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Volumn 15, Issue 2, 2004, Pages 251-260

N-Acetylcysteine in the Prevention of Radiocontrast-Induced Nephropathy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CONTRAST MEDIUM; CYSTEINE; PARACETAMOL;

EID: 0942287101     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000107562.68920.92     Document Type: Review
Times cited : (191)

References (111)
  • 1
    • 0037419923 scopus 로고    scopus 로고
    • Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: A randomized controlled trial
    • Kay J, Chow WH, Chan TM, Lo SK, Kwok OH, Yip A, Fan K, Lee CH, Lam WF: Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: A randomized controlled trial. JAMA 289: 553-558, 2003
    • (2003) JAMA , vol.289 , pp. 553-558
    • Kay, J.1    Chow, W.H.2    Chan, T.M.3    Lo, S.K.4    Kwok, O.H.5    Yip, A.6    Fan, K.7    Lee, C.H.8    Lam, W.F.9
  • 3
    • 0036843034 scopus 로고    scopus 로고
    • Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy
    • Allaqaband S, Tumuluri R, Malik AM, Gupta A, Volkert P, Shalev Y, Bajwa TK: Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy. Catheter Cardiovasc Interv 57: 279-283, 2002
    • (2002) Catheter Cardiovasc Interv , vol.57 , pp. 279-283
    • Allaqaband, S.1    Tumuluri, R.2    Malik, A.M.3    Gupta, A.4    Volkert, P.5    Shalev, Y.6    Bajwa, T.K.7
  • 4
    • 0034691822 scopus 로고    scopus 로고
    • Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine
    • Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W: Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343: 180-184, 2000
    • (2000) N Engl J Med , vol.343 , pp. 180-184
    • Tepel, M.1    Van Der Giet, M.2    Schwarzfeld, C.3    Laufer, U.4    Liermann, D.5    Zidek, W.6
  • 5
    • 0037371588 scopus 로고    scopus 로고
    • Oral acetylcysteine does not protect renal function from moderate to high doses of intravenous radiographic contrast
    • Boccalandro F, Amhad M, Smalling RW, Sdringola S: Oral acetylcysteine does not protect renal function from moderate to high doses of intravenous radiographic contrast. Catheter Cardiovasc Interv 58: 336-341, 2003
    • (2003) Catheter Cardiovasc Interv , vol.58 , pp. 336-341
    • Boccalandro, F.1    Amhad, M.2    Smalling, R.W.3    Sdringola, S.4
  • 6
    • 0037120963 scopus 로고    scopus 로고
    • Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure
    • Shyu KG, Cheng JJ, Kuan P: Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol 40: 1383-1388, 2002
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1383-1388
    • Shyu, K.G.1    Cheng, J.J.2    Kuan, P.3
  • 8
    • 0036467721 scopus 로고    scopus 로고
    • Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial)
    • Diaz-Sandoval LJ, Kosowsky BD, Losordo DW: Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial). Am J Cardiol 89: 356-358, 2002
    • (2002) Am J Cardiol , vol.89 , pp. 356-358
    • Diaz-Sandoval, L.J.1    Kosowsky, B.D.2    Losordo, D.W.3
  • 9
    • 0035347150 scopus 로고    scopus 로고
    • Prevention of contrast media-induced renal dysfunction with prostaglandin E1: A randomized, double-blind, placebo-controlled study
    • Sketch MH Jr, Whelton A, Schollmayer E, Koch JA, Bernink PJ, Woltering F, Brinker J, Prostaglandin El Study Group: Prevention of contrast media-induced renal dysfunction with prostaglandin E1: A randomized, double-blind, placebo-controlled study. Am J Ther 8: 155-162, 2001
    • (2001) Am J Ther , vol.8 , pp. 155-162
    • Sketch Jr., M.H.1    Whelton, A.2    Schollmayer, E.3    Koch, J.A.4    Bernink, P.J.5    Woltering, F.6    Brinker, J.7
  • 10
    • 0025291287 scopus 로고
    • Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study
    • Rich MW, Crecelius CA: Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study. Arch Intern Med 150: 1237-1242, 1990
    • (1990) Arch Intern Med , vol.150 , pp. 1237-1242
    • Rich, M.W.1    Crecelius, C.A.2
  • 11
    • 0024552764 scopus 로고
    • Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study
    • Parfrey PS, Griffiths SM, Barrett BJ, Paul MD, Genge M, Withers J, Farid N, McManamon PJ: Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study. N Engl J Med 320: 143-149, 1989
    • (1989) N Engl J Med , vol.320 , pp. 143-149
    • Parfrey, P.S.1    Griffiths, S.M.2    Barrett, B.J.3    Paul, M.D.4    Genge, M.5    Withers, J.6    Farid, N.7    McManamon, P.J.8
