The endothelin a receptor mediates fibrocyte differentiation in chronic obstructive asthma the involvement of connective tissue growth factor

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 3, 2013, Pages 298-308

  Weng, Chih Ming ^a   Chen, Bing Chang ^a   Wang, Chun Hua ^b   Feng, Po Hao ^b   Lee, Meng Jung ^b   Huang, Chien Da ^b   Kuo, Han Pin ^a,b   Lin, Chien Huang ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

A smooth muscle actin; Chronic obstructive asthma; Connective tissue growth factor; Endothelin A receptor; Fibrocyte

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; CD45 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; CORTICOSTEROID; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; FLUTICASONE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SALMETEROL;

ADULT; ARTICLE; ASTHMA; BLOOD LEVEL; BRONCHUS; CELL DIFFERENTIATION; CELL ISOLATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG FIBROSIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ASTHMA; BRONCHI; CELL DIFFERENTIATION; CELLS, CULTURED; CHRONIC DISEASE; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE PROGRESSION; FEMALE; FIBROBLASTS; FIBROSIS; FLOW CYTOMETRY; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PROGNOSIS; PULMONARY FIBROSIS; RECEPTOR, ENDOTHELIN A;

EID: 84881119797     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201301-0132OC     Document Type: Article

References (46)

1. Fish JE, Peters SP. Airway remodeling and persistent airway obstruction in asthma. J Allergy Clin Immunol 1999;104:509-516.
2. Bergeron C, Al-Ramli W, Hamid Q. Remodeling in asthma. Proc Am Thorac Soc 2009;6:301-305.
3. Redington AE. Fibrosis and airway remodelling. Clin Exp Allergy 2000; 30:42-45.
4. Sumi Y, Hamid Q. Airway remodeling in asthma. Allergol Int 2007;56: 341-348.
5. Halwani R, Al-Muhsen S, Hamid Q. Airway remodeling in asthma. Curr Opin Pharmacol 2010;10:236-245.
6. Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007;87:858-870.
7. Moeller A, Gilpin SE, Ask K, Cox G, Cook D, Gauldie J, Margetts PJ, Farkas L, Dobranowski J, Boylan C, et al. Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009;179:588-594.
8. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003;171:380-389.
9. Nihlberg K, Larsen K, Hultgardh-Nilsson A, Malmstrom A, Bjermer L, Westergren-Thorsson G. Tissue fibrocytes in patients with mild asthma: A possible link to thickness of reticular basement membrane? Respir Res 2006;7:50.
10. Strieter RM, Keeley EC, Hughes MA, Burdick MD, Mehrad B. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 2009;86:1111-1118.
11. Mehrad B, Burdick MD, Strieter RM. Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol 2009;41:1708-1718.
12. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004;114:438-446.
13. Keeley EC, Mehrad B, Strieter RM. The role of fibrocytes in fibrotic diseases of the lungs and heart. Fibrogenesis Tissue Repair 2011;4:2.
14. Wang CH, Huang CD, Lin HC, Lee KY, Lin SM, Liu CY, Huang KH, Ko YS, Chung KF, Kuo HP. Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med 2008;178:583-591.
15. Wang CH, Huang CD, Lin HC, Huang TT, Lee KY, Lo YL, Lin SM, Chung KF, Kuo HP. Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J Allergy Clin Immunol 2012;129: 1367-1376.
16. Goldie RG, Knott PG, Carr MJ, Hay DW, Henry PJ. The endothelins in the pulmonary system. Pulm Pharmacol 1996;9:69-93.
17. Spiropoulos K, Trakada G, Nikolaou E, Prodromakis E, Efremidis G, Pouli A, Koniavitou A. Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma. Respir Med 2003;97:983-989.
18. Aoki T, Kojima T, Ono A, Unishi G, Yoshijima S, Kameda-Hayashi N, Yamamoto C, Hirata Y, Kobayashi Y. Circulating endothelin-1 levels in patients with bronchial asthma. Ann Allergy 1994;73:365-369.
19. Leask A. Targeting the TGF-beta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. Cell Signal 2008;20:1409-1414.
20. Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a Rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004;15:2707-2719.
