Time Course of Increased Plasma Cytokines, Cortisol, and Urea Nitrogen in Pigs Following Intraperitoneal Injection of Lipopolysaccharide

Journal of Animal Science

Volumn 75, Issue 6, 1997, Pages 1514-1520

  Webel, D M ^a   Finck, B N ^a   Baker, D H ^a   Johnson, R W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cortisol; Cytokines; Lipopolysaccharides; Pigs

Indexed keywords

ANIMALIA; ESCHERICHIA COLI; SUS SCROFA; TRIXIS;

CYTOKINE; FATTY ACID; HYDROCORTISONE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; DOSE RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METABOLISM; RADIOIMMUNOASSAY; RANDOMIZATION; SWINE; TIME; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, NONESTERIFIED; FEMALE; HYDROCORTISONE; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; RADIOIMMUNOASSAY; RANDOM ALLOCATION; SWINE; TIME FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031158956     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1997.7561514x     Document Type: Article

References (36)

1. Adi, S., A. S. Pollock, J. K. Shigenage, A. H. Moser, K. R. Feingold, and C. Grunfeld. 1992. Role of monokines in the metabolic effects of endotoxin. J. Clin. Invest. 89:1603-1609.
2. Berkenbosch, F., J. van Oers, A. del Rey, F. Tilders, and H. Besedovsky. 1987. Corticotropin-releasing factor-producing neurons in the rat are activated by interleukin-1. Science (Wash DC) 238:524-526.
3. Bertini, R., M. Bainchi, and P. Ghezzi. 1988. Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exp. Med. 167:1708-1712.
4. Burger, W., E. M. Fennert, M. Poble, and H. Wesemier. 1992. C-reactive protein a characteristic feature of health control in swine. J. Vet. Med. A 39:635-638.
5. Coffey, R. D., and G. L. Cromwell. 1995. The impact of environment and antimicrobial agents on the growth response of early-weaned pigs to spray-dried porcine plasma. J. Anim. Sci. 73: 2532-2539
6. Flores, E. A., B. R. Bistrian, J. J. Pomposelli, C. A. Dinarello, G. L. Blackburn, and N. W. Istfan. 1989. Infusion of tumor necrosis factor/cachetin promotes muscle catabolism in the rat. J. Clin. Invest. 83:1614-1622.
7. Fong, Y., L. L. Moldawer, M. Marano, H. Wei, A. Barber, K. Manogue, K. J. Tracey, G. Kuo, D. A. Fischman, A. Cerami, and S. F. Lowry. 1989. Cachectin/TNF or IL-1α induces cachexia with redistribution of body proteins. Am. J. Physiol. 256:R659-R665.
8. Goodman, M. N. 1991. Tumor necrosis factor induces skeletal muscle protein breakdown in rats. Synergism with interleukin-1. Am. J. Physiol. 260:E727-E730.
9. Hall, W. F., T. E. Eurell, R. D. Hansen, and L. G. Herr. 1992. Serum haptoglobin concentration in swine naturally or experimentally infected with Actinobacillus pleuropneumoniae. J. Am. Vet. Med. Assoc. 210:1730-1733.
10. Hardardottir, I., C. Grunfeld, and K. R. Feingold. 1994. Effects of endotoxin and cytokines on lipid metabolism. Curr. Opin. Lipidol. 5:207-215.
11. Itoh, H., K. Tamura, M. Izumi, Y. Motoi, K. Kidoguchi, and Y. Funayama. 1992. The influence of age and health status on the serum alpha-1 acid glycoprotein levels of conventional and pathogen free pigs. Can. J. Vet. Res. 57:74-78.
12. Jepson, M. M., J. M. Bell, P. C. Bates, and D. J. Millward. 1986. The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochem. J. 235:329-336.
13. Johnson, R. W., M. J. Propes, and Y. Shavit. 1996. Corticosterone modulates behavioral and metabolic effects of lipopolysaccharide. Am. J. Physiol. 270:R192-R198.
14. Johnson, R. W. and E. von Borell. 1994. Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J. Anim. Sci. 72:309-314.
15. Johnson, R. W., E. von Borell, L. L. Anderson, L. D. Kojic, and J. E. Cunnick. 1994. Intracerebroventricular injection of corticotropin-releasing hormone in the pig: Acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 135:642-648.
