Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation

Protein Science

Volumn 22, Issue 8, 2013, Pages 1037-1048

  Barre, Patrick ^a   Eliezer, David ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Alzheimer's; Amyloid; Microtubule binding domain; Microtubule binding repeat; Paired helical filaments; PHF6; Protein aggregation; Tau

Indexed keywords

FATTY ACID; HEXAPEPTIDE; TAU PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL PARAMETERS; CIRCULAR DICHROISM; MICROTUBULE; MOLECULAR DYNAMICS; NEUROFIBRILLARY TANGLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

ALZHEIMER'S; AMYLOID; MICROTUBULE-BINDING DOMAIN; MICROTUBULE-BINDING REPEAT; PAIRED HELICAL FILAMENTS; PHF6; PHF6*; PROTEIN AGGREGATION; TAU;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; MICELLES; MICROTUBULES; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TAU PROTEINS;

EID: 84881305046     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2290     Document Type: Article

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