Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules

Journal of the American Society of Nephrology

Volumn 11, Issue 2, 2000, Pages 191-202

  Birn, Henrik ^b   Vorum, Henrik ^c   Verroust, Pierre J ^a   Moestrup, Søren K ^c   Christensen, Erik Ilsø ^c  

^a Urgences Néphrologiques et Transplantation Rénale Hôpital Tenon 4   (France)

^b AARHUS UNIVERSITY   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; MEGALIN;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION;

EID: 0033968875     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Pietromonaco S, Kerjaschki D, Binder S, Ullrich R, Farquhar MG: Molecular cloning of a cDNA encoding a major pathogenic domain of the Heymann nephritis antigen gp330. Proc Natl Acad Sci USA 87: 1811-1815, 1990
2. Furukawa T, Ozawa M, Huang RP, Muramatsu T: A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem (Tokyo) 108: 297-302, 1990
3. Strickland DK, Ashcom JD, Williams S, Battey F, Behre E, McTigue K, Battey JF, Argraves WS: Primary structure of alpha 2-macroglobulin receptor-associated protein: Human homologue of a Heymann nephritis antigen. J Biol Chem 266: 13364-13369, 1991
4. Moestrup SK, Gliemann J: Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein): Evidence that high affinity of alpha 2-macroglobulin- proteinase complex is achieved by binding to adjacent receptors. J Biol Chem 266: 14011-14017, 1991
5. Ashcom JD, Tiller SE, Dickerson K, Cravens JL, Argraves WS, Strickland DK: The human alpha 2-macroglobulin receptor: Identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin. J Cell Biol 110: 1041-1048, 1990
6. Jensen PH, Moestrup SK, Gliemann J: Purification of the human placental alpha 2-macroglobulin receptor. FEBS Lett 255: 275-280, 1989
7. Battey FD, Gafvels ME, FitzGerald DJ, Argraves WS, Chappell DA, Strauss JF III, Strickland DK: The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem 269: 23268-23273, 1994
8. Christensen EI, Gliemann J, Moestrup SK: Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J Histochem Cytochem 40: 1481-1490, 1992
9. Orlando RA, Kerjaschki D, Kurihara H, Biemesderfer D, Farquhar MG: gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Natl Acad Sci USA 89: 6698-6702, 1992
10. 12 homeostasis. Proc Natl Acad Sci USA 93: 8612-8617, 1996
11. Moestrup SK: The alpha 2-macroglobulin receptor and epithelial glycoprotein- 330: Two giant receptors mediating endocytosis of multiple ligands. Biochim Biophys Acta 1197: 197-213, 1994
12. Bu G, Geuze HJ, Strous GJ, Schwartz AL: 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J 14: 2269-2280, 1995
13. 2-MRAP is modified by tissue processing. Eur J Cell Biol 61: 139-149, 1993
14. Willnow TE, Armstrong SA, Hammer RE, Herz J: Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci USA 92: 4537-4541, 1995
15. Bu G, Rennke S: Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 271: 22218-22224, 1996
16. Willnow TE, Rohlmann A, Horton J, Otani H, Braun JR, Hammer RE, Herz J: RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J 15: 2632-2639, 1996
17. Willnow TE: Receptor-associated protein (RAP): A specialized chaperone for endocytic receptors. Biol Chem 379: 1025-1031, 1998
18. Saito A, Pietromonaco S, Loo AK, Farquhar MG: Complete cloning and sequencing of rat gp330/"megalin,"a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 91: 9725-9729, 1994
19. Kerjaschki D, Farquhar MG: The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79: 5557-5581, 1982
20. Christensen EI, Nielsen S, Moestrup SK, Borre C, Maunsbach AB, de Heer E, Ronco P, Hammond TG, Verroust P: Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur J Cell Biol 66: 349-364, 1995
21. Kerjaschki D, Horvat R, Binder S, Susani M, Dekan G, Ojha PP, Hillemanns P, Ulrich W, Donini U: Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am J Pathol 129: 183-191, 1987
22. Makker SP, Singh AK: Characterization of the antigen (gp600) of Heymann nephritis. Lab Invest 50: 287-293, 1984
23. Christensen EI, Birn H, Verroust P, Moestrup SK: Membrane receptors for endocytosis in the renal proximal tubule. Int Rev Cytol 180: 237-284, 1998
24. Gliemann J: Receptors of the low density lipoprotein (LDL) receptor family in man: Multiple functions of the large members via interaction with complex ligands. Biol Chem 379: 951-964, 1998
25. Moestrup SK, Nielsen S, Andreasen P, Jørgensen KE, Nykjær A, Roigaard H, Gliemann J, Christensen EI: Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem 268: 16564-16570, 1993
26. Willnow TE, Goldstein JL, Orth K, Brown MS, Herz J: Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem 267: 26172-26180, 1992
