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Volumn 62, Issue 3, 2002, Pages 745-756

The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology

Author keywords

DBP; Endocytosis; Fanconi syndrome; Imerlund Gr sbeck syndrome; LDL receptor family; RAP

Indexed keywords

ALBUMIN; AMIKACIN; AMINOGLYCOSIDE; APOLIPOPROTEIN; APROTININ; CALCIUM ION; CUBILIN; CYANOCOBALAMIN; ENZYME; ENZYME INHIBITOR; GENTAMICIN; HEMOGLOBIN; HORMONE; IMMUNOGLOBULIN LIGHT CHAIN; LACTOFERRIN; LIGAND; MEGALIN; NETILMICIN; PLASMINOGEN; PROTEIN; RAP PROTEIN; RETINOL; TRICHOSANTHIN; VITAMIN BINDING PROTEIN;

EID: 0036426804     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00501.x     Document Type: Article
Times cited : (131)

References (125)
  • 1
    • 0023091262 scopus 로고
    • Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
    • Davis CG, Goldstein JL, Sudhof TC, et al: Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature 326:760-765, 1987
    • (1987) Nature , vol.326 , pp. 760-765
    • Davis, C.G.1    Goldstein, J.L.2    Sudhof, T.C.3
  • 2
    • 0028019068 scopus 로고
    • Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family
    • Saito A, Pietromonaco S, Loo AK, et al: Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 91:9725-9729, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9725-9729
    • Saito, A.1    Pietromonaco, S.2    Loo, A.K.3
  • 3
    • 0039516463 scopus 로고    scopus 로고
    • +)-binding receptor with potential intracellular signaling properties
    • +)-binding receptor with potential intracellular signaling properties. Eur J Biochem 239:132-137, 1996
    • (1996) Eur J Biochem , vol.239 , pp. 132-137
    • Hjalm, G.1    Murray, E.2    Crumley, G.3
  • 4
    • 0030898707 scopus 로고    scopus 로고
    • Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions
    • Orlando RA, Exner M, Czekay RP, et al: Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions. Proc Natl Acad Sci USA 94:2368-2373, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2368-2373
    • Orlando, R.A.1    Exner, M.2    Czekay, R.P.3
  • 5
    • 0032570583 scopus 로고    scopus 로고
    • 12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
    • 12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 273:5235-5242, 1998
    • (1998) J Biol Chem , vol.273 , pp. 5235-5242
    • Moestrup, S.K.1    Kozyraki, R.2    Kristiansen, M.3
  • 6
    • 0032525203 scopus 로고    scopus 로고
    • 12 receptor, cubilin: Molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region
    • 12 receptor, cubilin: Molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 91:3593-3600, 1998
    • (1998) Blood , vol.91 , pp. 3593-3600
    • Kozyraki, R.1    Kristiansen, M.2    Silahtaroglu, A.3
  • 7
    • 0033570972 scopus 로고    scopus 로고
    • Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption
    • Xu D, Kozyraki R, Newman TC, et al: Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. Blood 94: 3604-3606, 1999
    • (1999) Blood , vol.94 , pp. 3604-3606
    • Xu, D.1    Kozyraki, R.2    Newman, T.C.3
  • 8
    • 0034661941 scopus 로고    scopus 로고
    • Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin
    • Kristiansen M, Aminoff M, Jacobsen C, et al: Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin. Blood 96:405-409, 2000
    • (2000) Blood , vol.96 , pp. 405-409
    • Kristiansen, M.1    Aminoff, M.2    Jacobsen, C.3
  • 9
    • 0033575195 scopus 로고    scopus 로고
    • 12 receptor, cubilin, discloses regions important for membrane association and ligand binding
    • 12 receptor, cubilin, discloses regions important for membrane association and ligand binding. J Biol Chem 274:20540-20544, 1999
    • (1999) J Biol Chem , vol.274 , pp. 20540-20544
    • Kristiansen, M.1    Kozyraki, R.2    Jacobsen, C.3
  • 10
    • 0035977017 scopus 로고    scopus 로고
    • Identification and characterization of two distinct ligand binding regions of cubilin
    • Yammani RR, Seetharam S, Seetharam B: Identification and characterization of two distinct ligand binding regions of cubilin. J Biol Chem 276:44777-44784, 2001
