Mechanisms and effectiveness of prebiotics in modifying the gastrointestinal microbiota for the management of digestive disorders

Proceedings of the Nutrition Society

Volumn 72, Issue 3, 2013, Pages 288-298

  Whelan, Kevin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Enteral nutrition; Inflammatory bowel disease; Irritable bowel syndrome; Microbiota; Prebiotics; Probiotics

Indexed keywords

CARBOHYDRATE; FRUCTOSE OLIGOSACCHARIDE; INULIN; OLIGOSACCHARIDE; PLACEBO; PREBIOTIC AGENT; SUCROSE;

BACTERIAL STRAIN; BIFIDOBACTERIACEAE; CLINICAL TRIAL (TOPIC); CLOSTRIDIA; CONFERENCE PAPER; CROHN DISEASE; DENDRITIC CELL; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; ENTERIC FEEDING; ENTERITIS; HUMAN; INFLAMMATION; INTESTINE FLORA; IRRITABLE COLON; NONHUMAN; PATHOGENESIS; PHENOTYPE;

ANIMALS; ENTERAL NUTRITION; GASTROINTESTINAL DISEASES; HUMANS; MICROBIOTA; PREBIOTICS;

EID: 84880891268     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665113001262     Document Type: Conference Paper

References (98)

1. Sekirov I, Russell SL, Antunes LC et al. (2010) Gut microbiota in health and disease. Physiol Rev 90, 859-904
2. Eckburg PB, Bik EM, Bernstein CN et al. (2005) Diversity of the human intestinal microbial flora. Science 308, 1635-1638
3. Qin J, Li R, Raes J et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65
4. Arumugam M, Raes J, Pelletier E et al. (2011) Enterotypes of the human gut microbiome. Nature 473, 174-180
5. Claesson MJ, Cusack S, O'Sullivan O et al. (2011) Composition, variability and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci USA 108, Suppl. 1, S4586-S4591
6. Tissier H (1898) Recherchessur la floreintestinale de nourissons (Research on the intestinal flora of infants). PhD Thesis, University of Paris, France.
7. Wu GD, Chen J, Hoffmann C et al. (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334, 105-108
8. Faith JJ, McNulty NP, Rey FE et al. (2011) Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science 333, 101-104
9. Gibson GR & Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125, 1401-1412
10. Roberfroid M, Gibson GR, Hoyles L et al. (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104, Suppl. 2, S1-S63
11. Sonnenburg ED, Zheng H, Joglekar P et al. (2010) Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell 141, 1241-1252
12. Van Loo J, Coussement P, de Leenheer L et al. (1995) On the presence of inulin and oligofructose as natural ingredients in the western diet. Crit Rev Food Sci Nutr 35, 525-552
13. Dunn S, Datta A, Kallis S et al. (2011) Validation of a food frequency questionnaire to measure intakes of inulin and oligofructose. Eur J Clin Nutr 65, 402-408
14. Moshfegh AJ, Friday JE, Goldman JP et al. (1999) Presence of inulin and oligofructose in the diets of Americans. J Nutr 129, Suppl. 7, S1407-S1411
15. Whelan K, Abrahmsohn O, David GJ et al. (2011) Fructan content of commonly consumed wheat, rye and gluten-free breads. Int J Food Sci Nutr 62, 498-503
16. Henderson L, Gregory J & Swan G. (2002) National Diet and Nutrition Survey: Adults Aged 19-64, vol
17. Biesiekierski JR, Rosella O, Rose R et al. (2011) Quantification of fructans, galacto-oligosaccharides and other shortchain carbohydrates in processed grains and cereals. J Hum Nutr Diet 24, 154-176
18. Gibson GR, Beatty ER, Wang X et al. (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975-982
19. Bouhnik Y, Vahedi K, Achour L et al. (1999) Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 129, 113-116
20. Davis LM, Marti'nez I, Walter J et al. (2010) A dose dependent impact of prebiotic galacto-oligosaccharides on the intestinal microbiota of healthy adults. Int J Food Microbiol 144, 285-292
21. Whelan K, Bartlett A, Datta A et al. (2009) Dietary and nondietary factors associated with the concentration of major GI microbiota in healthy subjects. Proc Nutr Soc 68, OCE1(E22)
22. Whelan K (2012) Modification of the gastrointestinal microbiota and its application to clinical nutrition. J Hum Nutr Diet 25, 297-299
