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Volumn 61, Issue 2, 2012, Pages 311-318

Family studies in Crohn's disease: New horizons in understanding disease pathogenesis, risk and prevention

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; C REACTIVE PROTEIN; CALGRANULIN; FUNGUS ANTIBODY;

EID: 84855206901     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2011.238568     Document Type: Review
Times cited : (34)

References (94)
  • 1
    • 76349114941 scopus 로고    scopus 로고
    • The natural history of adult Crohn's disease in population-based cohorts
    • Peyrin-Biroulet L, Loftus EV Jr, Colombel JF, et al. The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol 2010;105:289-97.
    • (2010) Am J Gastroenterol , vol.105 , pp. 289-297
    • Peyrin-Biroulet, L.1    Loftus Jr., E.V.2    Colombel, J.F.3
  • 2
    • 0037732998 scopus 로고    scopus 로고
    • Work losses related to inflammatory bowel disease in the United States: Results from the National Health Interview Survey
    • DOI 10.1016/S0002-9270(02)06007-0
    • Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol 2003;98:1064-72. (Pubitemid 36733768)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.5 , pp. 1064-1072
    • Longobardi, T.1    Jacobs, P.2    Bernstein, C.N.3
  • 3
    • 67049161224 scopus 로고    scopus 로고
    • A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005e07, showing increased incidence in Crohn's disease
    • Perminow G, Brackmann S, Lyckander LG, et al. A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005e07, showing increased incidence in Crohn's disease. Scand J Gastroenterol 2009;44:446-56.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 446-456
    • Perminow, G.1    Brackmann, S.2    Lyckander, L.G.3
  • 4
    • 65549129496 scopus 로고    scopus 로고
    • Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
    • Packey CD, Sartor RB. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr Opin Infect Dis 2009;22:292-301.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 292-301
    • Packey, C.D.1    Sartor, R.B.2
  • 5
    • 0027379179 scopus 로고
    • Prevalence and family risk of ulcerative colitis and Crohn's disease: An epidemiological study among Europeans and South Asians in Leicestershire
    • Probert CSJ, Jayanthi V, Hughes AO, et al. Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and South Asians in Leicestershire. Gut 1993;34:1547-51. (Pubitemid 23341846)
    • (1993) Gut , vol.34 , Issue.11 , pp. 1547-1551
    • Probert, C.S.J.1    Jayanthi, V.2    Hughes, A.O.3    Thompson, J.R.4    Wicks, A.C.B.5    Mayberry, J.F.6
  • 6
    • 0025897609 scopus 로고
    • Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease
    • Bennett RA, Rubin PH, Present DH. Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease. Gastroenterology 1991;100:1638-43.
    • (1991) Gastroenterology , vol.100 , pp. 1638-1643
    • Bennett, R.A.1    Rubin, P.H.2    Present, D.H.3
  • 7
    • 40849097776 scopus 로고    scopus 로고
    • Heritability in the genomics eradconcepts and misconceptions
    • Visscher PM, Hill WG, Wray NR. Heritability in the genomics eradconcepts and misconceptions. Nat Rev Genet 2008;9:255-66.
    • (2008) Nat Rev Genet , vol.9 , pp. 255-266
    • Visscher, P.M.1    Hill, W.G.2    Wray, N.R.3
  • 8
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • Tysk C, Lindberg E, Jarnerot G, et al. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988;29:990-6.
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3
  • 9
    • 38049078742 scopus 로고    scopus 로고
    • Longitudinal concordance for clinical characteristics in a SwedisheDanish twin population with inflammatory bowel disease
    • Halfvarson J, Jess T, Bodin L, et al. Longitudinal concordance for clinical characteristics in a SwedisheDanish twin population with inflammatory bowel disease. Inflamm Bowel Dis 2007;13:1536-44.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1536-1544
    • Halfvarson, J.1    Jess, T.2    Bodin, L.3
  • 10
    • 61649123125 scopus 로고    scopus 로고
    • Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort
    • Weersma RK, Stokkers PC, van Bodegraven AA, et al. Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut 2009;58:388-95.