    • (2001) J Biol Chem , vol.276 , pp. 44777-44784
    • Yammani, R.R.1    Seetharam, S.2    Seetharam, B.3
  • 11
    • 0034941332 scopus 로고    scopus 로고
    • Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
    • Moestrup SK, Verroust PJ: Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia. Annu Rev Nutr 21:407-428, 2001
    • (2001) Annu Rev Nutr , vol.21 , pp. 407-428
    • Moestrup, S.K.1    Verroust, P.J.2
  • 12
    • 0035195421 scopus 로고    scopus 로고
    • Cubilin and megalin expression and their interaction in the rat intestine: Effect of thyroidectomy
    • Yammani RR, Seetharam S, Seetharam B: Cubilin and megalin expression and their interaction in the rat intestine: Effect of thyroidectomy. Am J Physiol Endocrinol Metab 281:E900-E907, 2001
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E900-E907
    • Yammani, R.R.1    Seetharam, S.2    Seetharam, B.3
  • 13
    • 0033525746 scopus 로고    scopus 로고
    • 12 receptor, cubilin, is assembled into trimers via a coiled-coil alpha-helix
    • 12 receptor, cubilin, is assembled into trimers via a coiled-coil alpha-helix. J Biol Chem 274:6374-6380, 1999
    • (1999) J Biol Chem , vol.274 , pp. 6374-6380
    • Lindblom, A.1    Quadt, N.2    Marsh, T.3
  • 14
    • 0000063546 scopus 로고    scopus 로고
    • Lipoprotein receptors: New roles for ancient proteins
    • Willnow TE, nykjaer A, Herz J: Lipoprotein receptors: New roles for ancient proteins. Nat Cell Biol 1:E157-E162, 1999
    • (1999) Nat Cell Biol , vol.1 , pp. E157-E162
    • Willnow, T.E.1    Nykjaer, A.2    Herz, J.3
  • 15
    • 0004846480 scopus 로고
    • The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border
    • Kerjaschki D, Farquhar MG: The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557-5581, 1982
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 5557-5581
    • Kerjaschki, D.1    Farquhar, M.G.2
  • 16
    • 0020664191 scopus 로고
    • Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats
    • Kerjaschki D, Farquhar MG: Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667-686, 1983
    • (1983) J Exp Med , vol.157 , pp. 667-686
    • Kerjaschki, D.1    Farquhar, M.G.2
  • 17
    • 0028932828 scopus 로고
    • Segmental distribution of the endocytosis receptor gp 330 in renal proximal tubules
    • Christensen EI, Niemlsen S, Moestrup SK, et al: Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur J Cell Biol 66:349-364, 1995
    • (1995) Eur J Cell Biol , vol.66 , pp. 349-364
    • Christensen, E.I.1    Niemlsen, S.2    Moestrup, S.K.3
  • 18
    • 0031889953 scopus 로고    scopus 로고
    • Membrane receptors for endocytosis in the renal proximal tubule
    • Christensen EI, Birn H, Verroust P, et al: Membrane receptors for endocytosis in the renal proximal tubule. Int Rev Cytol 180: 237-84:237-284, 1998
    • (1998) Int Rev Cytol , vol.180 , pp. 237-284
    • Christensen, E.I.1    Birn, H.2    Verroust, P.3
  • 19
    • 0023948431 scopus 로고
    • Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies
    • Sahali D, Mulliez N, Chatelet F, et al: Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies. J Exp Med 167:213-218, 1988
    • (1988) J Exp Med , vol.167 , pp. 213-218
    • Sahali, D.1    Mulliez, N.2    Chatelet, F.3
  • 21
    • 0021350826 scopus 로고
    • Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dogileum: Distribution of intracellular receptor during cell maturation
    • Levine JS, Allen RH, Alpers DH, et al: Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dogileum: Distribution of intracellular receptor during cell maturation. J Cell Biol 98:1111-1118, 1984
    • (1984) J Cell Biol , vol.98 , pp. 1111-1118
    • Levine, J.S.1    Allen, R.H.2    Alpers, D.H.3
  • 22
    • 0034697043 scopus 로고    scopus 로고
    • Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
    • Hammad SM, Birth JL, Knaak C, et al: Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem 275:12003-12008, 2000
    • (2000) J Biol Chem , vol.275 , pp. 12003-12008
    • Hammad, S.M.1    Birth, J.L.2    Knaak, C.3
