Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis

Journal of Clinical Periodontology

Volumn 37, Issue 11, 2010, Pages 953-961

  Zhang, Shaoping ^a   Crivello, Antonino ^b   Offenbacher, Steven ^a,b   Moretti, Antonio ^b   Paquette, David W ^b   Barros, Silvana P ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

DNA methylation; gene expression; interferon gamma; periodontal disease; pyrosequencing

Indexed keywords

GAMMA INTERFERON;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; CPG ISLAND; DNA METHYLATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; GINGIVITIS; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; CPG ISLANDS; DNA METHYLATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GINGIVITIS; HUMANS; INTERFERON-GAMMA; LINEAR MODELS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; YOUNG ADULT;

EID: 78449262709     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2010.01616.x     Document Type: Article

References (45)

1. Aramaki, M., Nagasawa, T., Koseki, T., &, Ishikawa, I., (1998) Presence of activated B-1 cells in chronic inflamed gingival tissue. Journal of Clinical Immunology 18, 421 - 429.
2. Barros, S. P., &, Offenbacher, S., (2009) Epigenetics: connecting environment and genotype to phenotype and disease. Journal of Dental Research 88, 400 - 408.
3. Berenson, L. S., Ota, N., &, Murphy, K. M., (2004) Issues in T-helper 1 development-resolved and unresolved. Immunological Reviews 202, 157 - 174.
4. Bird, A. P., &, Wolffe, A. P., (1999) Methylation-induced repression-belts, braces, and chromatin. Cell 99, 451 - 454.
5. Bird, A., (2002) DNA methylation patterns and epigenetic memory. Genes and Development 16, 6 - 21.
6. Boehm, U., Klamp, T., Groot, M., &, Howard, J. C., (1997) Cellular responses to interferon-gamma. Annual Review of Immunology 15, 749 - 795.
7. Bream, J. H., Ping, A., Zhang, X., Winkler, C., &, Young, H. A., (2002) A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription. Genes and Immunity 3, 165 - 169.
8. Cardoso, F. P., Viana, M. B., Sobrinho, A. P., Diniz, M. G., Brito, J. A., Gomes, C. C., Moreira, P. R., &, Gomez, R. S., (2010) Methylation pattern of the IFN-gamma gene in human dental pulp. Journal of Endodontics 36, 642 - 646.
9. Colella, S., Shen, L., Baggerly, K. A., Issa, J. P., &, Krahe, R., (2003) Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. BioTechniques 35, 146 - 150.
10. Dutzan, N., Vernal, R., Hernandez, M., Dezerega, A., Rivera, O., Silva, N., Aguillon, J. C., Puente, J., Pozo, P., &, Gamonal, J., (2009) Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis. Journal of Periodontology 80, 290 - 296.
11. Farrar, M. A., &, Schreiber, R. D., (1993) The molecular cell biology of interferon-gamma and its receptor. Annual Review of Immunology 11, 571 - 611.
12. Fujihashi, K., Yamamoto, M., Hiroi, T., Bamberg, T. V., McGhee, J. R., &, Kiyono, H., (1996) Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues. Clinical and Experimental Immunology 103, 422 - 428.
13. Garlet, G. P., Martins, W. Jr, Ferreira, B. R., Milanezi, C. M., &, Silva, J. S., (2003) Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. Journal of Periodontal Research 38, 210 - 217.
14. Gemmell, E., &, Seymour, G. J., (2004) Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontology 2000 35, 21 - 41.
15. Gemmell, E., Yamazaki, K., &, Seymour, G. J., (2002) Destructive periodontitis lesions are determined by the nature of the lymphocytic response. Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists 13, 17 - 34.
16. Gonsky, R., Deem, R. L., &, Targan, S. R., (2009) Distinct methylation of IFNG in the gut. Journal of Interferon and Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research 29, 407 - 414.
17. Grunau, C., Clark, S. J., &, Rosenthal, A., (2001) Bisulphite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Research 29, E65 - 5.
18. Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilcek, J., Zinkernagel, R. M,. &, Aguet, M., (1993) Immune response in mice that lack the interferon-gamma receptor. Science 259, 1742 - 1745.
19. Jones, P. A., &, Laird, P. W., (1999) Cancer epigenetics comes of age. Nature Genetics 21, 163 - 167.
20. Kwon, N. H., Kim, J. S., Lee, J. Y., Oh, M. J., &, Choi, D. C., (2008) DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma. Journal of Clinical Immunology 28, 139 - 146.
21. Lappin, D. F., MacLeod, C. P., Kerr, A., Mitchell, T., &, Kinane, D. F., (2001) Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clinical and Experimental Immunology 123, 294 - 300.
22. Livak, K. J., &, Schmittgen, T. D., (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.) 25, 402 - 408.