23. Lebak KJ, Bliss DZ & Savik K (2003) What's new on defining diarrhea in tube-feeding studies? Clin Nurs Res 12, 174-204
24. Whelan K, Judd PA & Taylor MA (2003) Defining and reporting diarrhoea during enteral tube feeding: do health professionals agree? J Hum Nutr Diet 16, 21-26
25. Majid HA, Emery PW & Whelan K (2012) Definitions, attitudes and management practices in relation to diarrhea during enteral nutrition: a survey of patients, nurses and dietitians. Nutr Clin Pract 27, 252-260
26. Whelan K, Judd PA & Taylor MA (2004) Assessment of fecal output in patients receiving enteral tube feeding: validation of a novel chart. Eur J Clin Nutr 58, 1030-1037
27. Whelan K, Judd PA, Preedy VR et al. (2008) Covert assessment of concurrent and construct validity of a chart to characterize fecal output and diarrhea in patients receiving enteral nutrition. J Parenter Enteral Nutr 32, 160-168
28. Whelan K, Hill L, Preedy VR et al. (2006) Formula delivery in patients receiving enteral tube feeding on general hospital wards: the impact of nasogastric extubation and diarrhea. Nutrition 22, 1025-1031
29. Whelan K, Judd PA, Preedy VR et al. (2004) Enteral feeding: the effect on faecal output, the faecal microflora and SCFA concentrations. Proc Nutr Soc 63, 105-113
30. Guenter PA, Settle RG, Perlmutter S et al. (1991) Tube feeding related diarrhoea in acutely ill patients. J Parenter Enteral Nutr 15, 277-280
31. Sullivan A, Edlund C & Nord CE (2001) Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis 1, 101-114
32. Bliss DZ, Johnson S, Savik K et al. (1998) Acquisition of Clostridium difficile and Clostridium difficile-associated diarrhoea in hospitalised patients receiving tube feeding. Ann Intern Med 129, 1012-1019
33. Bowling TE, Raimundo AH, Grimble GK et al. (1993) Reversal by short-chain fatty acids of colonic fluid secretion induced by enteral feeding. Lancet 342, 1266-1268
34. Whelan K, Judd PA, Tuohy KM et al. (2009) Fecal microbiota in patients receiving enteral feeding are highly variable and may be altered in those who develop diarrhea. Am J Clin Nutr 89, 240-247
35. Whelan K, Judd PA, Preedy VR et al. (2005) Fructooligosaccharides and fiber partially prevent the alterations in fecal microbiota and short-chain fatty acid concentrations caused by standard enteral formula in healthy humans. J Nutr 135, 1896-1902
36. Benus R, van der Werf T, Welling GW et al. (2010) Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy humans. Br J Nutr 104, 693-700
37. Whelan K, Gibson GR, Judd PA et al. (2001) The role of probiotics and prebiotics in the management of diarrhoea associated with enteral tube feeding. J Hum Nutr Diet 14, 423-433
38. Whelan K (2007) Enteral tube feeding diarrhoea: manipulating the colonic microbiota with probiotics and prebiotics. Proc Nutr Soc 66, 299-306
39. Whelan K, Efthymiou L, Judd PA et al. (2006) Appetite during consumption of enteral formula as a sole source of nutrition: the effect of supplementing pea-fibre and fructooligosaccharides. Br J Nutr 96, 350-356
40. Schneider SM, Girard-Pipau F, Anty R et al. (2006) Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short-chain fatty acids and microbiota. Clin Nutr 25, 82-90
41. Majid HA, Emery PW & Whelan K (2011) Faecal microbiota and short-chain fatty acids in patients receiving enteral nutrition with standard or FOS and fibre-enriched formulas. J Hum Nutr Diet 24, 260-268
42. Sobotka L, Bra'tova M, Slemrová M et al. (1997) Inulin as the soluble fiber in liquid enteral nutrition. Nutrition 13, 21-25
43. Wierdsma NJ, van Bodegraven AA, Uitdehaag BM et al. (2009) Fructo-oligosaccharides and fibre in enteral nutrition has a beneficial influence on microbiota and gastrointestinal quality of life. Scand J Gastroenterol 44, 804-812
44. Majid HA, Cole J, Sherry T et al. (2012) A multi-centre, randomised, double-blind, controlled trial determining the effect of additional fructo-oligosaccharides on fecal microbiota and short-chain fatty acids among critical care patients receiving enteral nutrition. Gastroenterology 142, Suppl. 1, S909.
45. Hickson M, D'Souza AL, Muthu N et al. (2007) Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 335, 80.
