Receptor-Associated Protein Blocks Internalization and Cytotoxicity of Myeloma Light Chain in Cultured Human Proximal Tubular Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Sengul, Sule ^a   Erturk, Sehsuvar ^a   Khan, Altaf M ^b   Batuman, Vecihi ^b,c  

^a ANKARA UNIVERSITY   (Turkey)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CHAPERONE; CUBILIN; INTERLEUKIN 6; INTERLEUKIN 8; MEGALIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOMA LIGHT CHAIN; PARAPROTEIN; RECEPTOR ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; INTERNALIZATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MYELOMA; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BRAIN MAPPING; CASE-CONTROL STUDIES; CELL PHYSIOLOGICAL PHENOMENA; FEMALE; FLUORODEOXYGLUCOSE F18; FOLLOW-UP STUDIES; GLUCOSE; HUMANS; LONGITUDINAL STUDIES; MALE; MICE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEURAL NETWORKS (COMPUTER); NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY; RATS;

EID: 84880706062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070276     Document Type: Article

References (35)

1. Klassen RB, Allen PL, Batuman V, Crenshaw K, Hammond TG, (2005) Light chains are a ligand for megalin. Journal of applied physiology 98: 257-263.
2. Batuman V, Verroust PJ, Navar GL, Kaysen JH, Goda FO, et al. (1998) Myeloma light chains are ligands for cubilin (gp280). The American journal of physiology 275: F246-254.
3. Batuman V, Guan S, (1997) Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells. The American journal of physiology 272: F521-530.
4. Batuman V, Dreisbach AW, Cyran J, (1990) Light-chain binding sites on renal brush-border membranes. The American journal of physiology 258: F1259-1265.
5. Nakhoul N, Batuman V, (2011) Role of proximal tubules in the pathogenesis of kidney disease. Contributions to nephrology 169: 37-50.
6. Sengul S, Li M, Batuman V, (2009) Myeloma kidney: toward its prevention-with new insights from in vitro and in vivo models of renal injury. Journal of nephrology 22: 17-28.
7. Sengul S, Zwizinski C, Batuman V, (2003) Role of MAPK pathways in light chain-induced cytokine production in human proximal tubule cells. American journal of physiology Renal physiology 284: F1245-1254.
8. Ying WZ, Wang PX, Aaron KJ, Basnayake K, Sanders PW, (2011) Immunoglobulin light chains activate nuclear factor-kappaB in renal epithelial cells through a Src-dependent mechanism. Blood 117: 1301-1307.
9. Li M, Hering-Smith KS, Simon EE, Batuman V, (2008) Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association- European Renal Association 23: 860-870.
10. Hutchison CA, Batuman V, Behrens J, Bridoux F, Sirac C, et al. (2011) The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nature reviews Nephrology 8: 43-51.
11. Khan AM, Li M, Balamuthusamy S, Maderdrut JL, Simon EE, et al. (2010) Myeloma light chain-induced renal injury in mice. Nephron Experimental nephrology 116: e32-41.
12. Batuman V, (2007) Proximal tubular injury in myeloma. Contributions to nephrology 153: 87-104.
13. Sengul S, Zwizinski C, Simon EE, Kapasi A, Singhal PC, et al. (2002) Endocytosis of light chains induces cytokines through activation of NF-kappaB in human proximal tubule cells. Kidney international 62: 1977-1988.
14. Pote A, Zwizinski C, Simon EE, Meleg-Smith S, Batuman V, (2000) Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells. American journal of kidney diseases: the official journal of the National Kidney Foundation 36: 735-744.
15. Guan S, el-Dahr S, Dipp S, Batuman V, (1999) Inhibition of Na-K-ATPase activity and gene expression by a myeloma light chain in proximal tubule cells. Journal of investigative medicine: the official publication of the American Federation for Clinical Research 47: 496-501.
16. Batuman V, (2012) The pathogenesis of acute kidney impairment in patients with multiple myeloma. Advances in chronic kidney disease 19: 282-286.
17. Verroust PJ, Birn H, Nielsen R, Kozyraki R, Christensen EI, (2002) The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology. Kidney Int 62: 745-756.
18. Sarti M, Farquhar MG, Orlando RA, (2000) The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin. Exp Cell Res 260: 199-207.
19. Birn H, Vorum H, Verroust PJ, Moestrup SK, Christensen EI, (2000) Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. J Am Soc Nephrol 11: 191-202.
20. Wolff NA, Abouhamed M, Verroust PJ, Thevenod F, (2006) Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. J Pharmacol Exp Ther 318: 782-791.
21. Diwakar R, Pearson AL, Colville-Nash P, Brunskill NJ, Dockrell ME, (2007) The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells. Am J Physiol Renal Physiol 292: F1464-1470.
22. Kolman P, Pica A, Carvou N, Boyde A, Cockcroft S, et al. (2009) Insulin uptake across the luminal membrane of the rat proximal tubule in vivo and in vitro. Am J Physiol Renal Physiol 296: F1227-1237.
23. Li M, Balamuthusamy S, Simon EE, Batuman V, (2008) Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells. American journal of physiology Renal physiology 295: F82-90.
24. Willnow TE, (1998) Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors. Biol Chem 379: 1025-1031.
25. Willnow TE, Rohlmann A, Horton J, Otani H, Braun JR, et al. (1996) RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. The EMBO journal 15: 2632-2639.
26. Bu G, (2001) The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family. Int Rev Cytol 209: 79-116.
27. Czekay RP, Orlando RA, Woodward L, Lundstrom M, Farquhar MG, (1997) Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. Mol Biol Cell 8: 517-532.
28. Zhai XY, Nielsen R, Birn H, Drumm K, Mildenberger S, et al. (2000) Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 58: 1523-1533.
29. Onodera A, Tani M, Michigami T, Yamagata M, Min KS, et al. (2012) Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo. Toxicol Lett 212: 91-96.
30. Prabakaran T, Nielsen R, Satchell SC, Mathieson PW, Feldt-Rasmussen U, et al. (2012) Mannose 6-phosphate receptor and sortilin mediated endocytosis of alpha-galactosidase A in kidney endothelial cells. PLoS One 7: e39975.
31. Benigni A, Remuzzi G, (2001) How renal cytokines and growth factors contribute to renal disease progression. Am J Kidney Dis 37: S21-24.
32. Benigni A, Remuzzi G (1998) Mechanism of progression of renal disease: growth factors and related mechanisms. J Hypertens Suppl 16: S9-12.
33. Abbate M, Zoja C, Corna D, Capitanio M, Bertani T, et al. (1998) In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J Am Soc Nephrol 9: 1213-1224.
34. Morigi M, Macconi D, Zoja C, Donadelli R, Buelli S, et al. (2002) Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol 13: 1179-1189.
35. Hutchison CA, Cockwell P, Harding S, Mead GP, Bradwell AR, et al. (2008) Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease? Expert Opin Ther Targets 12: 667-676.