27. Stefansson S, Kounnas MZ, Henkin J, Mallampalli RK, Chappell DA, Strickland DK, Argraves WS: gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex. J Cell Sci 108: 2361-2368, 1995
28. Kounnas MZ, Chappell DA, Strickland DK, Argraves WS: Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. J Biol Chem 268: 14176-14181, 1993
29. Kounnas MZ, Loukinova EB, Stefansson S, Harmony JA, Brewer BH, Strickland DK, Argraves WS: Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J Biol Chem 270: 13070-13075, 1995
30. Stefansson S, Chappell DA, Argraves KM, Strickland DK, Argraves WS: Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. J Biol Chem 270: 19417-19421, 1995
31. Moestrup SK, Schousboe I, Jacobsen C, Leheste JR, Christensen EI, Willnow TE: Beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin. J Clin Invest 102: 902-909, 1998
32. Moestrup SK, Cui S, Vorum H, Bregengard C, Bjorn SE, Norris K, Gliemann J, Christensen EI: Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest 96: 1404-1413, 1995
33. Kanalas JJ, Makker SP: Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen. J Biol Chem 266: 10825-10829, 1991
34. Cui S, Verroust PJ, Moestrup SK, Christensen EI: Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol 271: F900-F907, 1996
35. 3. Cell 96: 507-515, 1999
36. Christensen EI, Moskaug JO, Vorum H, Jacobsen C, Gundersen TE, Nykjaer A, Blomhoff R, Willnow TE, Moestrup SK: Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol 10: 685-695, 1999
37. Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, Farquhar MG: Megalin is an endocytic receptor for insulin. J Am Soc Nephrol 9: 1759-1766, 1998
38. Bachinsky DR, Zheng G, Niles JL, McLaughlin M, Abbate M, Andres G, Brown D, McCluskey RT: Detection of two forms of GP330: Their role in Heymann nephritis. Am J Pathol 143: 598-611, 1993
39. Chatelet F, Brianti E, Ronco P, Roland J, Verroust P: Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution. Am J Pathol 122: 500-511, 1986
40. Marples D, Knepper MA, Christensen EI, Nielsen S: Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am J Physiol 269: C655-C664, 1995
41. Tencer J, Thysell H, Andersson K, Grubb A: Stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain immunoreactivity, orosomucoid and alpha 1-antitrypsin in urine stored at various conditions. Scand J Clin Lab Invest 54: 199-206, 1994
42. Lowry OH, Rosebrough N, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951
43. Nykjær A, Petersen CM, Møller B, Jensen PH, Moestrup SK, Holtet TL, Etzerodt M, Thøgersen HC, Munch M, Andreasen PA, Gliemann J: Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase:plasminogen activator inhibitor type-1 complex: Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem 267: 14543-14546, 1992
44. Sahali D, Mulliez N, Chatelet F, Laurent Winter C, Citadelle D, Sabourin JC, Roux C, Ronco P, Verroust P: Comparative immunochemistry and ontogeny of two closely related coated pit proteins: The 280-kD target of teratogenic antibodies and the 330-kD target of nephritogenic antibodies. Am J Pathol 142: 1654-1667, 1993
45. Mandon B, Nielsen S, Kishore BK, Knepper MA: Expression of syntaxins in rat kidney. Am J Physiol 273: F718-F730, 1997
46. Shevchenko A, Wilm M, Vorm O, Mann M: Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858, 1996
47. Nielsen S, Smith BL, Christensen EI, Knepper MA, Agre P: CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol 120: 371-383, 1993
48. Cui S, Flyvbjerg A, Nielsen S, Kiess W, Christensen EI: IGF-II/Man-6-P receptors in rat kidney: Apical localization in proximal tubule cells. Kidney Int 43: 796-807, 1993
49. Maunsbach AB, Christensen EI: Functional ultrastructure of the proximal tubule. In: Handbook of Physiology: Renal Physiology, edited by Windhager EE, New York, Oxford University Press, 1992, pp 41-107
50. Christensen EI, Nielsen S, Hellfritzsch M, Nielsen JT: Luminal uptake of insulin in renal proximal tubules. Contrib Nephrol 68: 78-85, 1988
51. Czekay RP, Orlando RA, Woodward L, Lundström M, Farquhar MG: Endocytic trafficking of megalin/RAP complexes: Dissociation of the complexes in late endosomes. Mol Biol Cell 8: 517-532, 1997
52. Kaye WA, Griffiths WC, Camara PD, Trebbin WM, Solomon RJ, Diamond I: The significance of beta-2 microglobulinuria associated with gentamicin therapy. Ann Clin Lab Sci 11: 530-537, 1981
53. Junge W, Malyusz M, Ehrens HJ: The role of the kidney in the elimination of pancreatic lipase and amylase from blood. J Clin Chem Clin Biochem 23: 387-392, 1985
54. Willnow TE, Hilpert J, Armstrong SA, Rohlmann A, Hammer RE, Burns DK, Herz J: Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 93: 8460-8464, 1996