  • 13
    • 0030661687 scopus 로고    scopus 로고
    • Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality
    • McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW: Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality. Am J Med 103: 368-375, 1997
    • (1997) Am J Med , vol.103 , pp. 368-375
    • McCullough, P.A.1    Wolyn, R.2    Rocher, L.L.3    Levin, R.N.4    O'Neill, W.W.5
  • 14
    • 0028033015 scopus 로고
    • Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents
    • Solomon R, Werner C, Mann D, D'Elia J, Silva P: Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents. N Engl J Med 331: 1416-1420, 1994
    • (1994) N Engl J Med , vol.331 , pp. 1416-1420
    • Solomon, R.1    Werner, C.2    Mann, D.3    D'Elia, J.4    Silva, P.5
  • 16
    • 0038581620 scopus 로고    scopus 로고
    • A 20-hour treatment for acute acetaminophen overdose
    • Yip L, Dart RC: A 20-hour treatment for acute acetaminophen overdose. N Engl J Med 348: 2471-2472, 2003
    • (2003) N Engl J Med , vol.348 , pp. 2471-2472
    • Yip, L.1    Dart, R.C.2
  • 18
    • 0029795838 scopus 로고    scopus 로고
    • Infarct Size Limitation: Acute N-acetylcysteine defense (ISLAND trial): Preliminary analysis and report after the first 30 patients
    • Sochman J, Vrbska J, Musilova B, Rocek M: Infarct Size Limitation: Acute N-acetylcysteine defense (ISLAND trial): Preliminary analysis and report after the first 30 patients. Clin Cardiol 9: 94-100, 1996
    • (1996) Clin Cardiol , vol.9 , pp. 94-100
    • Sochman, J.1    Vrbska, J.2    Musilova, B.3    Rocek, M.4
  • 20
    • 0019133598 scopus 로고
    • Nephrotoxicity of urographic radiocontrast drugs
    • Mudge GH: Nephrotoxicity of urographic radiocontrast drugs. Kid Int 18: 540-552, 1980
    • (1980) Kid Int , vol.18 , pp. 540-552
    • Mudge, G.H.1
  • 21
    • 0018391207 scopus 로고
    • Radiocontrast-induced acute renal failure: A clinical and pathophysiologic review
    • Byrd L, Sherman RL: Radiocontrast-induced acute renal failure: A clinical and pathophysiologic review. Medince 58: 270-279, 1979
    • (1979) Medince , vol.58 , pp. 270-279
    • Byrd, L.1    Sherman, R.L.2
  • 22
    • 0024761889 scopus 로고
    • Southwestern Internal Medicine Conference: Renal failure following radiolgic procedures
    • Cronin RE: Southwestern Internal Medicine Conference: Renal failure following radiolgic procedures. Am J Med Sci 298: 342-356, 1989
    • (1989) Am J Med Sci , vol.298 , pp. 342-356
    • Cronin, R.E.1
  • 25
    • 0020696423 scopus 로고
    • Renal vasoconstrictive response to contrast medium: The role of sodium balance and the rennin-angiotensin system
    • Larson TS, Hudson K, Mertz JI, Romero JC, Knox FG: Renal vasoconstrictive response to contrast medium: The role of sodium balance and the rennin-angiotensin system. J Lab Clin Med 101:385-391, 1983
    • (1983) J Lab Clin Med , vol.101 , pp. 385-391
    • Larson, T.S.1    Hudson, K.2    Mertz, J.I.3    Romero, J.C.4    Knox, F.G.5
  • 26
    • 0032587362 scopus 로고    scopus 로고
    • Comparative cytotoxicity of ionic and non-ionic radiocontrast agents on MDCK cell monolayers in vitro
    • Schick CS, Haller C: Comparative cytotoxicity of ionic and non-ionic radiocontrast agents on MDCK cell monolayers in vitro. Nephro Dial Trasnplant 14: 342-347, 1999
    • (1999) Nephro Dial Trasnplant , vol.14 , pp. 342-347
    • Schick, C.S.1    Haller, C.2
  • 27
    • 0014329480 scopus 로고
    • Renal hemodynamic effects of contrast media
    • Talner LB, Davidson AJ: Renal hemodynamic effects of contrast media. Inve Radiol 3: 310-317, 1968
    • (1968) Inve Radiol , vol.3 , pp. 310-317
    • Talner, L.B.1    Davidson, A.J.2
  • 28
    • 0026494585 scopus 로고
    • Contrast media and regional renal blood flow: A study of he effects of ionic and non-ionic monomeric and dimeric contrast media in the rat
    • Nygren A: Contrast media and regional renal blood flow: A study of he effects of ionic and non-ionic monomeric and dimeric contrast media in the rat. Acta Radiol 378: 123-135, 1992
    • (1992) Acta Radiol , vol.378 , pp. 123-135
    • Nygren, A.1
  • 30
    • 0026749298 scopus 로고
    • Effect of glycine and hypertophy on renal outer medullary hypoxic injury in ischemia reflow and contrast nephropathy
    • Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S: Effect of glycine and hypertophy on renal outer medullary hypoxic injury in ischemia reflow and contrast nephropathy. Am J Kid Dis 19: 578-586, 1992
    • (1992) Am J Kid Dis , vol.19 , pp. 578-586
    • Heyman, S.N.1    Brezis, M.2    Epstein, F.H.3    Spokes, K.4    Rosen, S.5
  • 31
    • 0032700452 scopus 로고    scopus 로고
    • Pathophysiology of radiocontrast nephropathy: A role for medullary hypoxia
    • Heyman SN, Reichman J, Brezis M: Pathophysiology of radiocontrast nephropathy: A role for medullary hypoxia. Invest Radiol 34: 685-691, 1999
    • (1999) Invest Radiol , vol.34 , pp. 685-691
    • Heyman, S.N.1    Reichman, J.2    Brezis, M.3
  • 32
    • 0028204036 scopus 로고
    • Radiocontrast nephropathy: A paradigm for the synergism between toxic and hypoxic insults in the kidney
    • Heyman SN, Rosen S, Brezis M: Radiocontrast nephropathy: A paradigm for the synergism between toxic and hypoxic insults in the kidney. Exp Nephrol 2: 153-157, 1994
    • (1994) Exp Nephrol , vol.2 , pp. 153-157
    • Heyman, S.N.1    Rosen, S.2    Brezis, M.3
  • 33
    • 0031915941 scopus 로고    scopus 로고
    • Injection of low and iso-osmolar contrast medium decreases oxygen tension in the renal medulla
    • Liss P, Nygren A, Erikson U, Ulfendahl HR: Injection of low and iso-osmolar contrast medium decreases oxygen tension in the renal medulla. Kidney Int 53: 698-702, 1998
    • (1998) Kidney Int , vol.53 , pp. 698-702
    • Liss, P.1    Nygren, A.2    Erikson, U.3    Ulfendahl, H.R.4
  • 34
    • 0035035078 scopus 로고    scopus 로고
    • Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy
    • Prasad PV, Priatna A, Spokes K, Epstein FH: Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy. J Magn Reson Imaging 13: 744-747, 2001.
    • (2001) J Magn Reson Imaging , vol.13 , pp. 744-747
    • Prasad, P.V.1    Priatna, A.2    Spokes, K.3    Epstein, F.H.4
  • 35
    • 0023760211 scopus 로고
    • Prerenal failure: A deleterious shift from renal compensation to decompenstation
    • Badr KF, Ichikawa IM: Prerenal failure: A deleterious shift from renal compensation to decompenstation. N Engl J Med 319: 623-629, 1988
    • (1988) N Engl J Med , vol.319 , pp. 623-629
    • Badr, K.F.1    Ichikawa, I.M.2
  • 36
    • 0028791280 scopus 로고
    • Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure
    • Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G, DeNicola L: Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure. J Am Soc Nephrol 6: 1451-1458, 1995
    • (1995) J Am Soc Nephrol , vol.6 , pp. 1451-1458
    • Russo, D.1    Minutolo, R.2    Cianciaruso, B.3    Memoli, B.4    Conte, G.5    DeNicola, L.6
  • 38
    • 0031283307 scopus 로고    scopus 로고
    • Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy
    • Pollock DM, Polakoski JS, AWegner CD, Opgenorth TJ: Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy. Ren Failure 19: 759-761, 1997
    • (1997) Ren Failure , vol.19 , pp. 759-761
    • Pollock, D.M.1    Polakoski, J.S.2    Awegner, C.D.3    Opgenorth, T.J.4
  • 39
    • 0035936681 scopus 로고    scopus 로고
    • The selective adenosine A1 recetor antagonist KW-3902 prevents radiocontrast media-induced nephropathy in rats with chronic nitric oxide deficiency
    • Yao K, Heyne H, Erley C, Risler T, Osswald H: The selective adenosine A1 recetor antagonist KW-3902 prevents radiocontrast media-induced nephropathy in rats with chronic nitric oxide deficiency. European J Pharm 414: 99-104, 2001
    • (2001) European J Pharm , vol.414 , pp. 99-104
    • Yao, K.1    Heyne, H.2    Erley, C.3    Risler, T.4    Osswald, H.5
  • 40
    • 0034531910 scopus 로고    scopus 로고
    • Effect of the selective adenosine A1-rescoptor antagonis KW-3902 on tubuloglomerular feedback in radiocontrast-media-induced nephropathy in rats with chronic nitric oxide deficiency
    • Yao K, Heyne N, Osswaold H: Effect of the selective adenosine A1-rescoptor antagonis KW-3902 on tubuloglomerular feedback in radiocontrast-media-induced nephropathy in rats with chronic nitric oxide deficiency. Jpn J Pharmacol 84: 347-350, 2000
    • (2000) Jpn J Pharmacol , vol.84 , pp. 347-350
    • Yao, K.1    Heyne, N.2    Osswaold, H.3
  • 41
    • 0032918019 scopus 로고    scopus 로고
    • Does hydration prevent radiocontrast-induced acute renal failure?