    • (2009) Gut , vol.58 , pp. 388-395
    • Weersma, R.K.1    Stokkers, P.C.2    Van Bodegraven, A.A.3
  • 11
    • 78650097770 scopus 로고    scopus 로고
    • Genetics in twins with Crohn's disease: Less pronounced than previously believed?
    • Halfvarson J. Genetics in twins with Crohn's disease: less pronounced than previously believed? Inflamm Bowel Dis 2011;17:6-12.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 6-12
    • Halfvarson, J.1
  • 12
    • 0041353896 scopus 로고    scopus 로고
    • Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure
    • DOI 10.1007/s00384-003-0484-1
    • Hampe J, Heymann K, Krawczak M, et al. Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure. Int J Colorectal Dis 2003;18:413-17. (Pubitemid 37062732)
    • (2003) International Journal of Colorectal Disease , vol.18 , Issue.5 , pp. 413-417
    • Hampe, J.1    Heymann, K.2    Krawczak, M.3    Schreiber, S.4
  • 13
    • 0036288704 scopus 로고    scopus 로고
    • In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis
    • DOI 10.1136/gut.51.1.21
    • Bridger S, Lee JC, Bjarnason I, et al. In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis. Gut 2002;51:21-5. (Pubitemid 34717738)
    • (2002) Gut , vol.51 , Issue.1 , pp. 21-25
    • Bridger, S.1    Lee, J.C.W.2    Biarnason, I.3    Lennard, J.J.E.4    Macpherson, A.J.5
  • 14
    • 69249211059 scopus 로고    scopus 로고
    • Systematic review: The role of breastfeeding in the development of pediatric inflammatory bowel disease
    • Barclay AR, Russell RK, Wilson ML, et al. Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease. J Pediatr 2009;155:421-6.
    • (2009) J Pediatr , vol.155 , pp. 421-426
    • Barclay, A.R.1    Russell, R.K.2    Wilson, M.L.3
  • 16
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • WTCCC
    • WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 18
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 19
    • 77954133026 scopus 로고    scopus 로고
    • Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
    • Park JH, Wacholder S, Gail MH, et al. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet 2010;42:570-5.
    • (2010) Nat Genet , vol.42 , pp. 570-575
    • Park, J.H.1    Wacholder, S.2    Gail, M.H.3
  • 20
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009;461:747-53.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 21
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009;360:1696-8.
    • (2009) N Engl J Med , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 22
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010;141:1135-45.
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3
  • 23
    • 77954136357 scopus 로고    scopus 로고
    • Hints of hidden heritability in GWAS
    • Gibson G. Hints of hidden heritability in GWAS. Nat Genet 2010;42:558-60.
    • (2010) Nat Genet , vol.42 , pp. 558-560
    • Gibson, G.1
  • 24
    • 0020644991 scopus 로고
    • 51Chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease
    • Bjarnason I, O'Morain C, Levi AJ, et al. Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology 1983;85:318-22. (Pubitemid 13070915)
    • (1983) Gastroenterology , vol.85 , Issue.2 , pp. 318-322
    • Bjarnason, I.1    O'Morain, C.2    Levi, A.J.3    Peters, T.J.4
  • 25
  • 28
    • 33645049332 scopus 로고    scopus 로고
    • The primary defect in experimental ileitis originates from a nonhematopoietic source
    • Olson TS, Reuter BK, Scott KG, et al. The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med 2006;203:541-52.
    • (2006) J Exp Med , vol.203 , pp. 541-552
    • Olson, T.S.1    Reuter, B.K.2    Scott, K.G.3
  • 29
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 30
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives: A possible etiologic factor
    • Hollander D, Vadheim CM, Brettholz E, et al. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med 1986;105:883-5. (Pubitemid 17201765)
    • (1986) Annals of Internal Medicine , vol.105 , Issue.6 , pp. 883-885
    • Hollander, D.1    Vadheim, C.M.2    Brettholz, E.3
  • 31
    • 0028103683 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives
    • Munkholm P, Langholz E, Hollander D, et al. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut 1994;35:68-72. (Pubitemid 24059475)
    • (1994) Gut , vol.35 , Issue.1 , pp. 68-72
    • Munkholm, P.1    Langholz, E.2    Hollander, D.3    Thornberg, K.4    Orholm, M.5    Katz, K.D.6    Binder, V.7
  • 32
    • 0027293439 scopus 로고
    • Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
    • May GR, Sutherland LR, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 1993;104:1627-32. (Pubitemid 23235451)
    • (1993) Gastroenterology , vol.104 , Issue.6 , pp. 1627-1632
    • May, G.R.1    Sutherland, L.R.2    Meddings, J.B.3
  • 33
    • 0028878346 scopus 로고
    • CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability
    • Yacyshyn BR, Meddings JB. CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability. Gastroenterology 1995;108:132-7.
