IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R

Blood

Volumn 121, Issue 22, 2013, Pages 4484-4492

  Martin, Christopher E ^a,b,c   Van Leeuwen, Ester M M ^b   Im, Se Jin ^d   Roopenian, Derry C ^e   Sung, Young Chul ^d,f   Surh, Charles D ^b,c,d  

^a Doctoral Program in Chemical and Biological Sciences   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

^e JACKSON LABORATORY   (United States)

^f POSTECH Biotech Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CHEMOKINE RECEPTOR CCR7; FC RECEPTOR; FCGAMMA RECEPTOR; FCRN PROTEIN; FINGOLIMOD; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; NEUTRALIZING MONOCLONAL ANTIBODY CLONE M25; PERTUSSIS TOXIN; RECOMBINANT INTERLEUKIN 7; UNCLASSIFIED DRUG; (3AS,4S,9BS)-N-(2-(8-CYANO-1-FORMYL-2,3,3A,4,5,9B-HEXAHYDRO-1H-PYRROLO(3,2-C)QUINOLIN-4-YL)-2-METHYLPROPYL)-4,6-DIFLUOROBENZOFURAN-2-CARBOXYAMIDE; (3AS,4S,9BS) N (2 (8 CYANO 1 FORMYL 2,3,3A,4,5,9B HEXAHYDRO 1H PYRROLO(3,2 C)QUINOLIN 4 YL) 2 METHYLPROPYL) 4,6 DIFLUOROBENZOFURAN 2 CARBOXYAMIDE; BENZOFURAN DERIVATIVE; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; INTERLEUKIN 7 RECEPTOR; QUINOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL EXPANSION; CELL HOMING; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG HALF LIFE; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; MITOGENESIS; MITOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; BINDING COMPETITION; FEMALE; IMMUNOLOGY; MALE; METABOLISM; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BENZOFURANS; BINDING, COMPETITIVE; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; INTERLEUKIN-7; MALE; MICE; MICE, TRANSGENIC; QUINOLINES; RECEPTORS, FC; RECEPTORS, INTERLEUKIN-7; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTE SUBSETS;

MLCS; MLOWN;

EID: 84880848605     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-08-449215     Document Type: Article

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