Functional TLRs and NODs in human gingival fibroblasts

Journal of Dental Research

Volumn 86, Issue 3, 2007, Pages 249-254

  Uehara, A ^a   Takada, H ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Fibroblasts; Innate immunity; NOD1; NOD2; TLR

Indexed keywords

AUTACOID; BACTERIAL PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LY96 PROTEIN, HUMAN; MESSENGER RNA; MYD88 PROTEIN, HUMAN; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE OLIGOMERIZATION DOMAIN PROTEIN; PROTEIN MD 2; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHILD; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; FLOW CYTOMETRY; GINGIVA; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

BACTERIAL PROTEINS; CELLS, CULTURED; CHILD; CYTOKINES; FIBROBLASTS; FLOW CYTOMETRY; GINGIVA; HUMANS; IMMUNITY, NATURAL; INFLAMMATION MEDIATORS; LYMPHOCYTE ANTIGEN 96; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; NOD SIGNALING ADAPTOR PROTEINS; POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTORS;

EID: 33947356654     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910708600310     Document Type: Article

References (23)

1. Akira S, Uematsu S, Takeuchi O (2006). Pathogen recognition and innate immunity. Cell 124:783-801.
2. Asai Y, Ohyama Y, Gen K, Ogawa T (2001). Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect Immun 69:7387-7395.
3. Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M (2001). Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 22:199-204.
4. Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, et al. (2003). An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4:702-707.
5. Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J, et al. (2003a). Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science 300:1584-1587.
6. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, et al. (2003b). Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278:8869-8872.
7. Hatakeyama J, Tamai R, Sugiyama A, Akashi S, Sugawara S, Takada H (2003). Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell-surface components through the CD14/Toll-like receptor system. Oral Microbiol Immunol 18:14-23.
8. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, et al. (1999). Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem 274:14560-14567.
9. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, et al. (2003). Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278:5509-5512.
10. Kusumoto Y, Hirano H, Saitoh K, Yamada S, Takedachi M, Nozaki T, et al. (2004). Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via Toll-like receptor 2. J Periodontal 75:370-379.
11. Mizushima S, Nagata S (1990). pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res 18:5322.
12. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Núñez G (2001). Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-4818.
13. Okusawa T, Fujita M, Nakamura J, Into T, Yasuda M, Yoshimura A, et al. (2004). Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by Toll-like receptors 2 and 6. Infect Immun 72:1657-1665.
14. Sugawara S, Sugiyama A, Nemoto E, Rikiishi H, Takada H (1998). Heterogeneous expression and release of CD14 by human gingival fibroblasts: characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharide. Infect Immun 66:3043-3049.
15. Sugawara Y, Uehara A, Fujimoto Y, Kusumoto S, Fukase K, Shibata K, et al. (2006). Toll-like receptors, NOD1 and NOD2, in oral epithelial cells. J Dent Res 85:524-529.
16. Takada H, Mihara J, Morisaki I, Hamada S (1991). Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immun 59:295-301.
17. + fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression. Infect Immun 70:1272-1278.
18. Tamura M, Tokuda M, Nagaoka S, Takada H (1992). Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures. Infect Immun 60:4932-4937.
19. Uehara A, Sugawara S, Tamai R, Takada H (2001). Contrasting responses of human gingival and colonic epithelial cells to lipopolysaccharides, lipoteichoic acids and peptidoglycans in the presence of soluble CD14. Med Microbiol Immunol (Berl) 189:185-192.
20. Uehara A, Muramoto K, Imamura T, Nakayama K, Potempa J, Travis J, et al. (2005a). Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture. J Immunol 175:6076-6084.
21. Uehara A, Sugawara Y, Kurata S, Fujimoto Y, Fukase K, Kusumoto S, et al. (2005b). Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via Toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Cell Microbiol 7:675-686.
22. Wang PL, Ohura K, Fujii T, Oido-Mori M, Kowashi Y, Kikuchi M, et al. (2003). DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues. Biochem Biophys Res Commun 305:970-973.
23. Yasumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K (1992). Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-κB-like binding sites of the interleukin 8 gene. J Biol Chem 267:22506-22511.