Hypermethylation and low transcription of TLR2 gene in chronic periodontitis

Human Immunology

Volumn 74, Issue 9, 2013, Pages 1231-1236

  de Faria Amormino, Simone Angélica ^a   Arão, Telma Cristina ^a   Saraiva, Adriana Machado ^a   Gomez, Ricardo Santiago ^a   Dutra, Walderez Ornelas ^a   da Costa, José Eustáquio ^a   de Fátima Correia Silva, Jeane ^a   Moreira, Paula Rocha ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 2;

ADULT; ARTICLE; CHRONIC PERIODONTITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC TRANSCRIPTION; GINGIVA; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; CHRONIC PERIODONTITIS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GINGIVA; HUMANS; MALE; MIDDLE AGED; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC;

EID: 84880928399     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.04.037     Document Type: Article

References (44)

1. Kinane D.F., Hart T.C. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 2003, 14:430-449.
2. Ishikawa I. Host responses in periodontal disease: a preview. Periodontology 2007, 2000(43):9-13.
3. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001, 2:675-680.
4. Zhang P., Liu J., Xu Q., et al. TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-κB. J Biol Chem 2011, 286:24159-24169.
5. Kocgozlu L., Elkaim R., Tenenbaum H., Werner S. Variable cell responses to P. gingivalis lipopolysaccharide. J Dent Res 2009, 88:741-745.
6. Teng Y.T. Protective and destructive immunity in the periodontium: Part I - Innate and humoral immunity and the periodontium. J Dent Res 2006, 85:198-208.
7. Burns E., Bachrach G., Shapira L., Nussbaum G. TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol 2006, 177:8296-8300.
8. Harokopakis E., Hajishengallis G. Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol 2005, 35:1201-1210.
9. Mahanonda R., Pichyangkul S. Toll-like receptors and their role in periodontal health and disease. Periodontology 2007, 2000(43):41-55.
10. Uehara A., Takada H. Functional TLRs and NODs in human gingival fibroblasts. J Dent Res 2007, 86:249-254.
11. Beklen A., Sorsa T., Konttinen Y.T. Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17. Oral Microbiol Immunol 2009, 24:38-42.
12. Kajita K., Honda T., Amanuma R., et al. Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. Oral Microbiol Immunol 2007, 22:398-402.
13. Haehnel V., Schwarzfischer L., Fenton M.J., Rehli M. Transcriptional regulation of the human Toll-like receptor 2 gene in monocytes and macrophages. J Immunol 2002, 168:5629-5637.
14. Dutra W.O., Moreira P.R., Souza P.E., et al. Implications of cytokine gene polymorphisms on the orchestration of the immune response: lessons learned from oral disease. Cytokine Growth Factor Rev 2009, 20:223-232.
15. Lima P.M., Souza P.E., Costa J.E., et al. Aggressive and chronic periodontitis correlate with distinct cellular sources of key immunoregulatory cytokines. J Periodontol 2011, 82:86-95.
16. Gomez R.S., Dutra W.O., Moreira P.R. Epigenetics and periodontal disease: future perspectives. Inflamm Res 2009, 58:625-629.
17. Wilson A.G. Epigenetic regulation in the inflammatory response and relevance to common diseases. J Periodontol 2008, 79:1514-1519.
18. Baylin S.B. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2005, 2:4-11.
19. Esteller M., Herman J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002, 196:1-7.
20. Johnson I.T., Belshaw N.J. Environment, diet and CpG island methylation: epigenetic signals in gastrointestinal neoplasia. Food Chem Toxicol 2008, 46:1346-1359.
21. Gopisetty G., Ramachandran K., Singal R. DNA methylation and apoptosis. Mol Immunol 2006, 43:1729-1740.
22. Shuto T., Furuta T., Oba M., et al. Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J 2006, 20:782-784.
23. Furuta T., Shuto T., Shimasaki S., et al. DNA demethylation- dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription. BMC Mol Biol 2008, 9:39.
24. Barros S.P., Offenbacher S. Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 2009, 88:400-408.
25. Armitage G.C. International workshop for a classification of periodontal diseases and conditions. Ann Periodontol 1999, 4:1-112.
26. Livak K.J., Schimittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCt method. Methods 2001, 25:402-408.
27. Feinberg A.P. Epigenetics at the epicenter of modern medicine. JAMA 2008, 299:1345-1350.
28. Offenbacher S., Barros S.P., Beck J.D. Rethinking periodontal inflammation. J Periodontol 2008, 79:1577-1584.
29. Richardson B. DNA methylation and auto immune disease. Clin Immunol 2003, 109:72-79.
30. Loo W.T., Jin L., Cheung M.N., et al. Epigenetic change in E-cadherin and Cox-2 to predict chronic periodontitis. J Trans Med 2010, 4(8):110.
31. Zhang S., Barros S.P., Niculescu M.D., et al. Alteration of PTGS2 promoter methylation in chronic periodontitis. J Dent Res 2010, 89:133-137.
32. Viana M.B., Cardoso F.P., Diniz M.G., et al. Methylation pattern of IFN-γ and IL-10 genes in periodontal tissues. Immunobiology 2011, 216:936-941.
33. Oliveira N.F., Damm G.R., Andia D.C., et al. DNA methylation status of the IL8 gene promoter in oral cells of smokers and non-smokers with chronic periodontitis. J Clin Periodontol 2009, 36:719-725.
34. Andia D.C., Oliveira N.F., Casarin R.C., et al. DNA methylation status of the IL8 gene promoter in aggressive periodontitis. J Periodontol 2010, 81:1336-1341.
35. Zhang S., Crivello A., Offenbacher S., et al. Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis. J Clin Periodontol 2010, 37:953-961.
36. Ishida K., Kobayashi T., Ito S., et al. Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. J Periodontol 2012, 83:917-925.
37. Yin L., Chung W.O. Epigenetic regulation of human β-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteria. Mucosal Immunol 2011, 4:409-419.
38. Oliveira N.F., Andia D.C., Planello A.C., et al. TLR2 and TLR4 gene promoter methylation status during chronic periodontitis. J Clin Periodontol 2011, 38:975-983.
39. Valinluck V., Wu W., Liu P., et al. Impact of cytosine 5-halogens on the interaction of DNA with restriction endonucleases and methyltransferase. Chem Res Toxicol 2006, 19:556-562.
40. Valinluck V., Sowers L.C. Inflammation mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. Cancer Res 2007, 67:5583-5586.
41. Kominsky D.J., Keely S., MacManus C.F., et al. An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol 2011, 186:6505-6514.
42. American Academy of Periodontology Diagnosis of periodontal disease - position paper. J Periodontol 2003, 74:1237-1247.
43. Johnson C.M., Tapping R.I. Microbial products stimulate human Toll-like receptor 2 expressions through histone modification surrounding a proximal NF-kappaB-binding site. J Biol Chem 2007, 282:31197-31205.
44. Barnes P.J., Karin M. NF-κb a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336:1066-1071.