VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells

European Journal of Immunology

Volumn 41, Issue 11, 2011, Pages 3323-3329

  Krzewski, Konrad ^a,b   Gil Krzewska, Aleksandra ^a   Watts, James ^a   Stern, Joel N H ^a   Strominger, Jack L ^a  

^a HARVARD UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Immunological synapse; Lytic granules; Perforin; Vesicle fusion

Indexed keywords

GAMMA INTERFERON; PERFORIN; SYNAPTOBREVIN; UNCLASSIFIED DRUG; VAMP4 PROTEIN; VAMP7 PROTEIN;

ARTICLE; CELL GRANULE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DEGRANULATION; EXOCYTOSIS; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TUMOR CELL LINE;

BLOTTING, WESTERN; CELL DEGRANULATION; CELL LINE; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; EXOCYTOSIS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICROSCOPY, CONFOCAL; R-SNARE PROTEINS; SECRETORY VESICLES;

EID: 80054895698     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141582     Document Type: Article

References (27)

1. Orange, J. S. and Ballas, Z. K., Natural killer cells in human health and disease. Clin. Immunol. 2006. 118: 1-10.
2. Vivier, E., Tomasello, E., Baratin, M., Walzer, T. and Ugolini, S., Functions of natural killer cells. Nat. Immunol. 2008. 9: 503-510.
3. Bryceson, Y. T. and Long, E. O., Line of attack: NK cell specificity and integration of signals. Curr. Opin. Immunol. 2008. 20: 344-352.
4. Lanier, L. L., Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 2008. 9: 495-502.
5. Davis, D. M., Chiu, I., Fassett, M., Cohen, G. B., Mandelboim, O. and Strominger, J. L., The human natural killer cell immune synapse. Proc. Natl. Acad. Sci. USA 1999. 96: 15062-15067.
6. Monks, C. R., Freiberg, B. A., Kupfer, H., Sciaky, N. and Kupfer, A., Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998. 395: 82-86.
7. Kim, H., Suh, J. M., Hwang, E. S., Kim, D. W., Chung, H. K., Song, J. H., Hwang, J. H. et al., Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling. J. Immunol. 2003. 171: 616-627.
8. Krzewski, K. and Strominger, J. L., The killer's kiss: the many functions of NK cell immunological synapses. Curr. Opin. Cell Biol. 2008. 20: 597-605.
9. Orange, J. S., Formation and function of the lytic NK-cell immunological synapse. Nat. Rev. Immunol. 2008. 8: 713-725.
10. Jahn, R. and Scheller, R. H., SNAREs - engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 2006. 7: 631-643.
11. Stow, J. L., Manderson, A. P. and Murray, R. Z., SNAREing immunity: the role of SNAREs in the immune system. Nat. Rev. Immunol. 2006. 6: 919-929.
12. Südhof, T. C. and Rothman, J. E., Membrane fusion: grappling with SNARE and SM proteins. Science 2009. 323: 474-477.
13. Marcet-Palacios, M., Odemuyiwa, S. O., Coughlin, J. J., Garofoli, D., Ewen, C., Davidson, C. E., Ghaffari, M. et al., Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochem. Biophys. Res. Commun. 2008. 366: 617-623.
14. Casey, T. M., Meade, J. L. and Hewitt, E. W., Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome. Mol. Cell Proteomics 2007. 6: 767-780.
15. Eaton, B. A., Haugwitz, M., Lau, D. and Moore, H. P., Biogenesis of regulated exocytotic carriers in neuroendocrine cells. J. Neurosci. 2000. 20: 7334-7344.
16. Fujita-Yoshigaki, J., Katsumata, O., Matsuki, M., Yoshigaki, T., Furuyama, S. and Sugiya, H., Difference in distribution of membrane proteins between low- and high-density secretory granules in parotid acinar cells. Biochem. Biophys. Res. Commun. 2006. 344: 283-292.
17. Steegmaier, M., Klumperman, J., Foletti, D. L., Yoo, J. S. and Scheller, R. H., Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Mol. Biol. Cell 1999. 10: 1957-1972.
18. Das, V., Nal, B., Dujeancourt, A., Thoulouze, M.-I., Galli, T., Roux, P., Dautry-Varsat, A. et al., Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity 2004. 20: 577-588.
19. Loo, L. S., Hwang, L. A., Ong, Y. M., Tay, H. S., Wang, C. C. and Hong, W., A role for endobrevin/VAMP8 in CTL lytic granule exocytosis. Eur. J. Immunol. 2009. 39: 3520-3528.
20. Sander, L. E., Frank, S. P., Bolat, S., Blank, U., Galli, T., Bigalke, H., Bischoff, S. C. et al., Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur. J. Immunol. 2008. 38: 855-863.
21. Okayama, M., Arakawa, T., Tanimura, A., Mizoguchi, I., Tajima, Y. and Takuma, T., Role of VAMP8/endobrevin in constitutive exocytotic pathway in HeLa cells. Cell Struct. Funct. 2009. 34: 115-125.
22. Cocucci, E., Racchetti, G., Rupnik, M. and Meldolesi, J., The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4. J. Cell Sci. 2008. 121: 2983-2991.
23. Logan, M. R., Lacy, P., Odemuyiwa, S. O., Steward, M., Davoine, F., Kita, H. and Moqbel, R., A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy 2006. 61: 777-784.
24. Braun, V., Fraisier, V., Raposo, G., Hurbain, I., Sibarita, J.-B., Chavrier, P., Galli, T. et al., TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J. 2004. 23: 4166-4176.
25. Krzewski, K., Chen, X. and Strominger, J. L., WIP is essential for lytic granule polarization and NK cell cytotoxicity. Proc. Natl. Acad. Sci. USA 2008. 105: 2568-2573.
26. Kankaanpää, P., Pahajoki, K., Marjomäki, V., Heino, J. and White, D., BioImageXD - new open source free software for the processing, analysis and visualization of multidimensional microscopic images. Microsc. Today 2006. 14: 12-16.
27. Manders, E. M., Stap, J., Brakenhoff, G. J., van Driel, R. and Aten, J. A., Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy. J. Cell Sci. 1992. 103: 857-862.