    • Erley CM: Does hydration prevent radiocontrast-induced acute renal failure? Nephrol Dial Transplant 14: 1064-1066, 1999
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 1064-1066
    • Erley, C.M.1
  • 42
    • 0031720937 scopus 로고    scopus 로고
    • Adenosine and extracellular volume in radiocontrast media-induced nephropathy
    • Erley CM, Heyn N, Rossmeir S, Vogel T, Risler T, Osswald H: Adenosine and extracellular volume in radiocontrast media-induced nephropathy. Kid Int 54[Suppl 67]: S192-S194, 1998
    • (1998) Kid Int , vol.54 , Issue.SUPPL. 67
    • Erley, C.M.1    Heyn, N.2    Rossmeir, S.3    Vogel, T.4    Risler, T.5    Osswald, H.6
  • 43
    • 0025861520 scopus 로고
    • Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact ragg kidneys
    • Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S: Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact ragg kidneys. J Clin Invest 88: 390-395, 1991
    • (1991) J Clin Invest , vol.88 , pp. 390-395
    • Brezis, M.1    Heyman, S.N.2    Dinour, D.3    Epstein, F.H.4    Rosen, S.5
  • 45
    • 0023142725 scopus 로고
    • Direct toxic effect of the radiocontrast agent diatrizoate on renal proximal tubule cells
    • Humes HD, Hunt DA, White MD: Direct toxic effect of the radiocontrast agent diatrizoate on renal proximal tubule cells. Am J Physiol 252: F246-F255, 1987
    • (1987) Am J Physiol , vol.252
    • Humes, H.D.1    Hunt, D.A.2    White, M.D.3
  • 46
    • 0023839856 scopus 로고
    • Comparison of the toxicity of the radiocontrast agents, iopamidol and diatrizoate, to rabbit renal proximal tubule cells in vitro
    • Messana JM, Cieslinski DA, Nguyen VD, Humes HD: Comparison of the toxicity of the radiocontrast agents, iopamidol and diatrizoate, to rabbit renal proximal tubule cells in vitro. J Pharmacol Exp Ther 244: 1139-1144, 1988
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 1139-1144
    • Messana, J.M.1    Cieslinski, D.A.2    Nguyen, V.D.3    Humes, H.D.4
  • 47
    • 0031925366 scopus 로고    scopus 로고
    • Radiocontrast-induced DNA fragmentation of renal tubular cells in vitro: Role of hypertonicity
    • Hizoh I, Strater J, Schick CS, Kubler W, Haller C: Radiocontrast-induced DNA fragmentation of renal tubular cells in vitro: Role of hypertonicity. Nephro Dial Transplant 13: 911-918, 1998
    • (1998) Nephro Dial Transplant , vol.13 , pp. 911-918
    • Hizoh, I.1    Strater, J.2    Schick, C.S.3    Kubler, W.4    Haller, C.5
  • 48
    • 0025019379 scopus 로고
    • Radiocontrast medium-induced declines in renal function: A role for oxygen free radicals
    • Bakris GL, Lass N, Gaber AO, Jones JD, Burnett JC Jr: Radiocontrast medium-induced declines in renal function: A role for oxygen free radicals. Am J Physiol 258: F115-F120, 1990
    • (1990) Am J Physiol , vol.258
    • Bakris, G.L.1    Lass, N.2    Gaber, A.O.3    Jones, J.D.4    Burnett Jr., J.C.5
  • 49
    • 0026562173 scopus 로고
    • Reduced activity of antioxidant enzymes underlies contrast media-induced renal injury in volume depletion
    • Yoshioka T, Fogo A, Becman JK: Reduced activity of antioxidant enzymes underlies contrast media-induced renal injury in volume depletion. Kidney Int 41: 1008-1015, 1992
    • (1992) Kidney Int , vol.41 , pp. 1008-1015
    • Yoshioka, T.1    Fogo, A.2    Becman, J.K.3
  • 50
    • 0024470728 scopus 로고
    • Contrast media-induced renal injury in volume depletion
    • Parvez Z, Rahman Ma, Moncada R: Contrast media-induced renal injury in volume depletion. Invest Radiol 24: 697-702, 1989
    • (1989) Invest Radiol , vol.24 , pp. 697-702
    • Parvez, Z.1    Rahman, Ma.2    Moncada, R.3
  • 51
    • 0032931817 scopus 로고    scopus 로고
    • PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress
    • Chan EH, Yu JS, Yang SD: PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress. J Cell Physiol 178: 397-408, 1999
    • (1999) J Cell Physiol , vol.178 , pp. 397-408
    • Chan, E.H.1    Yu, J.S.2    Yang, S.D.3
  • 52
    • 0036066083 scopus 로고    scopus 로고
    • Radiocontrast-induced renal tubular cell apoptosis
    • Hizoh I, Haller C: Radiocontrast-induced renal tubular cell apoptosis. Invest Radiol 37: 428-434, 2002
    • (2002) Invest Radiol , vol.37 , pp. 428-434
    • Hizoh, I.1    Haller, C.2
