Induced expression of NMDAR2 proteins and differential expression of NMDAR1 splice variants in dysplastic neurons of human epileptic neocortex

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 1, 1998, Pages 47-62

  Ying, Zhong ^a   Babb, Thomas L ^a   Comair, Youssef G ^a   Bingaman, William ^a   Bushey, Michael ^a   Touhalisky, Kathy ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cortical dysplasias; Epilepsy; GluR2 3; Glutamate receptors; Hippocampal sclerosis; Immunocytochemistry; Nmda subunits

Indexed keywords

GLUTAMATE RECEPTOR;

ARTICLE; DYSPLASIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACTABLE EPILEPSY; NEOCORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; ALTERNATIVE SPLICING; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMANS; MIDDLE AGED; NEOCORTEX; NEURONS; PARIETAL LOBE; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; TEMPORAL LOBE; VARIATION (GENETICS);

EID: 0031974822     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/00005072-199801000-00007     Document Type: Article

References (34)

1. Taylor DC, Falconer MA, Bruton C J, Corsellis JAN. Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 1971;34:369-87
2. Mischel PS. Nguyen LP. Vinters HV. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J Neuropathol Exp Neurol 1995;54:137-53
3. Fonnum F. Glutamate: A neurotransmitter in mammalian brain. J Neurochcm 1984;42:1-11
4. Cotman CW, Monaghan DT. Ottersen OP, Storm-Mathisen J. Anatomical organization of excitatory amino acid receptors and their pathways. Trends in Neurosci 1987;10:273-79
5. Garcia-Ladona FJ, Palacios JM, Probst A, Wieser HG, Mengod G. Excitatory amino acid AMPA receptor mRNA localizaton in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study. Mol Brain Res 1994; 21:75-84
6. Babb TL, Mathern GW, Leite JP. Pretorius JK, Yeoman KM, Kuhl-man PA. Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy. Epilepsy Research 1996;26: 193-205
7. Mathern GW, Leite JP, Babb, et al. Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining. NeuroReport 1996;7:1029-35
8. Lynd-Balta E, Pilcher WH, Joseph SA. Distribution of AMPA receptor subunits in the hippocampal formation of temporal lobe epilepsy patients. Neuroscience 1996;72:15-29
9. Watkins JC, Evans RH. Excitatory amino acid transmitters. Ann Rev Pharmcol Toxicol 1981;21:65-204
10. Monaghan DT. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxico 1989;29:365-402
11. Fagg GE, Massieu L. Excitatory amino acid-receptor subtypes. In: Meldrum BS, ed. Excitatory amino acid antagonists. Oxford: Blackwell Scientific Publications, 1991: 39-63
12. Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 1994:17:31-108
13. Nakanishi S, Masu M. Molecular diversity and functions of glutamate receptors. Annu Rev Biophy Biomol Struct 1994:23:319-48
14. Morris III HH. Summary of epilepsy surgery protocols. In: Lüders, ed. Epilepsy surgery. New York: Raven, 1992:786-88
15. Babb TL, Pretorius JK, Davenport C, Leib JP, Crandall PH. Temporal lobe volumetric cell densities in temporal lobe epilepsy. Epilepsia 1984;25:729-40
16. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 1991;42:351-63
17. Wenthold RJ, Yokotani N, Doi K, Keiji W. Immunocytochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. J Biol Chem 1992:267:501-7
18. Siegel SJ, Brose N, Janssen WG. Gasic CP, Jahn R, Heinemann SF. Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sei USA 1994; 91:564-68
19. Petralia RS, Yokotani N, Wenthold RJ. Light and electron microscope distribution of the NMDA receptor subunit NR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci 1994, a;14:667-96
20. Petralia RS, Wang YX, Wenthold RJ. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J Neurosci 1994, b; 14:6102-20
21. Johnson RR, Jiang X, Burkhalter A. Regional and laminar differences in synaptic localization of NMDA receptor subunit NR1 splice variants in rat visual cortex and hippocampus. J Comp Neurol 1996;368:335-55
22. Babb TL, Pretorius JK, Kupfer WR, Crandall PH. Glutamate-decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. J Neurosci 1989; 9:2562-74
23. Mathern GM, Babb TL, Pretorius JK, Leite JP. Reactive synapto-genesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 1995;15:3990-4004
24. Bailey P. Von Bonin G. The isocortex of man. Urbana: University of Illinois Press. 1951
25. Emery J., Anderson K, Rojiani AM. Significance of ectopic neurons in normal white matter: A morphometric study. J Neuropath Exp Neurol 1994:54:470
26. Steward O, Reeves TM. Protein synthetic machinery beneath postsynaptic sites on CNS neurons: Association between polyribosomes and other organelles at the synaptic site. J Neurosci 1988;8:176-84
27. Gazzaley AH, Benson D, Huntley GW, Morrison JH. Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentata gyrus granule cells after perforant path transection. J Neurosci 1997;17:2006-17
28. Ikeda K, Nagasawa M, Mori H, et al. Cloning and expression of the e4 subunit of the NMDA receptor channel. FEBS Lett 1992; 313:34-38
29. Kutsuwada T, Kashiwabuchi N, Mori H, et al. Molecular diversity of the NMDA receptor channel. Nature 1992;358:36-41
30. Meguro H, Mori H, Araki K, et al. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 1992; 357:70-74
31. Monyer H. Sprengel R, Schoepfer R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992;256:1217-27
32. Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature 1991;354:31-37
33. Sugihara H. Moriyoshi K, Ishii Y, Masu M, Nakanishi S. Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem Biophys Res Commun 1992;185: 826-32
34. Hollman MJ, Boulter C, Maron L. Beasley J, Sullivan G, Heine-mann S. Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 1993:10:943-54