Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia

Acta Neuropathologica

Volumn 126, Issue 2, 2013, Pages 219-235

  Finardi, Adele ^a   Colciaghi, Francesca ^a   Castana, Laura ^b   Locatelli, Denise ^a   Marras, Carlo Efisio ^a,d   Nobili, Paola ^a   Fratelli, Maddalena ^c   Bramerio, Manuela Adele ^b   Lorusso, Giorgio ^b   Battaglia, Giorgio Stefano ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b OSPEDALE NIGUARDA CA GRANDA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Dysmorphic neurons; Glutamatergic synaptic input; MAGUK proteins; Malformations of cortical development; NMDA receptor; Seizure induced plasticity

Indexed keywords

AMPA RECEPTOR; ANTICONVULSIVE AGENT; GUANYLATE KINASE; MEMBRANE ASSOCIATED GUANYLATE KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ADOLESCENT; ADULT; ARTICLE; CELL DEATH; CELL DENSITY; CELL POLARITY; CELL SIZE; CELL STRUCTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL DYSPLASIA; DISEASE DURATION; EPILEPSY; EPILEPTIC DISCHARGE; FEMALE; GLIA CELL; GLIOSIS; HUMAN; HUMAN CELL; INFANT; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; SCHOOL CHILD; SYNAPSE; UPREGULATION; WHITE MATTER;

ADOLESCENT; ADULT; BRAIN DISEASES; CELL SIZE; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; GLIOSIS; GLUTAMIC ACID; HUMANS; INFANT; MALE; MALFORMATIONS OF CORTICAL DEVELOPMENT; MIDDLE AGED; NEURONAL PLASTICITY; NEURONS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; YOUNG ADULT;

EID: 84881103293     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1143-4     Document Type: Article

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