    • (1999) J Biol Chem. , vol.274 , Issue.15 , pp. 10105-10112
    • Slack, A.1    Cervoni, N.2    Pinard, M.3    Szyf, M.4
  • 17
    • 0034658196 scopus 로고    scopus 로고
    • Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells
    • Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M and Jones PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res. 2000; 28(10):2108-2113.
    • (2000) Nucleic Acids Res. , vol.28 , Issue.10 , pp. 2108-2113
    • Robertson, K.D.1    Keyomarsi, K.2    Gonzales, F.A.3    Velicescu, M.4    Jones, P.A.5
  • 20
    • 18144419362 scopus 로고    scopus 로고
    • Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway
    • McCabe MT, Davis JN and Day ML. Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. Cancer Res. 2005; 65(9):3624-3632.
    • (2005) Cancer Res. , vol.65 , Issue.9 , pp. 3624-3632
    • McCabe, M.T.1    Davis, J.N.2    Day, M.L.3
  • 22
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    • Baylin SB and Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000; 16(4):168-174.
    • (2000) Trends Genet. , vol.16 , Issue.4 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 23
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA and Jones PA. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006; 9(6):435-443.
    • (2006) Cancer Cell. , vol.9 , Issue.6 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3    Friedman, J.M.4    Chuang, J.C.5    Coetzee, G.A.6    Jones, P.A.7
  • 25
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-297.
    • (2004) Cell. , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 28
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, Weidhaas JB, Bader AG and Slack FJ. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther. 2011; 19(6):1116-1122.
    • (2011) Mol Ther. , vol.19 , Issue.6 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3    Cho, C.4    Omotola, M.5    Brown, D.6    Weidhaas, J.B.7    Bader, A.G.8    Slack, F.J.9
  • 34
    • 36949016699 scopus 로고    scopus 로고
    • Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
    • Kanai Y and Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis. 2007; 28(12):2434-2442.
    • (2007) Carcinogenesis. , vol.28 , Issue.12 , pp. 2434-2442
    • Kanai, Y.1    Hirohashi, S.2
  • 35
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y and Sasaki H. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood. 2001; 97(5):1172-1179.
    • (2001) Blood. , vol.97 , Issue.5 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3    Akashi, K.4    Fukumaki, Y.5    Niho, Y.6    Sasaki, H.7
  • 36
    • 0033566973 scopus 로고    scopus 로고
    • Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
    • De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X and Nelson WG. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res. 1999; 59(16):3855-3860.
    • (1999) Cancer Res. , vol.59 , Issue.16 , pp. 3855-3860
    • De Marzo, A.M.1    Marchi, V.L.2    Yang, E.S.3    Veeraswamy, R.4    Lin, X.5    Nelson, W.G.6
  • 37
    • 78049515403 scopus 로고    scopus 로고
    • Overexpression of DNA methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis
    • Qu Y, Mu G, Wu Y, Dai X, Zhou F, Xu X, Wang Y and Wei F. Overexpression of DNA methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis. Am J Clin Pathol. 2010; 134(5):826-834.
    • (2010) Am J Clin Pathol. , vol.134 , Issue.5 , pp. 826-834
    • Qu, Y.1    Mu, G.2    Wu, Y.3    Dai, X.4    Zhou, F.5    Xu, X.6    Wang, Y.7    Wei, F.8
  • 39
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • Galm O, Yoshikawa H, Esteller M, Osieka R and Herman JG. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood. 2003; 101(7):2784-2788.
    • (2003) Blood. , vol.101 , Issue.7 , pp. 2784-2788
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.G.5
  • 42
    • 0030940091 scopus 로고    scopus 로고
    • Frequent hypermethylation of p16 and p15 genes in multiple myeloma
    • Ng MH, Chung YF, Lo KW, Wickham NW, Lee JC and Huang DP. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood. 1997; 89(7):2500-2506.
    • (1997) Blood. , vol.89 , Issue.7 , pp. 2500-2506
    • Ng, M.H.1    Chung, Y.F.2    Lo, K.W.3    Wickham, N.W.4    Lee, J.C.5    Huang, D.P.6
  • 43
    • 69149109764 scopus 로고    scopus 로고
    • Von Hippel-Lindau methylation status in patients with multiple myeloma: a potential predictive factor for the development of bone disease
    • Hatzimichael E, Dranitsaris G, Dasoula A, Benetatos L, Stebbing J, Crook T and Bourantas KL. Von Hippel-Lindau methylation status in patients with multiple myeloma: a potential predictive factor for the development of bone disease. Clin Lymphoma Myeloma. 2009; 9(3):239-242.
    • (2009) Clin Lymphoma Myeloma. , vol.9 , Issue.3 , pp. 239-242
    • Hatzimichael, E.1    Dranitsaris, G.2    Dasoula, A.3    Benetatos, L.4    Stebbing, J.5    Crook, T.6    Bourantas, K.L.7
  • 46
    • 79955070135 scopus 로고    scopus 로고
    • Is miR-29 an oncogene or tumor suppressor in CLL
    • Pekarsky Y and Croce CM. Is miR-29 an oncogene or tumor suppressor in CLL? Oncotarget. 2010; 1(3):224-227.
    • (2010) Oncotarget , vol.1 , Issue.3 , pp. 224-227
    • Pekarsky, Y.1    Croce, C.M.2
  • 52
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25(4):402-408.
    • (2001) Methods. , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.