21. Park SH, Saleh D, Giaid A, Michel RP. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am J Respir Crit Care Med 1997;156:600-608.
22. Swigris JJ, Brown KK. The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis. BioDrugs 2010;24:49-54.
23. Manetti M, Neumann E, Milia AF, Tarner IH, Bechi P, Matucci-Cerinic M, Ibba-Manneschi L, Muller-Ladner U. Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients. Arthritis Rheum 2007;56:3442-3447.
24. Rodriguez-Vita J, Ruiz-Ortega M, Ruperez M, Esteban V, Sanchez-Lopez E, Plaza JJ, Egido J. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res 2005;97:125-134.
25. Shi-wen X, Kennedy L, Renzoni EA, Bou-Gharios G, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A. Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum 2007;56:4189-4194.
26. Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004;279:23098-23103.
27. Perbal B. CCN proteins: Multifunctional signalling regulators. Lancet 2004;363:62-64.
28. Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy? Matrix Biol 2002;21:473-482.
29. Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ. The control of CCN2 (CTGF) gene expression in normal and scleroderma fibroblasts. Mol Pathol 2001;54:180-183.
30. Brigstock DR. Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: Lessons from transgenic animals. J Cell Commun Signal 2010;4:1-4.
31. Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B. Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 2010;62:1523-1532.
32. Ho SC, Lee KY, Chan YF, Kuo LW, Ito K, Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP. Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. J Immunol 2009;183:411-420.
33. Herzog EL, Bucala R. Fibrocytes in health and disease. Exp Hematol 2010;38:548-556.
34. Dendooven A, Gerritsen KG, Nguyen TQ, Kok RJ, Goldschmeding R. Connective tissue growth factor (CTGF/CCN2) ELISA: A novel tool for monitoring fibrosis. Biomarkers 2011;16:289-301.
35. McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight DA, Bai TR. Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2007;292:L278-L286.
36. Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffre V, Galderisi U, De Nardo M, Mastruzzo C, et al. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of MAP kinases. J Cell Biochem 2005;96:858-868.
37. Boyd R, Ratsep MT, Ding LL, Wang HDET. A and ETB receptors are expressed in vascular adventitial fibroblasts. Am J Physiol Heart Circ Physiol 2011;301:H2271-H2278.
38. Wendel M, Petzold A, Koslowski R, Kasper M, Augstein A, Knels L, Bleyl JU, Koch T. Localization of endothelin receptors in bleomycininduced pulmonary fibrosis in the rat. Histochem Cell Biol 2004;122: 507-517.
39. Chrysanthopoulou A, Mitroulis I, Kambas K, Skendros P, Kourtzelis I, Vradelis S, Kolios G, Aslanidis S, Doumas M, Ritis K. Tissue factorthrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A. Arthritis Rheum 2011;63:3586-3597.
40. Balzar S, Chu HW, Silkoff P, Cundall M, Trudeau JB, Strand M, Wenzel S. Increased TGF-beta2 in severe asthma with eosinophilia. J Allergy Clin Immunol 2005;115:110-117.
41. Burgess JK, Johnson PR, Ge Q, Au WW, Poniris MH, McParland BE, King G, Roth M, Black JL. Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 2003;167:71-77.
42. Wang X, Wu G, Gou L, Liu Z, Fan X, Wu L, Liu N. A novel singlechain-fv antibody against connective tissue growth factor attenuates bleomycin-induced pulmonary fibrosis in mice. Respirology 2011;16: 500-507.
43. Nakerakanti SS, Bujor AM, Trojanowska M. CCN2 is required for the TGF-beta induced activation of Smad1-ERK1/2 signaling network. PLoS ONE 2011;6:e21911.
44. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K. Role and interaction of connective tissue growth factor with transforming growth factorbeta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol 1999;181:153-159.
45. Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, et al. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res 2007;313:952-964.
46. Liu S, Shi-wen X, Abraham DJ, Leask A. CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum 2011;63: 239-246.