  • 23
    • 0028324029 scopus 로고
    • Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP)
    • Zheng G, Bachinsky DR, Stamenkovic I, et al: Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 42:531-542, 1994
    • (1994) J Histochem Cytochem , vol.42 , pp. 531-542
    • Zheng, G.1    Bachinsky, D.R.2    Stamenkovic, I.3
  • 25
    • 0033968875 scopus 로고    scopus 로고
    • Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules
    • Birn H, Vorum H, Verroust PJ, et al: Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. J Am Soc Nephrol 11:191-202, 2000
    • (2000) J Am Soc Nephrol , vol.11 , pp. 191-202
    • Birn, H.1    Vorum, H.2    Verroust, P.J.3
  • 26
    • 0028988551 scopus 로고
    • 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
    • Bu G, Geuze HJ, Strous GJ, et al: 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J 14:2269-2280, 1995
    • (1995) EMBO J , vol.14 , pp. 2269-2280
    • Bu, G.1    Geuze, H.J.2    Strous, G.J.3
  • 27
    • 0029786288 scopus 로고    scopus 로고
    • Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein
    • Bu G, Rennke S: Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 271:22218-22224, 1996
    • (1996) J Biol Chem , vol.271 , pp. 22218-22224
    • Bu, G.1    Rennke, S.2
  • 28
    • 0029079403 scopus 로고
    • Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo
    • Willnow TE, Armstrong SA, Hammer RE, et al: Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci USA 92:4537-4541, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4537-4541
    • Willnow, T.E.1    Armstrong, S.A.2    Hammer, R.E.3
  • 29
    • 0029887302 scopus 로고    scopus 로고
    • RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
    • Willnow TE, Rohlmann A, Horton J, et al: RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J 15: 2632-2639, 1996
    • (1996) EMBO J , vol.15 , pp. 2632-2639
    • Willnow, T.E.1    Rohlmann, A.2    Horton, J.3
  • 30
    • 0031662589 scopus 로고    scopus 로고
    • Receptor-associated protein (RAP): A specialized chaperone for endocytic receptors
    • Willnow TE: Receptor-associated protein (RAP): A specialized chaperone for endocytic receptors. Biol Chem 379:1025-1031, 1998
    • (1998) Biol Chem , vol.379 , pp. 1025-1031
    • Willnow, T.E.1
  • 31
    • 0035940434 scopus 로고    scopus 로고
    • Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
    • Kozymaki R, Fyfe J, Verroust PJ, et al: Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci USA 98: 12491-12496, 2001
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12491-12496
    • Kozymraki, R.1    Fyfe, J.2    Verroust, P.J.3
  • 32
    • 0033056072 scopus 로고    scopus 로고
    • 12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    • 12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 5:656-661, 1999
    • (1999) Nat Med , vol.5 , pp. 656-661
    • Kozyraki, R.1    Fyfe, J.2    Kristiansen, M.3
  • 33
    • 0035918187 scopus 로고    scopus 로고
    • A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney
    • Burmeister R, Boe IM, Nykjaer A, et al: A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. J Biol Chem 276:13295-13301, 2001
    • (2001) J Biol Chem , vol.276 , pp. 13295-13301
    • Burmeister, R.1    Boe, I.M.2    Nykjaer, A.3
  • 35
    • 0034073250 scopus 로고    scopus 로고
    • Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
    • Birn H, Fyfe JC, Jacobsen C, et al: Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 105:1353-1361, 2000
    • (2000) J Clin Invest , vol.105 , pp. 1353-1361
    • Birn, H.1    Fyfe, J.C.2    Jacobsen, C.3
  • 37
    • 0030988207 scopus 로고    scopus 로고
    • Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor
    • Seetharam B, Christensen EI, Moestrup SK, et al: Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. J Clin Invest 99: 2317-2322, 1997
    • (1997) J Clin Invest , vol.99 , pp. 2317-2322
    • Seetharam, B.1    Christensen, E.I.2    Moestrup, S.K.3
  • 39
    • 0033025413 scopus 로고    scopus 로고
    • Evidence for an essential role of megalin in transepithelial transport of retinol