23. Loe, H., Anerud, A., Boysen, H., &, Morrison, E., (1986) Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. Journal of Clinical Periodontology 13, 431 - 445.
24. Loe, H., Theilade, E., &, Jensen, S. B., (1965) Experimental gingivitis in man. Journal of Periodontology 36, 177 - 187.
25. Lu, B., Yu, H., Chow, C., Li, B., Zheng, W., Davis, R. J., &, Flavell, R. A., (2001) GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 14, 583 - 590.
26. Meda, L., Gasperini, S., Ceska, M., &, Cassatella, M. A., (1994) Modulation of proinflammatory cytokine release from human polymorphonuclear leukocytes by gamma interferon. Cellular Immunology 157, 448 - 461.
27. Nakajima, T., Yamashita, S., Maekita, T., Niwa, T., Nakazawa, K., &, Ushijima, T., (2009) The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. International Journal of Cancer. Journal International du Cancer 124, 905 - 910.
28. Nares, S., Moutsopoulos, N. M., Angelov, N., Rangel, Z. G., Munson, P. J., Sinha, N., &, Wahl, S. M., (2009) Rapid myeloid cell transcriptional and proteomic responses to periodontopathogenic Porphyromonas gingivalis. The American Journal of Pathology 174, 1400 - 1414.
29. Nichols, F. C., &, Garrison, S. W., (1987) Interferon-gamma potentiation of lipopolysaccharide-induced eicosanoid release from human monocytes. Journal of Interferon Research 7, 121 - 129.
30. Offenbacher, S., Barros, S. P., Singer, R. E., Moss, K., Williams, R. C., &, Beck, J. D., (2007) Periodontal disease at the biofilm-gingival interface. Journal of Periodontology 78, 1911 - 1925.
31. Reinhardt, R. A., McDonald, T. L., Bolton, R. W., DuBois, L. M., &, Kaldahl, W. B., (1989) IgG subclasses in gingival crevicular fluid from active versus stable periodontal sites. Journal of Periodontology 60, 44 - 50.
32. Rogus, J., Beck, J. D., Offenbacher, S., Huttner, K., Iacoviello, L., Latella, M. C., De Gaetano, M., Wang, H. Y., Kornman, K. S., &, Duff, G. W., (2008) IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Human Genetics 123, 387 - 398.
33. Salvi, G. E., Brown, C. E., Fujihashi, K., Kiyono, H., Smith, F. W., Beck, J. D., &, Offenbacher, S., (1998) Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. Journal of Periodontal Research 33, 212 - 225.
34. Seymour, G. J., Gemmell, E., Walsh, L. J., &, Powell, R. N., (1988) Immunohistological analysis of experimental gingivitis in humans. Clinical and Experimental Immunology 71, 132 - 137.
35. Shuto, T., Furuta, T., Oba, M., Xu, H., Li, J. D., Cheung, J., Gruenert, D. C., Uehara, A., Suico, M. A., Okiyoneda, T., &, Kai, H., (2006) Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. Federation of American Societies for Experimental Biology Journal 20, 782-784.
36. Smith, A. J., &, Humphries, S. E., (2009) Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine and Growth Factor Reviews 20, 43 - 59.
37. Takeichi, O., Haber, J., Kawai, T., Smith, D. J., Moro, I., &, Taubman, M. A., (2000) Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing. Journal of Dental Research 79, 1548 - 1555.
38. Watford, W. T., Moriguchi, M., Morinobu, A., &, O'Shea, J. J., (2003) The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine and Growth Factor Reviews 14, 361 - 368.
39. White, G. P., Hollams, E. M., Yerkovich, S. T., Bosco, A., Holt, B. J., Bassami, M. R., Kusel, M., Sly, P. D., &, Holt, P. G., (2006) CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics. Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 17, 557 - 564.
40. White, G. P., Watt, P. M., Holt, B. J., &, Holt, P. G., (2002) Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. Journal of Immunology (Baltimore, Md.:1950) 168, 2820 - 2827.
41. Wright, H. J., Matthews, J. B., Chapple, I. L., Ling-Mountford, N., &, Cooper, P. R., (2008) Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils. Journal of Immunology (Baltimore, Md.:1950) 181, 5775 - 5784.
42. Yamazaki, K., Nakajima, T., Gemmell, E., Polak, B., Seymour, G. J., &, Hara, K., (1994) IL-4- and IL-6-producing cells in human periodontal disease tissue Journal Of Oral Pathology & Medicine: official publication of the International Association of Oral Pathologists and the. American Academy of Oral Pathology 23, 347 - 353.
43. Yang, J., Murphy, T. L., Ouyang, W., &, Murphy, K. M., (1999) Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation. European Journal of Immunology 29, 548 - 555.
44. Zachrisson, B. U., (1968) A histological study of experimental gingivitis in man. Journal of Periodontal Research 3, 293 - 302.
45. Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., &, Offenbacher, S., (2010) Alteration of PTGS2 promoter methylation in chronic periodontitis. Journal of Dental Research 89, 133 - 137.