  • 53
    • 0038468868 scopus 로고    scopus 로고
    • Radiographic contrast media-induced tubular injury: Evaluation of oxidant stress and plasma membrane integrity
    • Zager RA, Johnson AC, Hanson SY: Radiographic contrast media-induced tubular injury: Evaluation of oxidant stress and plasma membrane integrity. Kidney Int 64: 128-139, 2003
    • (2003) Kidney Int , vol.64 , pp. 128-139
    • Zager, R.A.1    Johnson, A.C.2    Hanson, S.Y.3
  • 57
    • 0036001395 scopus 로고    scopus 로고
    • In vivo kinetic analysis of covalent binding between N-acetyl-L-cysteine and plasma protein through the formation of mixed disulfide in rats
    • Harada D, Naito S, Hiraoka I, Otagiri M: In vivo kinetic analysis of covalent binding between N-acetyl-L-cysteine and plasma protein through the formation of mixed disulfide in rats. Pharm Res 19: 615-620, 2002
    • (2002) Pharm Res , vol.19 , pp. 615-620
    • Harada, D.1    Naito, S.2    Hiraoka, I.3    Otagiri, M.4
  • 58
    • 0035869559 scopus 로고    scopus 로고
    • Determination of reduced, protein-unbound, and total concentrations of N-acetyl-L-cysteine and L-cysteine in rat plasma by postcolumn ligand substitution high-performance liquid chromatography
    • Harada D, Naito S, Kawauchi Y, Ishikawa K, Koshitani O, Hiraoka I, Otagiri M: Determination of reduced, protein-unbound, and total concentrations of N-acetyl-L-cysteine and L-cysteine in rat plasma by postcolumn ligand substitution high-performance liquid chromatography. Anal Biochem 290: 251-259, 2001
    • (2001) Anal Biochem , vol.290 , pp. 251-259
    • Harada, D.1    Naito, S.2    Kawauchi, Y.3    Ishikawa, K.4    Koshitani, O.5    Hiraoka, I.6    Otagiri, M.7
  • 60
    • 0023835113 scopus 로고
    • Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine
    • Olsson B, Johansson M, Gabrielsson J, Bolme P: Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34: 77-82, 1988
    • (1988) Eur J Clin Pharmacol , vol.34 , pp. 77-82
    • Olsson, B.1    Johansson, M.2    Gabrielsson, J.3    Bolme, P.4
  • 61
    • 0024512008 scopus 로고
    • Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration
    • Burgunder JM, Varriale A, Lauterburg BH: Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 36: 127-131, 1989
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 127-131
    • Burgunder, J.M.1    Varriale, A.2    Lauterburg, B.H.3
  • 62
    • 0026029981 scopus 로고
    • Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine
    • Bridgeman MM, Marsden M, MacNee W, Flenley DC, Ryle AP: Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine. Thorax 46: 39-42, 1991
    • (1991) Thorax , vol.46 , pp. 39-42
    • Bridgeman, M.M.1    Marsden, M.2    MacNee, W.3    Flenley, D.C.4    Ryle, A.P.5
  • 63
    • 0032562463 scopus 로고    scopus 로고
    • Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine
    • Tsikas D, Sandmann J, Ikic M, Fauler J, Stichtenoth DO, Frolich JC: Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine. J Chromatogr B Biomed Sci Appl. 708: 55-60, 1998
    • (1998) J Chromatogr B Biomed Sci Appl. , vol.708 , pp. 55-60
    • Tsikas, D.1    Sandmann, J.2    Ikic, M.3    Fauler, J.4    Stichtenoth, D.O.5    Frolich, J.C.6
  • 64
    • 0018403366 scopus 로고
    • Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes
    • Thor H, Moldeus P, Orrenius S: Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes. Arch Biochem Biophys 192: 405-413, 1979
    • (1979) Arch Biochem Biophys , vol.192 , pp. 405-413
    • Thor, H.1    Moldeus, P.2    Orrenius, S.3
  • 65
    • 0024331933 scopus 로고
    • Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability
    • Sjodin K, Nilsson E, Hallberg A, Tunek A: Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol 38: 3981-3985, 1989
    • (1989) Biochem Pharmacol , vol.38 , pp. 3981-3985
    • Sjodin, K.1    Nilsson, E.2    Hallberg, A.3    Tunek, A.4
  • 66
    • 0031853488 scopus 로고    scopus 로고
    • Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines
    • Uttamsingh V, Keller DA, Anders MW: Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. Chem Res Toxicol 11: 800-809, 1998
    • (1998) Chem Res Toxicol , vol.11 , pp. 800-809
    • Uttamsingh, V.1    Keller, D.A.2    Anders, M.W.3
  • 67
    • 0034084534 scopus 로고    scopus 로고
    • Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates
    • Uttamsingh V, Baggs RB, Krenitsky DM, Anders MW: Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates. Drug Metab Dispos 28: 625-632, 2000
    • (2000) Drug Metab Dispos , vol.28 , pp. 625-632
    • Uttamsingh, V.1    Baggs, R.B.2    Krenitsky, D.M.3    Anders, M.W.4
  • 68
    • 0023179937 scopus 로고
    • Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems
    • Cotgreave IA, Berggren M, Jones TW, Dawson J, Moldeus P: Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems. Biopharm Drug Dispos 8: 377-386, 1987
    • (1987) Biopharm Drug Dispos , vol.8 , pp. 377-386
    • Cotgreave, I.A.1    Berggren, M.2    Jones, T.W.3    Dawson, J.4    Moldeus, P.5
  • 69
    • 0013954684 scopus 로고
    • Metabolic studies with acetylcysteine
    • Sheffner AL: Metabolic studies with acetylcysteine. Biochem Pharmacol 15: 1523-1535, 1966
    • (1966) Biochem Pharmacol , vol.15 , pp. 1523-1535
    • Sheffner, A.L.1
  • 70
    • 0037414397 scopus 로고    scopus 로고
    • Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion
    • Sener G, Tosun O, Sehirli AO, Kacmaz A, Arbak S, Ersoy Y, Ayanoglu-Dulger G: Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci 72: 2707-2718, 2003
    • (2003) Life Sci , vol.72 , pp. 2707-2718
    • Sener, G.1    Tosun, O.2    Sehirli, A.O.3    Kacmaz, A.4    Arbak, S.5    Ersoy, Y.6    Ayanoglu-Dulger, G.7
  • 71
    • 0029154990 scopus 로고
    • Uptake and distribution of N-acetylcysteine in mice: Tissue-specific effects on glutathione concentrations
    • McLellan LI, Lewis AD, Hall DJ, Ansell JD, Wolf CR: Uptake and distribution of N-acetylcysteine in mice: Tissue-specific effects on glutathione concentrations. Carcinogenesis 16: 2099-2106, 1995
    • (1995) Carcinogenesis , vol.16 , pp. 2099-2106
    • McLellan, L.I.1    Lewis, A.D.2    Hall, D.J.3    Ansell, J.D.4    Wolf, C.R.5
  • 72
    • 0036292868 scopus 로고    scopus 로고
    • Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women
    • Roes EM, Raijmakers MT, Peters WH, Steegers EA: Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin Chem Lab Med 40: 496-498, 2002
    • (2002) Clin Chem Lab Med , vol.40 , pp. 496-498
    • Roes, E.M.1    Raijmakers, M.T.2    Peters, W.H.3    Steegers, E.A.4
  • 73
    • 0013897222 scopus 로고
    • The mucolytic action of acetylcysteine
    • Sheffner AL: The mucolytic action of acetylcysteine. Tuberculol Thorac Dis 23: 31-33, 1966
    • (1966) Tuberculol Thorac Dis , vol.23 , pp. 31-33
    • Sheffner, A.L.1
  • 74
    • 0023096396 scopus 로고
    • No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid
    • Cotgreave IA, Eklund A, Larsson K, Moldeus PW: No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid. Eur J Respir Dis 70: 73-7, 1987
    • (1987) Eur J Respir Dis , vol.70 , pp. 73-77
    • Cotgreave, I.A.1    Eklund, A.2    Larsson, K.3    Moldeus, P.W.4
  • 75
    • 0020427899 scopus 로고
    • Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen
    • Dahlin DC, Nelson SD: Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen. J Med Chem 25: 885-886, 1982
    • (1982) J Med Chem , vol.25 , pp. 885-886
    • Dahlin, D.C.1    Nelson, S.D.2
  • 77
    • 0020664865 scopus 로고
    • Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo
    • Lauterburg BH, Corcoran GB, Mitchell JR: Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 71: 980-991, 1983
    • (1983) J Clin Invest , vol.71 , pp. 980-991
    • Lauterburg, B.H.1    Corcoran, G.B.2    Mitchell, J.R.3
  • 78
    • 0022541787 scopus 로고
    • Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine in mice
    • Corcoran GB, Wong BK: Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine in mice. J Pharmacol Exp Ther 238: 54-61, 1986
    • (1986) J Pharmacol Exp Ther , vol.238 , pp. 54-61
    • Corcoran, G.B.1    Wong, B.K.2
  • 79
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: Mechanisms, mutation, and disease
    • Cooke MS, Evans MD, Dizdaroglu M, Lunec J: Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J 17: 1195-1214, 2003
    • (2003) FASEB J , vol.17 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 80
    • 0035240604 scopus 로고    scopus 로고
    • Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers in the prevention and treatment of cardiovascular disease
