DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription

BMC Molecular Biology

Volumn 9, Issue 1, 2008, Pages

  Furuta, Takashi ^a   Shuto, Tsuyoshi ^a   Shimasaki, Shogo ^a   Ohira, Yuko ^a   Suico, Mary Ann ^a   Gruenert, Dieter C ^b,c,d   Kai, Hirofumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; MITHRAMYCIN; MITHRAMYCIN A; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL ACTIVATION; CONTROLLED STUDY; CPG ISLAND; CYSTIC FIBROSIS; DNA DEMETHYLATION; DNA METHYLATION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENETIC ENHANCEMENT; GENETIC TRANSCRIPTION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MRNA EXPRESSION LEVEL; PROMOTER REGION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TLR2 GENE; BIOLOGICAL MODEL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PROTEIN BINDING;

BINDING SITES; CELL LINE; CPG ISLANDS; CYSTIC FIBROSIS; DNA METHYLATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SP1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC;

EID: 47149118525     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-9-39     Document Type: Article

References (42)

1. Aderem A, Ulevitch RJ: Toll-like receptors in the induction of the innate immune response. Nature 2000, 406(6797):782-787.
2. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004, 4(7):499-511.
3. Kopp E, Medzhitov R: Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003, 15(4):396-401.
4. Kirschning CJ, Schumann RR: TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr Top Microbiol Immunol 2002, 270:121-144.
5. Beutler B: TLR4 as the mammalian endotoxin sensor. Curr Top Microbiol Immunol 2002, 270:109-120.
6. Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD: Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative crosstalk with p38 MAP kinase. J Biol Chem 2002, 277(19):17263-17270.
7. Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD: Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem 2002, 277(49):47444-47450.
8. Hermoso MA, Matsuguchi T, Smoak K, Cidlowski JA: Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression. Mol Cell Biol 2004, 24(11):4743-4756.
9. Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB: Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 2004, 50(12):3856-3865.
10. Harter L, Mica L, Stocker R, Trentz O, Keel M: Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis. Shock 2004, 22(5):403-409.
11. Canto E, Ricart E, Monfort D, Gonzalez-Juan D, Balanzo J, Rodriguez-Sanchez JL, Vidal S: TNF alpha production to TLR2 ligands in active IBD patients. Clin Immunol 2006, 119(2):156-165.
12. Arranz A, Abad C, Juarranz Y, Torroba M, Rosignoli F, Leceta J, Gomariz RP, Martinez C: Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis. Ann N Y Acad Sci 2006, 1070:129-134.
13. Pier GB: CFTR mutations and host susceptibility to Pseu-domonas aeruginosa lung infection. Curr Opin Microbiol 2002, 5(1):81-86.
14. Ratjen F, Doring G: Cystic fibrosis. Lancet 2003, 361(9358):681-689.
15. Muir A, Soong G, Sokol S, Reddy B, Gomez MI, Van Heeckeren A, Prince A: Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol 2004, 30(6):777-783.
16. Firoved AM, Ornatowski W, Deretic V: Microarray analysis reveals induction of lipoprotein genes in mucoid Pseu-domonas aeruginosa: implications for inflammation in cystic fibrosis. Infect Immun 2004, 72(9):5012-5018.
17. Shuto T, Furuta T, Oba M, Xu H, Li JD, Cheung J, Gruenert DC, Uehara A, Suico MA, Okiyoneda T, Kai H: Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. Faseb J 2006, 20(6):782-784.
18. Koga T, Suico MA, Nakamura H, Taura M, Lu Z, Shuto T, Okiyoneda T, Kai H: Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. FEBS Lett 2005, 579(13):2811-2816.
19. Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, Li JD: Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-depend-ent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci USA 2001, 98(15):8774-8779.