    • Christensen EI, Moskaug JO, Vorum H, et al: Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol 10:685-695, 1999
    • (1999) J Am Soc Nephrol , vol.10 , pp. 685-695
    • Christensen, E.I.1    Moskaug, J.O.2    Vorum, H.3
  • 40
    • 0029144022 scopus 로고
    • Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100
    • Stefansson S, Chapell DA, Argraves KM, et al: Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. J Biol Chem 270:19417-19421, 1995
    • (1995) J Biol Chem , vol.270 , pp. 19417-19421
    • Stefansson, S.1    Chappell, D.A.2    Argraves, K.M.3
  • 41
    • 0027079937 scopus 로고
    • Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance
    • Willnow TE, Goldstein JL, Orth K, et al: Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem 267:26172-26180, 1992
    • (1992) J Biol Chem , vol.267 , pp. 26172-26180
    • Willnow, T.E.1    Goldstein, J.L.2    Orth, K.3
  • 42
    • 0033621106 scopus 로고    scopus 로고
    • Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis
    • Hammad SM, Stefansson S, Twal WO, et al: Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis. Proc Natl Acad Sci USA 96:10158-10163, 1999
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10158-10163
    • Hammad, S.M.1    Stefansson, S.2    Twal, W.O.3
  • 43
    • 0029018581 scopus 로고
    • Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin
    • Kounnas MZ, Loukinova EB, Stefansson S, et al: Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J Biol Chem 270:13070-13075, 1995
    • (1995) J Biol Chem , vol.270 , pp. 13070-13075
    • Kounnas, M.Z.1    Loukinova, E.B.2    Stefansson, S.3
  • 44
    • 0032148360 scopus 로고    scopus 로고
    • β2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
    • Moestrup SK, Schousboe I, Jacobsen C, et al: β2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin. J Clin Invest 102:902-909, 1998
    • (1998) J Clin Invest , vol.102 , pp. 902-909
    • Moestrup, S.K.1    Schousboe, I.2    Jacobsen, C.3
  • 45
    • 0033605263 scopus 로고    scopus 로고
    • Megalin antagonizes activation of the parathyroid hormone receptor
    • Hilpert J, Nykjær A, Jacobsen C, et al: Megalin antagonizes activation of the parathyroid hormone receptor. J Biol Chem 274: 5620-5625, 1999
    • (1999) J Biol Chem , vol.274 , pp. 5620-5625
    • Hilpert, J.1    Nykjær, A.2    Jacobsen, C.3
  • 46
    • 0031718488 scopus 로고    scopus 로고
    • Megalin is an endocytic receptor for insulin
    • Orlando RA, Rader K, Authier F, et al: Megalin is an endocytic receptor for insulin. J Am Soc Nephrol 9:1759-1766, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1759-1766
    • Orlando, R.A.1    Rader, K.2    Authier, F.3
  • 47
    • 0032857025 scopus 로고    scopus 로고
    • Megalin knockout mice as an animal model of low molecular weight proteinuria
    • Leheste JR, Rolinski B, Vorum H, et al: Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 155:1361-1370, 1999
    • (1999) Am J Pathol , vol.155 , pp. 1361-1370
    • Leheste, J.R.1    Rolinski, B.2    Vorum, H.3
  • 48
    • 0034624105 scopus 로고    scopus 로고
    • Evidence for the role of megalin in renal uptake of transthyretin
    • Sousa MM, Norden AG, Jacobsen C, et al: Evidence for the role of megalin in renal uptake of transthyretin. J Biol Chem 275: 38176-38181, 2000
    • (2000) J Biol Chem , vol.275 , pp. 38176-38181
    • Sousa, M.M.1    Norden, A.G.2    Jacobsen, C.3
  • 49
    • 0029908225 scopus 로고    scopus 로고
    • Megalin/gp 330 mediates uptake of albumin in renal proximal tubule
    • Cui S, Verroust PJ, Moestrup SK, et al: Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol 271: F900-F907, 1996
    • (1996) Am J Physiol , vol.271 , pp. F900-F907
    • Cui, S.1    Verroust, P.J.2    Moestrup, S.K.3
  • 50
    • 0026722478 scopus 로고
    • Renal tubule gp 330 is a calcium binding receptor for endocytic uptake of protein
    • Christensen EI, Gliemmann J, Moestrup SK: Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J Histochem Cytochem 40:1481-1490, 1992