46. Parkes GC, Sanderson JD & Whelan K (2009) The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea. Lancet Infect Dis 9, 237-244
47. Whelan K & Schneider SM (2011) Mechanisms, prevention, and management of diarrhea in enteral nutrition. Curr Opin Gastroenterol 27, 152-159
48. Bleichner G, Blehaut H, Mentec H et al. (1997) Saccharomyces boulardii prevents diarrhoea in critically ill tube fed patients. Intensive Care Med 23, 517-523
49. Frohmader TJ, Chaboyer WP, Robertson IK et al. (2010) Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: a pilot trial. Am J Crit Care 19, e1-e11
50. Whelan K & Myers CE (2010) Safety of probiotics in patients receiving nutritional support: a systematic review of case reports, randomized controlled trials, and nonrandomized trials. Am J Clin Nutr 91, 687-703
51. Loftus EV Jr. (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence and environmental influences. Gastroenterology 126, 1504-1517
52. Gerasimidis K, McGrogan P & Edwards CA (2011) The aetiology and impact of malnutrition in paediatric inflammatory bowel disease. J Hum Nutr Diet 24, 313-326
53. Prince A, Whelan K, Moosa A et al. (2011) Nutritional problems in inflammatory bowel disease: the patient perspective. J Crohn's Colitis 5, 443-450
54. Irvine EJ (1997) Quality of life issues in patients with inflammatory bowel disease. Am J Gastroenterol 92, Suppl. 12, S18-S24
55. Dignass A, Van Assche G, Lindsay JO et al. (2010) The second European evidence-based consensus on the diagnosis and management of Crohn's disease: current management. J Crohns Colitis 4, 28-62
56. Zachos M, Tondeur M & Griffiths AM (2007) Enteral nutritional therapy for induction of remission in Crohn's disease. Cochrane Database Syst Rev CD000542.
57. Lomer MC, Gourgey R & Whelan K (2013) Current practice in relation to nutritional assessment and dietary management of enteral nutrition in adults with Crohn's disease. J Hum Nutr Diet (In the Press).
58. Sellon RK, Tonkonogy S, Schultz M et al. (1998) Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin- 10-deficient mice. Infect Immun 66, 5224-5231
59. Fasoli R, Kettlewell MG, Mortensen N et al. (1990) Response to faecal challenge in defunctioned colonic Crohn's disease: prediction of long-term course. Br J Surg 77, 616-617
60. Hugot JP, Chamaillard M, Zouali H et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603
61. Lees CW, Barrett JC, Parkes M et al. (2011) New IBD genetics: common pathways with other diseases. Gut 60, 1739-1753
62. Willing BP, Dicksved J, Halfvarson J et al. (2010) A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139, 1844-1854
63. Tozer PJ, Whelan K, Phillips RK et al. (2009) Etiology of perianal Crohn's disease: role of genetic, microbiological, and immunological factors. Inflamm Bowel Dis 15, 1591- 1598
64. Benjamin JL, Hedin CRH, Koutsoumpas A et al. (2012) Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota. Inflamm Bowel Dis 18, 1092-1100
65. Seksik P, Rigottier-Gois L, Gramet G et al. (2003) Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon. Gut 52, 237-242
66. Sokol H, Seksik P, Furet JP et al. (2009) Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 15, 1183-1189
67. Hart AL, Lammers K & Brigidi P (2004) Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53, 1602-1609
68. Ng SC, Benjamin JL, McCarthy NE et al. (2012) The relationship between human intestinal dendritic cells, gut microbiota and disease activity in Crohn's disease. Inflamm Bowel Dis 17, 2027-2037
69. Sokol H, Pigneur B, Watterlot L et al. (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn's disease patients. Proc Natl Acad Sci USA 105, 16731-16736
70. Ramirez-Farias C, Slezak K, Fuller Z et al. (2009) Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr 101, 541-550
71. Cavaglieri CR, Nishiyama A, Fernandes LC et al. (2003) Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sci 73, 1683-1690
72. Hedin C, Whelan K & Lindsay JO (2007) Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials. Proc Nutr Soc 66, 307-315
