Protein overload-induced NF-κB activation in proximal tubular cells requires H2O2 through a PKC-dependent pathway

Journal of the American Society of Nephrology

Volumn 13, Issue 5, 2002, Pages 1179-1189

  Morigi, Marina ^a   Macconi, Daniela ^a   Zoja, Carla ^a   Donadelli, Roberta ^a   Buelli, Simona ^a   Zanchi, Cristina ^a   Ghilardi, Marina ^a   Remuzzi, Giuseppe ^a  

^a MARIO NEGRI INST PHARMACOL RES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ANTIOXIDANT; CALPHOSTIN; DIMETHYLTHIOUREA; DIPHENYLIODONIUM SALT; HUMAN ALBUMIN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; HUMAN; HUMAN CELL; KIDNEY DYSFUNCTION; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL RESPIRATION; NEPHRITIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN TRANSPORT; SECOND MESSENGER;

EID: 0036235016     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Pathophysiology of progressive nephropathies
2. Proteinuria as a mediator of tubulointerstitial injury
3. Interstitial nephritis induced by protein overload proteinuria
4. In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation
5. Protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators
6. Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein
7. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation
8. NF-kB to the rescue. RELs, apoptosis and cellular transformation
9. Signal transduction through NF-kB
10. The transcription factor NF-kB and human disease
11. Antioxidant and redox regulation of gene transcription
12. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1
13. Study of gene regulation by NF-kB and AP-1 in response to reactive oxygen intermediates
14. Nuclear factor kB: An oxidative stress-responsive transcription factor of eukaryotic cells
15. E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-kB activation
16. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kB activation induced by intracellular oxidative stress
17. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B
18. Inhibition of IkB-α phosphorylation and degradation and subsequent NF-kB activation by glutathione peroxidase overexpression
19. 1 cells: Role of free radicals
20. 2-isoprostane production and injury in renal tubular epithelial cells
21. Reactive oxygen species and rat renal epithelial cells during hypoxia and reoxygenation
22. HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney
23. Dithiocarbamates as potent inhibitors of nuclear factor kB activation in intact cells
24. Hydrogen peroxide causes dimethylthiourea consumption while hydroxyl radical causes dimethylsulfoxide consumption in vitro
25. 1 cells: A role for iron
26. Protein kinase C regulates cytokineinduced tissue factor transcription and procoagulant activity in human endothelial cells
27. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
28. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
29. The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase
30. Hepatic microsomal ethanol oxidation
31. Expression of the M-CSF (CSF-1) gene by human monocytes
32. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
33. Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription
34. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
35. Angiotensin II induces superoxide anion production by mesangial cells
36. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kB in proximal tubule cells
37. Transcription factor NF-kB in glomerulonephritis
38. Protein traffic activates NF-kB gene signaling and promotes MCP-1-dependent interstitial inflammation
39. 2+ and reactive oxygen intermediates as messengers
40. Protein kinase C isozymes and the regulation of diverse cell responses
41. Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals
42. Interactions between the components of the human NADPH oxidase: Intrigues in the phox family
43. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
44. Megalin/gp330 mediates uptake of albumin in renal proximal tubule
45. Characterization and localization of the neonatal Fc receptor in adult human kidney
46. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
47. Impairment of the mitochondrial electron chain transport prevents NF-kB activation by hydrogen peroxide
48. Superoxide production by the mitochondrial respiratory chain