Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells

Journal of Biological Chemistry

Volumn 288, Issue 31, 2013, Pages 22516-22526

  Asthana, Jayant ^a   Kapoor, Sonia ^a   Mohan, Renu ^a   Panda, Dulal ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CAUSAL RELATIONSHIPS; DEACETYLASE; DEACETYLASE ACTIVITY; MCF-7 CELLS; MICROTUBULE DYNAMICS; MICROTUBULE STABILITY; MICROTUBULES; PHARMACOLOGICAL INHIBITION;

ACETYLATION;

STABILITY;

HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; NOCODAZOLE; SMALL INTERFERING RNA; TRICHOSTATIN A; TUBASTATIN A; TUBULIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL STRAIN MCF 7; COLD; CONTROLLED STUDY; DEPOLYMERIZATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REPRESSION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEPLETION; REGULATORY MECHANISM;

HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITORS; MAPS; MICROTUBULE DYNAMICS; MICROTUBULES; POST-TRANSLATIONAL MODIFICATION; TUBASTATIN A; TUBULIN ACETYLATION;

ACETYLATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INDOLES; MCF-7 CELLS; MICROTUBULES; RNA, SMALL INTERFERING;

EID: 84881222631     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489328     Document Type: Article

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