    • Nayak DU, Karmen C, Frishman WH, Vakili BA: Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers in the prevention and treatment of cardiovascular disease. Heart Dis 3: 28-45, 2001
    • (2001) Heart Dis , vol.3 , pp. 28-45
    • Nayak, D.U.1    Karmen, C.2    Frishman, W.H.3    Vakili, B.A.4
  • 81
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 6: 593-7, 1989
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 82
    • 0025291687 scopus 로고
    • Improved outcome of paracetamol -induced fulminant hepatic failure by late administration of acetylcysteine
    • Harrison PM, Keays R, Bray GP, Alexander GJ, Williams R: Improved outcome of paracetamol -induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 335: 1572-1573, 1990
    • (1990) Lancet , vol.335 , pp. 1572-1573
    • Harrison, P.M.1    Keays, R.2    Bray, G.P.3    Alexander, G.J.4    Williams, R.5
  • 83
    • 0025317268 scopus 로고
    • Glutathione: Toxicological implications
    • Reed DJ: Glutathione: Toxicological implications. Annu Rev Pharmacol Toxicol 30: 603-631, 1990
    • (1990) Annu Rev Pharmacol Toxicol , vol.30 , pp. 603-631
    • Reed, D.J.1
  • 84
    • 0025298097 scopus 로고
    • Glutathione-dependent protection against oxidative injury
    • Shan XQ, Aw TY, Jones DP: Glutathione-dependent protection against oxidative injury. Pharmacol Ther 47: 61-71, 1990
    • (1990) Pharmacol Ther , vol.47 , pp. 61-71
    • Shan, X.Q.1    Aw, T.Y.2    Jones, D.P.3
  • 85
    • 0032849141 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication
    • Skrzydlewska E, Farbiszewski R: Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication. Drug Alcohol Depend 57: 61-67, 1999
    • (1999) Drug Alcohol Depend , vol.57 , pp. 61-67
    • Skrzydlewska, E.1    Farbiszewski, R.2
  • 87
    • 0030759735 scopus 로고    scopus 로고
    • Antioxidant enzyme status in biliary obstructed rats: Effects of N-acetylcysteine
    • Pastor A, Collado PS, Almar M, Gonzalez-Gallego J: Antioxidant enzyme status in biliary obstructed rats: Effects of N-acetylcysteine. J Hepatol 27: 363-370, 1997
    • (1997) J Hepatol , vol.27 , pp. 363-370
    • Pastor, A.1    Collado, P.S.2    Almar, M.3    Gonzalez-Gallego, J.4
  • 88
    • 0038159965 scopus 로고
    • Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat
    • Sehirli AO, Sener G, Satiroglu H, Ayanoglu-Dulger G: Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat. J Nephrol 16: 75-80, 1993
    • (1993) J Nephrol , vol.16 , pp. 75-80
    • Sehirli, A.O.1    Sener, G.2    Satiroglu, H.3    Ayanoglu-Dulger, G.4
  • 89
    • 0023911442 scopus 로고
    • Renal work, glutathione and susceptibility to free radical-mediated postischemic injury
    • Paller MS: Renal work, glutathione and susceptibility to free radical-mediated postischemic injury. Kidney Int 33: 843-849, 1988
    • (1988) Kidney Int , vol.33 , pp. 843-849
    • Paller, M.S.1
  • 90
    • 84940619135 scopus 로고
    • Elevation of renal glutathione enhances ischemic injury
    • Scaduto RC, Martin VH: Elevation of renal glutathione enhances ischemic injury. Renol Physiol Biochem 14: 259-270, 1991
    • (1991) Renol Physiol Biochem , vol.14 , pp. 259-270
    • Scaduto, R.C.1    Martin, V.H.2
  • 92
    • 0038235849 scopus 로고    scopus 로고
    • N-acetylcysteine improves nitric oxide and alpha-adrenergic pathways in mesenteric beds of spontaneously hypertensive rats
    • Girouard H, Chulak C, Wu L, Lejossec M, de Champlain J: N-acetylcysteine improves nitric oxide and alpha-adrenergic pathways in mesenteric beds of spontaneously hypertensive rats. Am J Hypertens 16: 577-584, 2003
    • (2003) Am J Hypertens , vol.16 , pp. 577-584
    • Girouard, H.1    Chulak, C.2    Wu, L.3    Lejossec, M.4    De Champlain, J.5
  • 93
    • 0021838043 scopus 로고
    • N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin
    • Loscalzo J: N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J Clin Invest 76: 703-708, 1985
    • (1985) J Clin Invest , vol.76 , pp. 703-708
    • Loscalzo, J.1
  • 96
    • 0037249427 scopus 로고    scopus 로고
    • N-acetylcysteine ameliorates renal microcirculation: Studies in rats
    • Heyman SN, Goldfarb M, Shina A, Karmeli F, Rosen S: N-acetylcysteine ameliorates renal microcirculation: Studies in rats. Kidney Int 63: 634-641, 2003