    • (1995) Gastroenterology , vol.108 , pp. 132-137
    • Yacyshyn, B.R.1    Meddings, J.B.2
  • 34
    • 0033003669 scopus 로고    scopus 로고
    • Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: An inherited defect in mucosal defence?
    • Soderholm JD, Olaison G, Lindberg E, et al. Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence? Gut 1999;44:96-100. (Pubitemid 29143287)
    • (1999) Gut , vol.44 , Issue.1 , pp. 96-100
    • Soderholm, J.D.1    Olaison, G.2    Lindberg, E.3    Hannestad, U.4    Vindels, A.5    Tysk, C.6    Jarnerot, G.7    Sjodahl, R.8
  • 35
    • 0035015975 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: A study in IBD families
    • Vermeire S, Peeters M, Vlietinck R, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: a study in IBD families. Inflamm Bowel Dis 2001;7:8-15.
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 8-15
    • Vermeire, S.1    Peeters, M.2    Vlietinck, R.3
  • 37
    • 33646246756 scopus 로고    scopus 로고
    • Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
    • D'Inca R, Annese V, di Leo V, et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment Pharmacol Ther 2006;23:1455-61.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1455-1461
    • D'Inca, R.1    Annese, V.2    Di Leo, V.3
  • 38
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
    • Irvine EJ, Marshall JK. Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 2000;119:1740-4. (Pubitemid 32198699)
    • (2000) Gastroenterology , vol.119 , Issue.6 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 39
    • 1842504079 scopus 로고    scopus 로고
    • Green banana and pectin improve small intestinal permeability and reduce fluid loss in Bangladeshi children with persistent diarrhea
    • DOI 10.1023/B:DDAS.0000020507.25910.cf
    • Rabbani GH, Teka T, Saha SK, et al. Green banana and pectin improve small intestinal permeability and reduce fluid loss in Bangladeshi children with persistent diarrhea. Dig Dis Sci 2004;49:475-84. (Pubitemid 38453569)
    • (2004) Digestive Diseases and Sciences , vol.49 , Issue.3 , pp. 475-484
    • Rabbani, G.H.1    Teka, T.2    Saha, S.K.3    Zaman, B.4    Majid, N.5    Khatun, M.6    Wahed, M.A.7    Fuchs, G.J.8
  • 40
    • 78649983465 scopus 로고    scopus 로고
    • Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats
    • Schepens MA, Rijnierse A, Schonewille AJ, et al. Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats. Br J Nutr 2010;104:1780-6.
    • (2010) Br J Nutr , vol.104 , pp. 1780-1786
    • Schepens, M.A.1    Rijnierse, A.2    Schonewille, A.J.3
  • 41
    • 77957201539 scopus 로고    scopus 로고
    • Translocation of Crohn's disease Escherichia coli across M-cells: Contrasting effects of soluble plant fibres and emulsifiers
    • Roberts CL, Keita AV, Duncan SH, et al. Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 2010;59:1331-9.
    • (2010) Gut , vol.59 , pp. 1331-1339
    • Roberts, C.L.1    Keita, A.V.2    Duncan, S.H.3
  • 42
    • 84855186431 scopus 로고    scopus 로고
    • Dietary fructo-oligosaccharide intakes in patients with active Crohn's disease
    • Kelly LM, Benjamin JL, Koutsoumpas A, et al. Dietary fructo- oligosaccharide intakes in patients with active Crohn's disease. J Hum Nutr Diet 2010;23:323.