73. Koleva PT, Valcheva RS, Sun X et al. (2012) Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats. Br J Nutr 108, 1633-1643
74. Lindsay JO, Whelan K, Stagg AJ et al. (2006) Clinical, microbiological and immunological effects of fructooligosaccharide in patients with Crohn's disease. Gut 55, 348-355
75. Benjamin JL, Hedin CRH, Koutsoumpas A et al. (2011) A randomised, double blind placebo controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut 60, 923-929
76. Joossens M, De Preter V, Ballet V et al. (2012) Effect of oligofructose-enriched inulin (OF-IN) on bacterial composition and disease activity of patients with Crohn's disease: results from a double-blinded randomised controlled trial. Gut 61, 958.
77. Hedin CR, Stagg AJ, Whelan K et al. (2012) Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention. Gut 61, 311-318
78. Hedin CRH, Mullard M, Sharratt E et al. (2010) Probiotic and prebiotic use in patients with inflammatory bowel disease: a case-control study. Inflamm Bowel Dis 16, 2099- 2108
79. Jonkers D, Penders J, Masclee A et al. (2012) Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients. Drugs 72, 803-823
80. Anderson JL, Edney RJ & Whelan K (2012) Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease. Aliment Pharmacol Ther 36, 503-516
81. Agarwal N & Spiegel BM (2011) The effect of irritable bowel syndrome on health-related quality of life and health care expenditures. Gastroenterol Clin North Am 40, 11-19
82. Parkes GC, Brostoff J, Whelan K et al. (2008) Gastrointestinal microbiota in irritable bowel syndrome: their role in its pathogenesis and treatment. Am J Gastroenterol 103, 1557-1567
83. Marshall JK, Thabane M, Garg AX et al. (2006) Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery. Gastroenterology 131, 445-450
84. Marshall JK, Thabane M, Garg AX et al. (2010) Eight year prognosis of post-infectious irritable bowel syndrome following waterborne bacterial dysentery. Gut 59, 605-611
85. Kassinen A, Krogius-Kurikka L, Mäkivuokko H et al. (2007) The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133, 24-33
86. Parkes GC, Rayment NB, Hudspith BN et al. (2012) Distinct microbial populations exist in the mucosa-associated microbiota of sub-groups of irritable bowel syndrome. Neurogastroenterol Motil 24, 31-39
87. Shah ED, Basseri RJ, Chong K et al. (2010) Abnormal breath testing in IBS: a meta-analysis. Dig Dis Sci 55, 2441-2449
88. Whelan K (2011) Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and systematic reviews. Curr Opin Clin Nutr Metab Care 14, 581-587
89. Hunter JO, Tuffnell Q & Lee AJ (1998) Controlled trial of oligofructose in the management of irritable bowel syndrome. J Nutr 129, Suppl. 7, S1451-S1453
90. Olesen M & Gudmand-Hoyer E (2000) Efficacy, safety, and tolerability of fructo-oligosaccharides in the treatment of irritable bowel syndrome. Am J Clin Nutr 72, 1570- 1575
91. Paineau D, Payen F, Panserieu S et al. (2008) The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders. Br J Nutr 99, 311-318
92. Silk DB, Davis A, Vulevic J et al. (2009) Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther 29, 508-518
93. Ong DK, Mitchell SB, Barrett JS et al. (2010) Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome. J Gastroenterol Hepatol 25, 1366-1373
94. Barrett JS, Gearry RB, Muir JG et al. (2010) Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon. Aliment Pharmacol Ther 31, 874-882
95. Staudacher H, Whelan K, Irving P et al. (2011) Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietaryadvice in patients with irritable bowel syndrome. J Hum Nutr Diet 24, 487-495
96. Staudacher HM, Lomer MCE, Anderson JL et al. (2012) Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. J Nutr 142, 1510- 1518
97. Simren M, Barbara G, Flint HJ et al. (2013) Intestinal microbiota in functional bowel disorders: a Rome Foundation report. Gut 62, 159-176
98. McKenzie YA, Alder A, Anderson W et al. (2012) British Dietetic Association evidence-based guidelines for the dietary management of irritable bowel syndrome in adults. J Hum Nutr Diet 25, 260-274