Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: Effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 8, 2013, Pages 1235-1241

  Dadsetan, Sherry ^a   Kukolj, Eva ^a,c   Bak, Lasse K ^a   Sørensen, Michael ^b   Ott, Peter ^b   Vilstrup, Hendrik ^b   Schousboe, Arne ^a   Keiding, Susanne ^b   Waagepetersen, Helle S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c MAX F PERUTZ LABORATORIES   (Austria)

Author keywords

alanine; hepatic encephalopathy; hyperammonemia; methionine sulfoximine

Indexed keywords

ALANINE; AMMONIA; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GABAERGIC SYSTEM; HEPATIC ENCEPHALOPATHY; HYPERAMMONEMIA; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ALANINE; AMINO ACIDS; AMMONIA; ANIMALS; ASTROCYTES; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; ENZYME INHIBITORS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMATE-AMMONIA LIGASE; HYPERAMMONEMIA; METHIONINE SULFOXIMINE; NEURONS; RATS; RATS, WISTAR;

EID: 84881168543     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.73     Document Type: Article

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