Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4895-4902

  Sun, Juan ^a   Cao, Ning ^a   Zhang, Xiao Min ^a   Yang, Yu Shun ^a   Zhang, Yan Bin ^a   Wang, Xiao Ming ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Benzodioxan; Immunosuppressive activity; Inducible NOS; Oxadiazole

Indexed keywords

1,4 BENZODIOXAN DERIVATIVE; 2 (2 CHLOROPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 TOLYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 METHOXYBENZYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3.4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (PHENOXYMETHYL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (PYRIDIN 3 YL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 PHENETHYL 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 PHENYL 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 STYRYL 1,3,4 OXADIAZOLE; 2 (4 BROMOPHENYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (4 CHLOROBENZYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (5 BROMOPYRIDIN 3 YL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 [(4 CHLOROPHENOXY)METHYL] 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 BENZYL 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 3 (3 CHLOROBENZYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4H PYRAZOLE; 3 (BROMOMETHYL) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4H PYRAZOLE; IMMUNOSUPPRESSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; IMMUNOSUPPRESSIVE ACTIVITY; MOLECULAR DOCKING; MOUSE; NONHUMAN; RAW264.7 CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; DIOXANES; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MACROPHAGES; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXADIAZOLES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79961166359     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.061     Document Type: Article

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