    • (2003) Kidney Int , vol.63 , pp. 634-641
    • Heyman, S.N.1    Goldfarb, M.2    Shina, A.3    Karmeli, F.4    Rosen, S.5
  • 98
    • 0036295614 scopus 로고    scopus 로고
    • Objective response to treatment as a potential surrogate marker of survival in breast cancer
    • Bruzzi P: Objective response to treatment as a potential surrogate marker of survival in breast cancer. Ann N Y Acad Sci 963: 144-147, 2002
    • (2002) Ann N Y Acad Sci , vol.963 , pp. 144-147
    • Bruzzi, P.1
  • 99
    • 0028032093 scopus 로고
    • Risk of radiocontrast nephropathy in patients with and without diabetes mellitus
    • Weisberg LS, Kurnik PB, Kurnik BR: Risk of radiocontrast nephropathy in patients with and without diabetes mellitus. Kidney Int 45: 259-265, 1994
    • (1994) Kidney Int , vol.45 , pp. 259-265
    • Weisberg, L.S.1    Kurnik, P.B.2    Kurnik, B.R.3
  • 100
    • 0038648456 scopus 로고    scopus 로고
    • A rapid protocol for the prevention of contrast-induced renal dysfunction: The RAPPID study
    • Baker CS, Wragg A, Kumar S, De Palma R, Baker LR, Knight CJ: A rapid protocol for the prevention of contrast-induced renal dysfunction: The RAPPID study. J Am Coll Cardiol 41: 2114-2118, 2003
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2114-2118
    • Baker, C.S.1    Wragg, A.2    Kumar, S.3    De Palma, R.4    Baker, L.R.5    Knight, C.J.6
  • 101
    • 0041451602 scopus 로고    scopus 로고
    • Contrast-associated nephropathy and clinical outcome of patients with chronic renal insufficiency undergoing cardiac catheterization: Lack of additive benefit of acetylcysteine to saline hydration
    • Goldenberg I, Jones M, Metetzki S, Shecter M, Agranet O, Har-Zahev Y, Ellan D, Guetta V: Contrast-associated nephropathy and clinical outcome of patients with chronic renal insufficiency undergoing cardiac catheterization: Lack of additive benefit of acetylcysteine to saline hydration [Abstract]. J Am Coll Cardiol 41: 537A, 2003
    • (2003) J Am Coll Cardiol , vol.41
    • Goldenberg, I.1    Jones, M.2    Metetzki, S.3    Shecter, M.4    Agranet, O.5    Har-Zahev, Y.6    Ellan, D.7    Guetta, V.8
  • 103
    • 2442527691 scopus 로고    scopus 로고
    • Prophylactic acetylcysteine is not effective in preventng contrast-induced nephroapthy following coronary angiography
    • Oldemeyer JB, Cichowski EK, Wurdeman RL, Packard KA, Biddle WP, Mooss AN: Prophylactic acetylcysteine is not effective in preventng contrast-induced nephroapthy following coronary angiography [Abstract]. Am J Heart 146: E23, 2003
    • (2003) Am J Heart , vol.146
    • Oldemeyer, J.B.1    Cichowski, E.K.2    Wurdeman, R.L.3    Packard, K.A.4    Biddle, W.P.5    Mooss, A.N.6
  • 104
    • 0036718178 scopus 로고    scopus 로고
    • Contrast nephropathy in cardiac procedures: No advantages with prophylactic use of N-acetylcysteine (NAC)
    • Vallero A, Cesano G, Pozzato M, Garbo R, Minelli M, Quarello F, Formica M: Contrast nephropathy in cardiac procedures: No advantages with prophylactic use of N-acetylcysteine (NAC). G Ital Nefrol 19: 529-533, 2002
    • (2002) G Ital Nefrol , vol.19 , pp. 529-533
    • Vallero, A.1    Cesano, G.2    Pozzato, M.3    Garbo, R.4    Minelli, M.5    Quarello, F.6    Formica, M.7
  • 110
    • 0002944339 scopus 로고    scopus 로고
    • Contrast nephropathy
    • edited by Thomsen HS, Muller RN, Mattrey RF, Berlin, Springer Verlag
    • Thomsen HS: Contrast nephropathy. In: Trends in Contrast Media, edited by Thomsen HS, Muller RN, Mattrey RF, Berlin, Springer Verlag, 1999, pp 103-116
    • (1999) Trends in Contrast Media , pp. 103-116
    • Thomsen, H.S.1
  • 111
    • 0042496326 scopus 로고    scopus 로고
    • A randomized prospective trial to assess the role of saline hydration on the development of contrast nephrotoxicity
    • Trivedi HS, Moore H, Nasr S, Aggarwal K, Agrawal A, Goel P, Hewett J: A randomized prospective trial to assess the role of saline hydration on the development of contrast nephrotoxicity. Nephron Clin Pract 93: C29-C34, 2003
    • (2003) Nephron Clin Pract , vol.93
    • Trivedi, H.S.1    Moore, H.2    Nasr, S.3    Aggarwal, K.4    Agrawal, A.5    Goel, P.6    Hewett, J.7


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