16. Kakucska, I., Y. Qi, B. D. Clark, and R. M. Lechan. 1993. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology 133:815-821.
17. Kelley, K. W., R. W. Johnson, and R. Dantzer. 1994. Immunology discovers physiology. Vet. Immunol. Immunopathol. 43: 157-165.
18. Klasing, K. C., and B. J. Johnstone. 1991. Monokines in growth and development. Poult. Sci. 70:1781-1789.
19. Klasing, K. C., D. E. Laurin, R. K. Peng, and D. M. Fry. 1987. Immunologically mediated growth depression in chicks: Influence of feed intake, corticosterone and interleukin-1. J. Nutr. 117:1629-1637.
20. Knudson, P. J., C. A. Dinarello, and T. B. Strom. 1987. Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J. Immunol. 139:4129-4134.
21. Lacasca, D., B. Agli, and Y. Giudicelli. 1988. Permissive action of glucocorticoids on catecholamine-induced lipolysis: direct in vitro effects on the fat cell beta-adrenoreceptor-coupled-adenylate cyclase system. Biochem. Biophys. Res. Commun. 153: 489-497.
22. Lampreave, F., G. R. Nieves, M. A. Silvio, M. A Hernandez, H. K. Lorenzo, A. G. Huil, and A. Pineiro. 1994. Characterization of the acute phase serum protein response in pigs. Electrophoresis 15:672-676.
23. Lang, C. H., G. J. Bagby, C. Dobrescu, S. Nelson, and J. J. Spitzer. 1992. Modulation of glucose metabolic response to endotoxin by granulocyte colony-stimulating factor. Am. J. Physiol. 263: R1122-R1129.
24. Lang, C. H., and J. A. Spitzer. 1987. Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion. Metabolism 36:469-474.
25. McCallum, R. E., S. S. Lloyd, and S. R. Hyde. 1990. Enhanced TNF response in endotoxic mice after treatment with the glucocorticoid antagonist RU 486. In: A. Nowotny, J. J. Spitzer, and E. J. Diegler (Ed.) Cellular and Molecular Aspects of Endotoxin Reactions, p 493. Elsevier, New York.
26. Memon, R. A., K. R. Feingold, and C. Grunfeld. 1994. The effects of cytokines on intermediary metabolism. Endocrinologist 4: 56-63.
27. Millward, D. J., P. C. Bates, J. C. Brown, M. Cox, R. Gurgliano, M. Jepson, and J. Pell. 1985. Role of thyroid, insulin and corticosteroid hormones in the physiological regulation of proteolysis in muscle. In: E. A. Khairallah, J. S. Bond, and W. C. Bird (Ed.) Intracellular Protein Catabolism. Alan R. Liss, New York.
28. Murray, R. K., D. K. Granner, P. A. Mayes, and V. W. Rodwell. 1993. Harper's Biochemistry (23rd Ed.). Appleton and Lange, Norwalk, CT.
29. Murtaugh, M. P. 1994. Porcine cytokines. Vet. Immunol. Immunopathol. 43:37-44.
30. Nonogaki, K., G. M. Fuller, N. L. Fuentes, A. H. Moser, I. Staprans, C. Grunfeld, and K. R. Feingold. 1995. Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136: 2143-2149.
31. Reeds, P. J., C. R. Field, and F. Jahoor. 1994. Do the differences between the amino acid compositions of acute phase and muscle proteins have a bearing on nitrogen loss in traumatic states? J. Nutr. 124:906-910.
32. ® User's Guide (Version 6). SAS Inst. Inc., Cary, NC.
33. Skeggs, L. T. 1957. An automatic method for calorimetric analysis. Am. J. Clin. Pathol. 28:311.
34. Warren, E. J., B. N. Finck, S. Arkins, K. W. Kelley, R. W. Scamurra, M. P. Murtaugh, and R. W. Johnson. 1997. Coincidental changes in behavior and plasma cortisol in unrestrained pigs following intracerebroventricular injection of tumor necrosis factor-a. Endocrinology (In press).
35. Williams, N. H., T. S. Stahly, and D. R. Zimmerman. 1993. Impact of immune system activation and dietary amino acid regimen on nitrogen retention of pigs. J. Anim. Sci. 71(Suppl. 1):171 (Abstr.).
36. Wright, R., C. S. Holladay, and B. L. Spangelo. 1993. Lipopolysaccharide induces interleukin-6 release from rat peritoneal macrophages in vitro: Evidence for a novel mechanism. Circ. Shock 41:131-137.