    • (2010) J Hum Nutr Diet , vol.23 , pp. 323
    • Kelly, L.M.1    Benjamin, J.L.2    Koutsoumpas, A.3
  • 43
    • 78649620656 scopus 로고    scopus 로고
    • Probiotic and prebiotic use in patients with inflammatory bowel disease: A caseecontrol study
    • Hedin CR, Mullard M, Sharratt E, et al. Probiotic and prebiotic use in patients with inflammatory bowel disease: a caseecontrol study. Inflamm Bowel Dis 2010;16:2099-108.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 2099-2108
    • Hedin, C.R.1    Mullard, M.2    Sharratt, E.3
  • 44
    • 0028808680 scopus 로고
    • Intestinal permeability changes during the first month: Effect of natural versus artificial feeding
    • Catassi C, Bonucci A, Coppa GV, et al. Intestinal permeability changes during the first month: effect of natural versus artificial feeding. J Pediatr Gastroenterol Nutr 1995;21:383-6.
    • (1995) J Pediatr Gastroenterol Nutr , vol.21 , pp. 383-386
    • Catassi, C.1    Bonucci, A.2    Coppa, G.V.3
  • 45
    • 67649208478 scopus 로고    scopus 로고
    • The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
    • Ehrchen JM, Sunderkotter C, Foell D, et al. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 2009;86:557-66.
    • (2009) J Leukoc Biol , vol.86 , pp. 557-566
    • Ehrchen, J.M.1    Sunderkotter, C.2    Foell, D.3
  • 46
    • 0033795259 scopus 로고    scopus 로고
    • A simple method for assessing intestinal inflammation in Crohn's disease
    • Tibble J, Teahon K, Thjodleifsson B, et al. A simple method for assessing intestinal inflammation in Crohn's disease. Gut 2000;47:506-13.
    • (2000) Gut , vol.47 , pp. 506-513
    • Tibble, J.1    Teahon, K.2    Thjodleifsson, B.3
  • 47
    • 77955116467 scopus 로고    scopus 로고
    • Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: Diagnostic meta-analysis
    • van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. BMJ 2010;341:c3369.
    • (2010) BMJ , vol.341
    • Van Rheenen, P.F.1    Van De Vijver, E.2    Fidler, V.3
  • 49
    • 84855200077 scopus 로고    scopus 로고
    • Intestinal permeability, fecal calprotectin and CARD 15 mutations in first degree relatives of Crohn's disease patients
    • D'Incà R, Oliva L, Latiano A, et al. Intestinal permeability, fecal calprotectin and CARD 15 mutations in first degree relatives of Crohn's disease patients. Gastroenterology 2008;134: A497-8.
    • (2008) Gastroenterology , vol.134
    • D'Incà, R.1    Oliva, L.2    Latiano, A.3
  • 50
    • 78649334250 scopus 로고    scopus 로고
    • Subclinical intestinal inflammation in siblings of children with Crohn's disease
    • Pham M, Leach ST, Lemberg DA, et al. Subclinical intestinal inflammation in siblings of children with Crohn's disease. Dig Dis Sci 2010;55:3502-7.