    • (1992) J Histochem Cytochem , vol.40 , pp. 1481-1490
    • Christensen, E.I.1    Gliemmann, J.2    Moestrup, S.K.3
  • 51
    • 0027401997 scopus 로고
    • Analysis of a 45-kDa protein that binds to the Heymann nephritis autoantigen GP330
    • Kanalas JJ, Makker SP: Analysis of a 45-kDa protein that binds to the Heymann nephritis autoantigen GP330. J Biol Chem 268: 8188-8192, 1993
    • (1993) J Biol Chem , vol.268 , pp. 8188-8192
    • Kanalas, J.J.1    Makker, S.P.2
  • 52
    • 0026662463 scopus 로고
    • The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    • Kounnas MZ, Argraves WS, Strickland DK: The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J Biol Chem 267:21162-21166, 1992
    • (1992) J Biol Chem , vol.267 , pp. 21162-21166
    • Kounnas, M.Z.1    Argraves, W.S.2    Strickland, D.K.3
  • 53
    • 0026780531 scopus 로고
    • gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex
    • Orlando RA, Kerjaschki D, kurihara H, et al: gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Natl Acad Sci USA 89:6698-6702, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6698-6702
    • Orlando, R.A.1    Kerjaschki, D.2    Kurihara, H.3
  • 54
    • 0011286095 scopus 로고    scopus 로고
    • Receptor mediated uptake of light chains in kidney proximal tubules
    • edited by Aucouturier P, Hermine P, Ronco P, et al, Amsterdam, Boston, Klüwer Academic Publishers
    • Birn H, Lebeolleux M, Moestrup SK, et al: Receptor mediated uptake of light chains in kidney proximal tubules, in Monoclonal Gammapathies and the Kidney, edited by Aucouturier P, Hermine P, Ronco P, et al, Amsterdam, Boston, Klüwer Academic Publishers, 2002
    • (2002) Monoclonal Gammapathies and the Kidney
    • Birn, H.1    Lebeolleux, M.2    Moestrup, S.K.3
  • 55
    • 17344373956 scopus 로고    scopus 로고
    • Myeloma light chains are ligands for cubilin (gp280)
    • Batuman V, Verroust P J, Navar GL, et al: Myeloma light chains are ligands for cubilin (gp280). Am J Physiol 1275:F246-F254, 1998
    • (1998) Am J Physiol , vol.1275 , pp. F246-F254
    • Batuman, V.1    Verroust, P.J.2    Navar, G.L.3
  • 56
    • 0036155055 scopus 로고    scopus 로고
    • Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin
    • Gburek J, Verroust P J, Willnow TE, et al: Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol 13:423-430, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 423-430
    • Gburek, J.1    Verroust, P.J.2    Willnow, T.E.3
  • 57
    • 0025833080 scopus 로고
    • Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen
    • Kanalas JJ, Makker SP: Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen. J Biol Chem 266:10825-10829, 1991
    • (1991) J Biol Chem , vol.266 , pp. 10825-10829
    • Kanalas, J.J.1    Makker, S.P.2
  • 58
    • 0031738614 scopus 로고    scopus 로고
    • Megalin (gp330): A putative endocytic receptor for thyroglobulin (Tg)
    • Zheng G, Marino M, Zhao J, et al: Megalin (gp330): A putative endocytic receptor for thyroglobulin (Tg). Endocrinology 139: 1462-1465, 1998
    • (1998) Endocrinology , vol.139 , pp. 1462-1465
    • Zheng, G.1    Marino, M.2    Zhao, J.3
  • 59
    • 0029151692 scopus 로고
    • Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs
    • Moestrup SK, Cui S, Vorum H, et al: Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest 96:1404-1413, 1995
    • (1995) J Clin Invest , vol.96 , pp. 1404-1413
    • Moestrup, S.K.1    Cui, S.2    Vorum, H.3
  • 60
    • 0034643270 scopus 로고    scopus 로고
    • Trichosanthin interacts with and enters cells via LDL receptor family members
    • Chan WL, Shaw PC, Tam SC, et al: Trichosanthin interacts with and enters cells via LDL receptor family members. Biochem Biophys Res Commun 270:453-457, 2000
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 453-457
    • Chan, W.L.1    Shaw, P.C.2    Tam, S.C.3
  • 61
    • 0028998813 scopus 로고
    • gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinaseplasminogen activator inhibitor-1 complex
