Involvement of NF kappa B in potentiated effect of Mn-containing dithiocarbamates on MPP+ induced cell death

Cellular and Molecular Neurobiology

Volumn 33, Issue 6, 2013, Pages 815-823

  Williams, Cindi Ann ^a   Lin, Ying ^a   Maynard, Arlene ^a   Cheng, Shu Yuan ^a  

^a JOHN JAY COLLEGE OF CRIMINAL JUSTICE   (United States)

Author keywords

Dithiocarbamates; Mancozeb; Maneb; MPP+; NF B; PC12 cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MANCOZEB; MANEB; SN 50; TRANSCRIPTION FACTOR RELA; DIETHYLDITHIOCARBAMIC ACID; MANGANESE; PEPTIDE; ZINEB;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ASSAY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT; WESTERN BLOTTING; ANIMAL; CELL SURVIVAL; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENETICS; METABOLISM; PARKINSON DISEASE; PATHOLOGY; PC12 CELL LINE; SIGNAL TRANSDUCTION; TOXICITY;

PARKINSONIA;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CELL DEATH; CELL SURVIVAL; DITIOCARB; LUCIFERASES; MANEB; MANGANESE; NF-KAPPA B; PARKINSON DISEASE; PC12 CELLS; PEPTIDES; RATS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; ZINEB;

EID: 84881105431     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-013-9948-1     Document Type: Article

References (64)

1. Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C (2008) The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res 42:849-862
2. Aoki E, Yano R, Yokoyama H, Kato H, Araki T (2009) Role of nuclear transcription factor kappa B (NF-kappa B) for MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine)-induced apoptosis in nigral neurons of mice. Exp Mol Pathol 86:57-64
3. Bachurin SO, Shevtzova EP, Lermontov NN, Serkova TP, Ramsay RR (1996) The effect of dithiocarbamates on neurotoxic action of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) and on mitochondrial respiration chain. Neurotoxicology 17:897-903
4. Baichwal VR, Baeuerle PA (1997) Activate NF-kappa B or die? Curr Biol 7:R94-R96
5. Barlow BK, Lee DW, Cory-Slechta DA, Opanashuk LA (2005) Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology 26:63-75
6. Bowman AB, Kwakye GF, Hernandez EH, Aschner M (2011) Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol 25:191-203
7. Brouillet EP, Shinobu L, McGarvey U, Hochberg F, Beal MF (1993) Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol 120:89-94
8. Cersosimo MG, Koller WC (2006) The diagnosis of manganese-induced Parkinsonism. Neurotoxicology 27:340-346
9. Cicchetti F, Drouin-Ouellet J, Gross RE (2009) Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends Pharmacol Sci 30:475-483
10. 2+ on striatal and nigral synthesis and levels of dopamine and cofactor. Neurotoxicol Teratol 13:483-487
11. Domico LM, Zeevalk GD, Bernard LP, Cooper KR (2006) Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 27:816-825
12. Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28:1079-1091
13. Farina M, Avila DS, da Rocha JB, Aschner M (2013) Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int 62:575-594
14. Ferraz HB, Bertolucci PH, Pereira JS, Lima JG, Andrade LA (1988) Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 38:550-553
15. Florence TM, Stauber JL (1989) Manganese catalysis of dopamine oxidation. Sci Total Environ 78:233-240
16. Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K (2007) Selective inhibition of NF-kappa B activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci USA 104:18754-18759
17. + induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATP-6 and NF-kappaB signaling pathways. J Neuropathol Exp Neurol 62:1144-1153
18. Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Kortsha GX et al (1999) Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease. Neurotoxicology 20:239-247
19. Gueorguiev VD, Cheng SY, Sabban EL (2006) Prolonged activation of cAMP-response element-binding protein and ATP-2 needed for nicotine-triggered elevation tyrosine hydroxylase gene transcription in PC12 cells. J Biol Chem 281:10188-10195
20. Guilarte TR (2010) Manganese and Parkinson's disease: a critical review and new findings. Environ Health Perspect 118:1071-1080
21. Hasegawa E, Takeshige K, Oishi T, Murai Y, Minakami S (1990) 1-Methyl-4-phenylpyridinium (MPP+) induces NADH dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochem Biophys Res Commun 170:1049-1055
22. Hoffman L, Hardej D (2012) Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells. Environ Toxicol Pharmacol 34:556-573
23. Hunot S, Brugg B, Ricard D, Michel PP, Muriel MP, Ruberg M, Faucheux BA, Agid Y, Hirsch EC (1997) Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease. Proc Natl Acad Sci USA 94:7531-7536
24. Kienzl E, Puchinger L, Jellinger K, Linert W, Stachelberger H, Jameson RF (1995) The role of transition metals in the pathogenesis of Parkinson's disease. J Neurol Sci 134(Suppl):69-78
25. Kim Y, Kim JW, Ito K, Lim HS, Cheong HK et al (1999) Idiopathic Parkinsonism with superimposed manganese exposure: utility of positron emission tomography. Neurotoxicology 20:249-252
26. Lezoualch F, Sagara Y, Holsboer F, Behl C (1998) High constitutive NF-kappa B activity mediates resistance to oxidative stress in neuronal cells. J Neurosci 18:3224-3232
27. Lipton SA (1997) Janus faces of NF-kappa B: neurodestruction versus neuroprotection. Nat Med 2:20-22
28. Masqras I, Carrera S, de Verdier PJ, Brennan P, Malid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S (2012) Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem 287:9845-9854
29. Mattson MP, Camandola S (2001) NF-kappa B in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107:247-254
30. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-kappa B protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697
31. Mattson MP, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor kappa B in neuronal survival and plasticity. J Neurochem 74:443-456
32. McCrew DM, Irwin I, Langston JW (2000) Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice. Neurotoxicology 21:309-312
33. Meco G, Bonifati V, Vanacore N, Fabrizio E (1994) Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate) . Scand J Work Environ Health 20:301-305
34. Monte D, Lavasani M, Manning-Bog A (2002) Environmental factors in Parkinson's disease. Neurotoxicology 23:487-502
35. Montgomery EB Jr (1995) Heavy metals and the etiology of Parkinson's disease and other movement disorders. Toxicology 97:3-9
36. Morato GS, Lemos T, Takahashi RN (1989) Acute exposure to maneb alters some behavioral functions in the mouse. Neurotoxicol Teratol 11:421-425
37. Muroyama A, Fujita A, Lv C, Kobayashi S, Fukuyama Y, Mitsumoto Y (2012) Magnolol protects against MPTP/MPP(+)-induced toxicity via inhibition of oxidative stress in vivo models of Parkinson's disease. Parkinsons Dis 2012:985157. doi: 10.1155/2012/985157
38. +) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (ΔΨm) in rat striatum. Exp Neurol 179:103-110
39. Olanow CW (2004) Manganese-induced Parkinsonism and Parkinson's disease. Ann N Y Acad Sci 1012:209-223
40. Panet H, Barzilai A, Daily D, Melamed E, Offen D (2001) Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. J Neurochem 77:391-398
41. Parker WD Jr, Boyson SJ, Parks JK (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723
42. Prohaska JR (1987) Functions of trance elements in brain metabolism. Physiol Rev 67:858-901
43. Ramesh GT, Ghosh D, Gunasekar PG (2002) Activation of early signaling transcription factor, NF-kappaB following low-level manganese exposure. Toxicol Lett 136:151-158
44. Schapira AH (2007) Mitochondrial dysfunction in Parkinson's disease. Cell Death Differ 14:1261-1266
45. Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1:1269
46. Scharf B, Trombetta LD (2007) The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Lon-Evans rats. Toxicol Lett 174:117-124
47. Shen XM, Dryhurst G (1998) Iron- and manganese-catalyzed autoxidation of dopamine in the presence of l-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity. Chem Res Toxicol 11:824-837
48. Soleo L, Defazio G, Scarselli R, Zefferino R, Livrea P, Foa V (1996) Toxicity of fungicides containing ethylene-bis-dithiocarbamate in serumless dissociated mesencephalic-striatal primary coculture. Arch Toxicol 70:678-682
49. Sriram K, Pai KS, Boyd MR, Ravindranath V (1997) Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res 749:44-52
50. Takahashi RN, Rogerio R, Zanin M (1989) Maneb enhances MPTP neurotoxicity in mice. Res Commun Chem Pathol Pharmacol 66:167-170
51. Thiruchelvam M, Brockel BJ, Richfield EK, Baggs RB, Cory-Slechta DA (2000a) Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain Res 873:225-234
52. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA (2000b) The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci 20:9207-9214
53. Tsang MM, Trombetta LD (2007) The protective role of chelators and antioxidants on mancozeb-induced toxicity in rat hippocampal astrocytes. Toxicol Ind Health 23:459-470
54. Tsuboi Y (2012) Environmental-genetic interactions in the pathogenesis of Parkinson's disease. Exp Neurobiol 21:123-128
55. USGS.gov (2009) http://minerals.usgs.gov/minerals/pubs/mcs/2009/mcs2009. pdf
56. Vaccari A, Saba P, Mocci I, Ruiu S (1999) Dithiocarbamate pesticides affect glutamate transport in brain synaptic vesicles. J Pharmacol Exp Ther 228:1-5
57. van der Mark M, Brouwer M, Kromhout H, Nijssen P, Huss A, Vermeulen R (2012) Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results. Environ Health Perspect 120:340-347
58. Walters TL, Irwin I, Delfani K, Langston JW, Janson AM (1999) Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Exp Neurol 156:62-70
59. Xu X, Gao W, Dou S, Cheng B (2013) Simvastatin inhibited the apoptosis of PC12 cells induced by 1-methyl-4-phenylpyridinium ion via inhibiting reactive oxygen species production. Cell Mol Neurobiol 33:69-73
60. 2+ signaling and caspase-3 activity in neuronal PC12 cells. Cell Mol Neurobiol 33:205-212
61. Zhang J, Fitsanakis VA, Gu G, Jing D, Ao M, Amarnath V, Montine TJ (2003) Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction. J Neurochem 84:336-346
62. Zhang J, Cao R, Cai T, Aschner M, Zhao F, Yao T, Chen Y, Cao Z, Luo W, Chen J (2013) The role of autophagy dysregulation in manganese-induced dopaminergic neurodegeneration. Neurotox Res. doi: 10.1007/s12640-013-9392-5
63. Zhao F, Zhang JB, Cai TJ, Liu XQ, Liu MC, Ke T, Chen JY, Luo WJ (2012) Manganese induces p21 expression in PC12 cells at the transcriptional level. Neuroscience 215:184-195
64. Zhou Y, Shie FS, Piccardo P, MOntine TJ, Zhang J (2004) Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease. Neuroscience 128:281-291