LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

Blood

Volumn 121, Issue 23, 2013, Pages 4672-4683

  Krzewski, Konrad ^a   Gil Krzewska, Aleksandra ^a   Nguyen, Victoria ^a   Peruzzi, Giovanna ^a   Coligan, John E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADAPTOR PROTEIN; ADAPTOR PROTEIN 1; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GRANZYME B; INTERLEUKIN 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PERFORIN; UNCLASSIFIED DRUG; GRANZYME; LAMP1 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL FRACTIONATION; CELL GRANULE; CELL LYSATE; CELL MEDIATED CYTOTOXICITY; CELL MOTION; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; EX VIVO STUDY; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOLOGICAL SYNAPSE; LYSOSOME; MICROTUBULE ORGANIZING CENTER; NATURAL KILLER CELL; PRIORITY JOURNAL; RNA INTERFERENCE; TARGET CELL; TIME LAPSE IMAGING; TRANS GOLGI NETWORK; TRANSPORT VESICLE; APOPTOSIS; CELL CULTURE; CELL MEMBRANE; CELL PROLIFERATION; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; KIDNEY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL MEMBRANE; CELL PROLIFERATION; CELLS, CULTURED; CYTOPLASMIC GRANULES; FLOW CYTOMETRY; GRANZYMES; HUMANS; KIDNEY; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; PERFORIN; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR AP-1;

MLCS; MLOWN;

EID: 84881065930     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-08-453738     Document Type: Article

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