    • (2010) Dig Dis Sci , vol.55 , pp. 3502-3507
    • Pham, M.1    Leach, S.T.2    Lemberg, D.A.3
  • 51
    • 0034234796 scopus 로고    scopus 로고
    • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
    • Tibble JA, Sigthorsson G, Bridger S, et al. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 2000;119:15-22. (Pubitemid 30452574)
    • (2000) Gastroenterology , vol.119 , Issue.1 , pp. 15-22
    • Tibble, J.A.1    Sigthorsson, G.2    Bridger, S.3    Fagerhol, M.K.4    Bjarnason, I.5
  • 52
    • 0021923695 scopus 로고
    • Familial occurrence of complement dysfunction in Crohn's disease: Correlation with intestinal symptoms and hypercatabolism of complement
    • Elmgreen J, Both H, Binder V. Familial occurrence of complement dysfunction in Crohn's disease: correlation with intestinal symptoms and hypercatabolism of complement. Gut 1985;26:151-7. (Pubitemid 15105141)
    • (1985) Gut , vol.26 , Issue.2 , pp. 151-157
    • Elmgreen, J.1    Both, H.2    Binder, V.3
  • 54
    • 0141519369 scopus 로고    scopus 로고
    • Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease
    • DOI 10.1097/00054725-200309000-00003
    • Klebl FH, Bataille F, Bertea CR, et al. Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease. Inflamm Bowel Dis 2003;9:302-7. (Pubitemid 37161749)
    • (2003) Inflammatory Bowel Diseases , vol.9 , Issue.5 , pp. 302-307
    • Klebl, F.H.1    Bataille, F.2    Bertea, C.R.3    Herfarth, H.4    Hofstadter, F.5    Scholmerich, J.6    Rogler, G.7
  • 55
    • 1542725070 scopus 로고    scopus 로고
    • Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease
    • DOI 10.1097/00054725-200403000-00006
    • Konrad A, Rutten C, Flogerzi B, et al. Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease. Inflamm Bowel Dis 2004;10:97-105. (Pubitemid 38332168)
    • (2004) Inflammatory Bowel Diseases , vol.10 , Issue.2 , pp. 97-105
    • Konrad, A.1    Rutten, C.2    Flogerzi, B.3    Styner, M.4    Goke, B.5    Seibold, F.6
  • 57
    • 23744480856 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease
    • DOI 10.1136/gut.2004.060228
    • Israeli E, Grotto I, Gilburd B, et al. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Gut 2005;54:1232-6. (Pubitemid 41192480)
    • (2005) Gut , vol.54 , Issue.9 , pp. 1232-1236
    • Israeli, E.1    Grotto, I.2    Gilburd, B.3    Balicer, R.D.4    Goldin, E.5    Wiik, A.6    Shoenfeld, Y.7
  • 59
    • 0036946773 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: Potential clinical value
    • DOI 10.1159/000066760
    • Glas J, Torok HP, Vilsmaier F, et al. Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: potential clinical value. Digestion 2002;66:173-7. (Pubitemid 36096844)
    • (2002) Digestion , vol.66 , Issue.3 , pp. 173-177
    • Glas, J.1    Torok, H.-P.2    Vilsmaier, F.3    Herbinger, K.-H.4    Hoelscher, M.5    Folwaczny, C.6
  • 61
    • 0026750310 scopus 로고
    • Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease
    • Lindberg E, Magnusson KE, Tysk C, et al. Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease. Gut 1992;33:909-13.
    • (1992) Gut , vol.33 , pp. 909-913
    • Lindberg, E.1    Magnusson, K.E.2    Tysk, C.3
  • 62
    • 33645998461 scopus 로고    scopus 로고
    • Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease
    • Mei L, Targan SR, Landers CJ, et al. Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease. Gastroenterology 2006;130:1078-85.
    • (2006) Gastroenterology , vol.130 , pp. 1078-1085
    • Mei, L.1    Targan, S.R.2    Landers, C.J.3
  • 68
    • 0030881823 scopus 로고    scopus 로고
    • Antinuclear autoantibodies in patients with inflammatory bowel disease: High prevalence in first-degree relatives
    • DOI 10.1023/A:1018832608899
    • Folwaczny C, Noehl N, Endres SP, et al. Antinuclear autoantibodies in patients with inflammatory bowel disease. High prevalence in first-degree relatives. Dig Dis Sci 1997;42:1593-7. (Pubitemid 27394579)
    • (1997) Digestive Diseases and Sciences , vol.42 , Issue.8 , pp. 1593-1597
    • Folwaczny, C.1    Noehl, N.2    Endres, S.P.3    Heldwein, W.4    Loeschke, K.5    Fricke, H.6
  • 69
    • 0024560549 scopus 로고
    • High prevalence of antibodies to intestinal epithelial antigens in patients with inflammatory bowel disease and their relatives
    • Fiocchi C, Roche JK, Michener WM. High prevalence of antibodies to intestinal epithelial antigens in patients with inflammatory bowel disease and their relatives. Ann Intern Med 1989;110:786-94. (Pubitemid 19128996)
    • (1989) Annals of Internal Medicine , vol.110 , Issue.10 , pp. 786-794
    • Fiocchi, C.1    Roche, J.K.2    Michener, W.M.3