    • Stefansson S, Kounnas MZ, Henkin J, et al: gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinaseplasminogen activator inhibitor-1 complex. J Cell Sci 108:23612368, 1995
    • (1995) J Cell Sci , vol.108 , pp. 2361-2368
    • Stefansson, S.1    Kounnas, M.Z.2    Henkin, J.3
  • 62
    • 0027275370 scopus 로고
    • Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type- 1 complexes
    • Moestrup SK, Nielsen S, Andreasen P, et al: Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem 268:16564-16570, 1993
    • (1993) J Biol Chem , vol.268 , pp. 16564-16570
    • Moestrup, S.K.1    Nielsen, S.2    Andreasen, P.3
  • 63
    • 0027212194 scopus 로고
    • Glyco-protein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro
    • Kounnas MZ, Chappell DA, Strickland DK, et al: Glyco-protein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. J Biol Chem 268:14176-14181, 1993
    • (1993) J Biol Chem , vol.268 , pp. 14176-14181
    • Kounnas, M.Z.1    Chappell, D.A.2    Strickland, D.K.3
  • 64
    • 0029775625 scopus 로고    scopus 로고
    • Defective forebrain development in mice lacking gp330/megalin
    • Willnow TE, Hilpert J, Armstrong SA, et al: Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 93:8460-8464, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8460-8464
    • Willnow, T.E.1    Hilpert, J.2    Armstrong, S.A.3
  • 65
    • 0032828613 scopus 로고    scopus 로고
    • Essential role of megalin in renal proximal tubule for vitamin homeostasis
    • Christensen EI, Willnow TE: Essential role of megalin in renal proximal tubule for vitamin homeostasis. J Am Soc Nephrol 10: 2224-2236, 1999
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2224-2236
    • Christensen, E.I.1    Willnow, T.E.2
  • 66
    • 0036080704 scopus 로고    scopus 로고
    • Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12)
    • Birn H, Willnow TE, Nielsen R, et al: Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12). Am J Physiol (Renal Physiol) 282:F408-F416, 2002
    • (2002) Am J Physiol (Renal Physiol) , vol.282 , pp. F408-F416
    • Birn, H.1    Willnow, T.E.2    Nielsen, R.3
  • 67
    • 0035127319 scopus 로고    scopus 로고
    • Holoprosencephaly and low molecular weight proteinuria: The human homologue of murine megalin deficiency
    • Muller D, Ankermann T, Stephani U, et al: Holoprosencephaly and low molecular weight proteinuria: The human homologue of murine megalin deficiency. Am J Kidney Dis 37:624-628, 2001
    • (2001) Am J Kidney Dis , vol.37 , pp. 624-628
    • Muller, D.1    Ankermann, T.2    Stephani, U.3
  • 68
    • 72849184034 scopus 로고
    • Idiopathic chronic megaloblastic anemia in children
    • Imerslund O: Idiopathic chronic megaloblastic anemia in children. Acta Paediatr Scand 49:1-115, 1960
    • (1960) Acta Paediatr Scand , vol.49 , pp. 1-115
    • Imerslund, O.1
  • 69
    • 0021288620 scopus 로고
    • Imerslund-Grasbeck anemia. A long-term follow-up study
    • Broch H, Imerslund O, Monn E, et al: Imerslund-Grasbeck anemia. A long-term follow-up study. Acta Paediatr Scand 73:248-253, 1984
    • (1984) Acta Paediatr Scand , vol.73 , pp. 248-253
    • Broch, H.1    Imerslund, O.2    Monn, E.3
  • 71
    • 0033051889 scopus 로고    scopus 로고
    • 12 receptor, cubilin, cause hereditary megaloblastic anaemia 1
    • Aminoff M, Carter JE, Chadwick RB, et al: Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1. Nat Genet 21:309-313, 1999
    • (1999) Nat Genet , vol.21 , pp. 309-313
    • Aminoff, M.1    Carter, J.E.2    Chadwick, R.B.3
  • 72
    • 0025865890 scopus 로고
    • Defective brushborder expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption
    • Fyfe JC, Ramanujam KS, Ramaswamy K, et al: Defective brushborder expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption. J Biol Chem 266: 4489-4494, 1991
    • (1991) J Biol Chem , vol.266 , pp. 4489-4494
    • Fyfe, J.C.1    Ramanujam, K.S.2    Ramaswamy, K.3
  • 73
    • 0026068730 scopus 로고
    • Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs
    • Fyfe JC, Giger U, Hall CA, et al: Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs. Pediatr Res 29:24-31, 1991