20. Cheng JC, Yoo CB, Weisenberger DJ, Chuang J, Wozniak C, Liang G, Marquez VE, Greer S, Orntoft TF, Thykjaer T, et al.: Preferential response of cancer cells to zebularine. Cancer Cell 2004, 6(2):151-158.
21. Issa JP: CpG island methylator phenotype in cancer. Nat Rev Cancer 2004, 4(12):988-993.
22. Zhu WG, Srinivasan K, Dai Z, Duan W, Druhan LJ, Ding H, Yee L, Vil-lalona-Calero MA, Plass C, Otterson GA: Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter. Mol Cell Biol 2003, 23(12):4056-4065.
23. Alikhani-Koopaei R, Fouladkou F, Frey FJ, Frey BM: Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest 2004, 114(8):1146-1157.
24. Stirzaker C, Song JZ, Davidson B, Clark SJ: Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res 2004, 64(11):3871-3877.
25. Honda H, Pazin MJ, Ji H, Wernyj RP, Morin PJ: Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J Biol Chem 2006, 281(30):21433-21444.
26. Kransdorf EP, Wang SZ, Zhu SZ, Langston TB, Rupon JW, Ginder GD: MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood 2006, 108(8):2836-2845.
27. Patra SK, Patra A, Zhao H, Dahiya R: DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 2002, 33(3):163-171.
28. Brenner C, Fuks F: DNA methyltransferases: facts, clues, mysteries. Curr Top Microbiol Immunol 2006, 301:45-66.
29. Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F, Niehrs C: Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007, 445(7128):671-675.
30. Kelley TJ, Elmer HL: In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium. J Clin Invest 2000, 106(3):403-410.
31. Xu W, Zheng S, Goggans TM, Kiser P, Quinones-Mateu ME, Janocha AJ, Comhair SA, Slee R, Williams BR, Erzurum SC: Cystic fibrosis and normal human airway epithelial cell response to influenza a viral infection. J Interferon Cytokine Res 2006, 26(9):609-627.
32. Henke MO, Renner A, Rubin BK, Gyves JI, Lorenz E, Koo JS: Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharide. Exp Lung Res 2006, 32(8):331-347.
33. Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA: Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. J Immunol 2006, 177(8):5186-5194.
34. Tabary O, Zahm JM, Hinnrasky J, Couetil JP, Cornillet P, Guenounou M, Gaillard D, Puchelle E, Jacquot J: Selective up-regulation of chemokine IL-8 expression in cystic fibrosis bronchial gland cells in vivo and in vitro. Am J Pathol 1998, 153(3):921-930.
35. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, Fink-beiner WE, Widdicombe JH, Gruenert DC: CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 1994, 10(1):38-47.
36. Bruscia E, Sangiuolo F, Sinibaldi P, Goncz KK, Novelli G, Gruenert DC: Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting. Gene therapy 2002, 9(11):683-685.
37. Kunzelmann K, Schwiebert EM, Zeitlin PL, Kuo WL, Stanton BA, Gruenert DC: An immortalized cystic fibrosis tracheal epithelial cell line homozygous for the delta F508 CFTR mutation. Am J Respir Cell Mol Biol 1993, 8(5):522-529.
38. Okiyoneda T, Wada I, Jono H, Shuto T, Yoshitake K, Nakano N, Nagayama S, Harada K, Isohama Y, Miyata T, Kai H: Calnexin Delta 185-520 partially reverses the misprocessing of the Delta F508 cystic fibrosis transmembrane conductance regulator. FEBS Lett 2002, 526(1–3):87-92.
39. Schoumacher RA, Ram J, Iannuzzi MC, Bradbury NA, Wallace RW, Hon CT, Kelly DR, Schmid SM, Gelder FB, Rado TA, RA Frizzell: A cystic fibrosis pancreatic adenocarcinoma cell line. Proc Natl Acad Sci USA 1990, 87(10):4012-4016.
40. Seki Y, Suico MA, Uto A, Hisatsune A, Shuto T, Isohama Y, Kai H: The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome. Cancer Res 2002, 62(22):6579-6586.
41. Suico MA, Koga T, Shuto T, Hisatsune A, Lu Z, Basbaum C, Okiyoneda T, Kai H: Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells. Biochem Biophys Res Commun 2004, 324(4):1302-1308.
42. Shuto T, Furuta T, Cheung J, Gruenert DC, Ohira Y, Shimasaki S, Suico MA, Sato K, Kai H: Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells. Leuk Res 2007, 31:1721-8.