  • 70
    • 0030917132 scopus 로고    scopus 로고
    • Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives
    • DOI 10.1016/S0016-5085(97)70085-4
    • Folwaczny C, Noehl N, Tschop K, et al. Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives. Gastroenterology 1997;113:101-6. (Pubitemid 27281763)
    • (1997) Gastroenterology , vol.113 , Issue.1 , pp. 101-106
    • Folwaczny, C.1    Noehl, N.2    Tschop, K.3    Endres, S.P.4    Heldwein, W.5    Loeschke, K.6    Fricke, H.7
  • 72
    • 33645026321 scopus 로고    scopus 로고
    • Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease
    • Kraus TA, Cheifetz A, Toy L, et al. Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflamm Bowel Dis 2006;12:82-8.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 82-88
    • Kraus, T.A.1    Cheifetz, A.2    Toy, L.3
  • 74
    • 33645549932 scopus 로고    scopus 로고
    • A subgroup of first-degree relatives of Crohn's disease patients shows a profile of inflammatory markers in the blood which is more typical of Crohn's disease patients than of normal individuals
    • Efrat B, Iris G, Wang H, et al. A subgroup of first-degree relatives of Crohn's disease patients shows a profile of inflammatory markers in the blood which is more typical of Crohn's disease patients than of normal individuals. Mediators Inflamm 2006;2006:74785.
    • (2006) Mediators Inflamm , vol.2006 , pp. 74785
    • Efrat, B.1    Iris, G.2    Wang, H.3
  • 75
    • 0347949513 scopus 로고    scopus 로고
    • Quantitative and functional characteristics of intestinal-homing memory T cells: Analysis of Crohn's disease patients and healthy controls
    • DOI 10.1111/j.1365-2249.2004.02347.x
    • Hart AL, Kamm MA, Knight SC, et al. Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls. Clin Exp Immunol 2004;135:137-45. (Pubitemid 38067938)
    • (2004) Clinical and Experimental Immunology , vol.135 , Issue.1 , pp. 137-145
    • Hart, A.L.1    Kamm, M.A.2    Knight, S.C.3    Stagg, A.J.4
  • 76
    • 0031052899 scopus 로고    scopus 로고
    • 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation
    • Meenan J, Spaans J, Grool TA, et al. Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. Gut 1997;40:241-6. (Pubitemid 27093101)
    • (1997) Gut , vol.40 , Issue.2 , pp. 241-246
    • Meenan, J.1    Spaans, J.2    Grool, T.A.3    Pals, S.T.4    Tytgat, G.N.J.5    Van Deventer, S.J.H.6
  • 77
    • 39649121919 scopus 로고    scopus 로고
    • Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
    • DOI 10.1002/ibd.20315
    • Schmechel S, Konrad A, Diegelmann J, et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008;14:204-12. (Pubitemid 351288041)
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.2 , pp. 204-212
    • Schmechel, S.1    Konrad, A.2    Diegelmann, J.3    Glas, J.4    Wetzke, M.5    Paschos, E.6    Lohse, P.7    Goke, B.8    Brand, S.9
  • 78
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • DOI 10.1056/NEJMra020831
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29. (Pubitemid 34851835)
    • (2002) New England Journal of Medicine , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 79
    • 0345830652 scopus 로고    scopus 로고
    • Dysbiosis in inflammatory bowel disease
    • DOI 10.1136/gut.53.1.1
    • Tamboli CP, Neut C, Desreumaux P, et al. Dysbiosis in inflammatory bowel disease. Gut 2004;53:1-4. (Pubitemid 38082999)
    • (2004) Gut , vol.53 , Issue.1 , pp. 1-4
    • Tamboli, C.P.1    Neut, C.2    Desreumaux, P.3    Colombel, J.F.4
  • 80
    • 0031684010 scopus 로고    scopus 로고
    • Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria
    • Zoetendal EG, Akkermans AD, De Vos WM. Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 1998;64:3854-9. (Pubitemid 28462983)
    • (1998) Applied and Environmental Microbiology , vol.64 , Issue.10 , pp. 3854-3859
    • Zoetendal, E.G.1    Akkermans, A.D.L.2    De Vos, W.M.3
  • 81
    • 70349488325 scopus 로고    scopus 로고
    • Low counts of Faecalibacterium prausnitzii in colitis microbiota
    • Sokol H, Seksik P, Furet JP, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 2009;15:1183-9.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1183-1189
    • Sokol, H.1    Seksik, P.2    Furet, J.P.3
  • 82
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 2008;105:16731-6.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 83
    • 84855198495 scopus 로고    scopus 로고
    • The Crohn's disease associated NOD2 mutations predispose to dysbiosis
    • Neut C, Sivignon A, Joossens M, et al. The Crohn's disease associated NOD2 mutations predispose to dysbiosis. Gastroenterology 2007;132:T1764.
