RNA interference and micro-RNA-oriented therapy in cancer: Rationales, promises, and challenges

Current Oncology

Volumn 16, Issue 4, 2009, Pages 61-66

  Duchaine, Thomas F ^a   Slack, F J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b YALE UNIVERSITY   (United States)

Author keywords

Cancer therapy; miRNA; Nucleic acid analogs; Oncomirs; RNAi therapy; siRNA; Tumour suppressor miRNAs

Indexed keywords

ANTINEOPLASTIC AGENT; DICER; LOCKED NUCLEIC ACID; MESSENGER RNA; MICRORNA; MICRORNA INHIBITOR; PLEIOTROPHIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

CANCER THERAPY; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; HUMAN; NONHUMAN; REVIEW; RNA INTERFERENCE;

EID: 70350584700     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Banerjee D, Slack F. Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression. Bioessays 2002;24:119-129 (Pubitemid 34179290)
2. Grosshans H, Slack FJ. Micro-RNAs: small is plentiful. J Cell Biol 2002;156:17-22.
3. Niwa R, Slack FJ. The evolution of animal microRNA function. Curr Opin Genet Dev 2007;17:145-150
4. Boehm M, Slack F. A developmental timing microRNA and its target regulate life span in C. elegans. Science 2005;310:1954-1957
5. Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005;120:635-647 (Pubitemid 40343076)
6. Filipowicz W. RNAi: the nuts and bolts of the risc machine. Cell 2005;122:17-20. (Pubitemid 40977936)
7. Jaskiewicz L, Filipowicz W. Role of Dicer in posttranscriptional rna silencing. Curr Top Microbiol Immunol 2008;320:77-97.
8. Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009;136:642-655
9. Pratt AJ, Macrae IJ. The RNA induced silencing complex: a versatile gene-silencing machine. J Biol Chem 2009;[Epub ahead of print].
10. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-498 (Pubitemid 32494397)
11. Liu J, Carmell MA, Rivas FV, et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 2004;305:1437-1441 (Pubitemid 39167657)
12. Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009;10:126-139
13. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008;9:102-114
14. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.
15. Wang Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ. Structure of an Argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 2008;456:921-926
16. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115:787-798
17. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297
18. Reinhart B, Slack F, Basson M, et al. The 21 nucleotide let-7 RNA regulates C. elegans developmental timing. Nature 2000;403:901-906 (Pubitemid 30130993)
19. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 2004;101:2999-3004. (Pubitemid 38327724)
20. Meltzer PS. Cancer genomics: small RNAs with big impacts. Nature 2005;435:745-746 (Pubitemid 40839710)
21. Voorhoeve PM, le Sage C, Schrier M, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006;124:1169-1181
22. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated micrornas modulate E2F1 expression. Nature 2005;435:839-843
23. He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005;435:828-833 (Pubitemid 40839734)
24. Calin GA, Croce CM. MicroRNA - cancer connection: the beginning of a new tale. Cancer Res 2006;66:7390-7394
25. de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007;6:443-453 (Pubitemid 47064567)
26. Whitehead KA, Langer R, Anderson DG. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009;8:129-138
27. Grzelinski M, Urban-Klein B, Martens T, et al. RNA interference - mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoural effects in glioblastoma xenografts. Hum Gene Ther 2006;17:751-766 (Pubitemid 44100720)
28. Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of Ews-Fli1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005;65:8984-8992 (Pubitemid 41377390)
29. Weidhaas JB, Babar I, Nallur SM, et al. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 2007;67:11111-11116 (Pubitemid 350248533)
30. Slack FJ, Weidhaas JB. MicroRNAs as a potential magic bullet in cancer. Future Oncol 2006;2:73-82.
31. Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW. A microRNA imparts robustness against environmental fluctuation during development. Cell 2009;137:273-282
32. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009.
33. Esquela-Kerscher A, Trang P, Wiggins JF, et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008;7:759-764
34. Kumar MS, Erkeland SJ, Pester RE, et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A 2008;105:3903-3908
35. Kota J, Chivukula RR, O'Donnell KA, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009;137:1005-1017
36. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with "antagomirs." Nature 2005;438:685-689
37. Meister G, Landthaler M, Dorsett Y, Tuschl T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 2004;10:544-550 (Pubitemid 38241013)
38. Hutvagner G, Simard MJ, Mello CC, Zamore PD. Sequence-specific inhibition of small RNA function. PLoS Biol 2004;2:E98.
39. Davis S, Propp S, Freier SM, et al. Potent inhibition of microRNA in vivo without degradation. Nucleic Acids Res 2009;37:70-77
40. Davis S, Lollo B, Freier S, Esau C. Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res 2006;34:2294-2304 (Pubitemid 43985667)
41. Elmen J, Lindow M, Schutz S, et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008;452:896-899 (Pubitemid 351550859)
42. Chang J, Guo JT, Jiang D, Guo H, Taylor JM, Block TM. Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol 2008;82:8215-8223
43. Stenvang J, Silahtaroglu AN, Lindow M, Elmen J, Kauppinen S. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol 2008;18:89-102.
44. DeVincenzo J, Cehelsky JE, Alvarez R, et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res 2008;77:225-231
45. Fattal E, Bochot A. Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA. Adv Drug Deliv Rev 2006;58:1203-1223 (Pubitemid 44778909)
46. Kleinman ME, Yamada K, Takeda A, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008;452:591-597
47. Jackson AL, Linsley PS. Noise amidst the silence: off-target effects of siRNAs? Trends Genet 2004;20:521-524
48. Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-637 (Pubitemid 36638089)
49. Farh KK, Grimson A, Jan C, et al. The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science 2005;310:1817-1821 (Pubitemid 41814382)