    • (1991) Pediatr Res , vol.29 , pp. 24-31
    • Fyfe, J.C.1    Giger, U.2    Hall, C.A.3
  • 74
    • 0035155949 scopus 로고    scopus 로고
    • How renal cytokines and growth factors contribute to renal disease progression
    • Benigni A, Remuzzi G: How renal cytokines and growth factors contribute to renal disease progression. Am J Kidney Dis 37(Suppl): S21-S24, 2001
    • (2001) Am J Kidney Dis , vol.37 , pp. S21-S24
    • Benigni, A.1    Remuzzi, G.2
  • 75
    • 0034048667 scopus 로고    scopus 로고
    • The role of protein traffic in the progression of renal diseases
    • Ruggenenti P, Remuzzi G: The role of protein traffic in the progression of renal diseases. Annu Rev Med 51:315-327, 2000
    • (2000) Annu Rev Med , vol.51 , pp. 315-327
    • Ruggenenti, P.1    Remuzzi, G.2
  • 76
    • 0035252879 scopus 로고    scopus 로고
    • The LDL receptor gene family: Signaling functions during development
    • Howell BW, Herz J: The LDL receptor gene family: Signaling functions during development. Curr Opin Neurobiol 11:74-81, 2001
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 74-81
    • Howell, B.W.1    Herz, J.2
  • 77
    • 0035046073 scopus 로고    scopus 로고
    • The LDL receptor gene family: (Un)expected signal transducers in the brain
    • Herz J: The LDL receptor gene family: (Un)expected signal transducers in the brain. Neuron 29:571-581, 2001
    • (2001) Neuron , vol.29 , pp. 571-581
    • Herz, J.1
  • 78
    • 0034682827 scopus 로고    scopus 로고
    • Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
    • Gotthardt M, Trommsdorff M, Nevitt MF, et al: Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 275:25616-25624, 2000
    • (2000) J Biol Chem , vol.275 , pp. 25616-25624
    • Gotthardt, M.1    Trommsdorff, M.2    Nevitt, M.F.3
  • 79
    • 0000180937 scopus 로고    scopus 로고
    • Renal osteodystrophies
    • chapt 51, edited by Brenner BM, Philadelphia, W.B. Saunders Company
    • LLach F, Bover J: Renal osteodystrophies (chapt 51), in The Kidney (6th Ed.), edited by Brenner BM, Philadelphia, W.B. Saunders Company, 2000, pp 2103-2186
    • (2000) The Kidney (6th Ed.) , pp. 2103-2186
    • Llach, F.1    Bover, J.2
  • 80
    • 0003094062 scopus 로고    scopus 로고
    • Vitamin D binding protein
    • chapt 7, edited by Feldman D, Gloeieux FHPJW, San Diego, Academic Press
    • Cooke NE, Haddad JG: Vitamin D binding protein (chapt 7), in Vitamin D, edited by Feldman D, Gloeieux FHPJW, San Diego, Academic Press, 1997, pp 87-101
    • (1997) Vitamin D , pp. 87-101
    • Cooke, N.E.1    Haddad, J.G.2
  • 81
    • 0032918417 scopus 로고    scopus 로고
    • Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
    • Safani FF, Thornton P, Magiera H, et al: Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest 103:239-251, 1999
    • (1999) J Clin Invest , vol.103 , pp. 239-251
    • Safani, F.F.1    Thornton, P.2    Magiera, H.3
  • 83
    • 0035092887 scopus 로고    scopus 로고
    • Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase
    • Zehnder D, Bland R, Williams MC, et al: Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86:888-894, 2001
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 888-894
    • Zehnder, D.1    Bland, R.2    Williams, M.C.3
  • 84
    • 0023890336 scopus 로고
    • The mutants of the vitamin-D-binding protein: More than 120 variants of the GC/DBP system
    • Cleve H, Constans J: The mutants of the vitamin-D-binding protein: More than 120 variants of the GC/DBP system. Vox Sang 54:215-225, 1988
    • (1988) Vox Sang , vol.54 , pp. 215-225
    • Cleve, H.1    Constans, J.2
  • 85
    • 0024458553 scopus 로고
    • Vitamin D binding protein (Gc-globulin)
    • Cooke NE, Haddad JG: Vitamin D binding protein (Gc-globulin). Endocr Rev 10:294-307, 1989
    • (1989) Endocr Rev , vol.10 , pp. 294-307
    • Cooke, N.E.1    Haddad, J.G.2
  • 86
    • 0028866108 scopus 로고
    • Osteomalacia associated with adult Fanconi's syndrome: Clinical and diagnostic features