    • (2007) Gastroenterology , vol.132
    • Neut, C.1    Sivignon, A.2    Joossens, M.3
  • 84
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    • Joossens M, Huys G, Cnockaert M, et al. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 2011;60:631-7.
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1    Huys, G.2    Cnockaert, M.3
  • 85
    • 28944442466 scopus 로고    scopus 로고
    • Investigations into the influence of host genetics on the predominant eubacteria in the faecal microflora of children
    • DOI 10.1099/jmm.0.46189-0
    • Stewart JA, Chadwick VS, Murray A. Investigations into the influence of host genetics on the predominant eubacteria in the faecal microflora of children. J Med Microbiol 2005;54:1239-42. (Pubitemid 41783834)
    • (2005) Journal of Medical Microbiology , vol.54 , Issue.12 , pp. 1239-1242
    • Stewart, J.A.1    Chadwick, V.S.2    Murray, A.3
  • 86
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing BP, Dicksved J, Halfvarson J, et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 2010;139:1844-54.
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3
  • 88
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature 2009;457:480-4.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1    Hamady, M.2    Yatsunenko, T.3
  • 89
    • 33645760679 scopus 로고    scopus 로고
    • Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    • Visscher PM, Medland SE, Ferreira MA, et al. Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet 2006;2:-41.
    • (2006) PLoS Genet , vol.2 , pp. 41
    • Visscher, P.M.1    Medland, S.E.2    Ferreira, M.A.3
  • 90
    • 0033965041 scopus 로고    scopus 로고
    • Relationship between intestinal permeability and calprotectin concentration in gut lavage fluid
    • Berstad A, Arslan G, Folvik G. Relationship between intestinal permeability and calprotectin concentration in gut lavage fluid. Scand J Gastroenterol 2000;35:64-9. (Pubitemid 30066774)
    • (2000) Scandinavian Journal of Gastroenterology , vol.35 , Issue.1 , pp. 64-69
    • Berstad, A.1    Arslan, G.2    Folvik, G.3
  • 92
    • 74049121872 scopus 로고    scopus 로고
    • Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease
    • Joossens M, Van SK, Branche J, et al. Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease. Inflamm Bowel Dis 2010;16:58-67.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 58-67
    • Joossens, M.1    Van, S.K.2    Branche, J.3
  • 93
    • 77951771367 scopus 로고    scopus 로고
    • Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers
    • Joshi S, Lewis SJ, Creanor S, et al. Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem 2010;47:259-63.
    • (2010) Ann Clin Biochem , vol.47 , pp. 259-263
    • Joshi, S.1    Lewis, S.J.2    Creanor, S.3
  • 94
    • 8144221776 scopus 로고    scopus 로고
    • Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects
    • DOI 10.1128/AEM.70.10.6113-6122.2004
    • Woodmansey EJ, McMurdo ME, Macfarlane GT, et al. Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects. Appl Environ Microbiol 2004;70:6113-22. (Pubitemid 39471860)
    • (2004) Applied and Environmental Microbiology , vol.70 , Issue.10 , pp. 6113-6122
    • Woodmansey, E.J.1    McMurdo, M.E.T.2    Macfarlane, G.T.3    Macfarlane, S.4


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