    • Clarke BL, Wynne AG, Wilson DM, et al: Osteomalacia associated with adult Fanconi's syndrome: Clinical and diagnostic features. Clin Endocrinol (Oxf) 43:479-490, 1995
    • (1995) Clin Endocrinol (Oxf) , vol.43 , pp. 479-490
    • Clarke, B.L.1    Wynne, A.G.2    Wilson, D.M.3
  • 87
    • 0028276469 scopus 로고
    • A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily
    • Lundgren S, Hjalm G, Hellman P, et al: A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily. Exp Cell Res 212:344-350, 1994
    • (1994) Exp Cell Res , vol.212 , pp. 344-350
    • Lundgren, S.1    Hjalm, G.2    Hellman, P.3
  • 88
    • 0024430817 scopus 로고
    • The free hormone hypothesis: A physiologically based mathematical model
    • Mendel CM: The free hormone hypothesis: A physiologically based mathematical model. Endocr Rev 10:232-274, 1989
    • (1989) Endocr Rev , vol.10 , pp. 232-274
    • Mendel, C.M.1
  • 89
    • 0032727633 scopus 로고    scopus 로고
    • Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney
    • Zehnder D, Bland R, Walker EA, et al: Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney. J Am Soc Nephrol 10:2465-2473, 1999
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2465-2473
    • Zehnder, D.1    Bland, R.2    Walker, E.A.3
  • 90
    • 0033624656 scopus 로고    scopus 로고
    • 1alpha-Hydroxylase and the action of vitamin D
    • Hewison M, Zehnder D, Bland R, et al: 1alpha-Hydroxylase and the action of vitamin D. J Mol Endocrinol 25:141-148, 2000
    • (2000) J Mol Endocrinol , vol.25 , pp. 141-148
    • Hewison, M.1    Zehnder, D.2    Bland, R.3
  • 91
    • 0022542094 scopus 로고
    • Uptake of transcobalamin II-bound cobalamin by isolated rat kidney tubule cells
    • Lindemans J, Van Kapel J, Abels J: Uptake of transcobalamin II-bound cobalamin by isolated rat kidney tubule cells. Scand J Clin Lab Invest 46:223-232, 1986
    • (1986) Scand J Clin Lab Invest , vol.46 , pp. 223-232
    • Lindemans, J.1    Van Kapel, J.2    Abels, J.3
  • 92
    • 0031665728 scopus 로고    scopus 로고
    • Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin
    • Nielsen R, Birn H, Moestrup SK, et al: Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin. J Am Soc Nephrol 9:1767-1776, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1767-1776
    • Nielsen, R.1    Birn, H.2    Moestrup, S.K.3
  • 93
    • 0343773228 scopus 로고    scopus 로고
    • Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells
    • Nielsen R, Sorensen BS, Birn H, et al: Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells. J Am Soc Nephrol 12:1099-1106, 2001
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1099-1106
    • Nielsen, R.1    Sorensen, B.S.2    Birn, H.3
  • 94
    • 0035001384 scopus 로고    scopus 로고
    • Studies of vitamin A metabolism in mouse model systems
    • Gottesman ME, Quadro L, Blaner WS: Studies of vitamin A metabolism in mouse model systems. Bioessays 23:409-419, 2001
    • (2001) Bioessays , vol.23 , pp. 409-419
    • Gottesman, M.E.1    Quadro, L.2    Blaner, W.S.3
  • 95
    • 0034676433 scopus 로고    scopus 로고
    • --channel disruption impairs endocytosis in a mouse model for Dent's disease
    • --channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 408:369-373, 2000
    • (2000) Nature , vol.408 , pp. 369-373
    • Piwon, N.1    Gunther, W.2    Schwake, M.3
  • 96
    • 0036139676 scopus 로고    scopus 로고
    • Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome
    • Norden AG, Lapsley M, Igarashi T, et al: Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome. J Am Soc Nephrol 13:125-133, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 125-133
    • Norden, A.G.1    Lapsley, M.2    Igarashi, T.3
  • 98
    • 0021178552 scopus 로고
    • 12) metabolism in the rat: The uptake and intracellular binding of cobalamin and the activity of the cobalamin-dependent enzymes in response to varying cobalamin supply
    • 12) metabolism in the rat: The uptake and intracellular binding of cobalamin and the activity of the cobalamin-dependent enzymes in response to varying cobalamin supply. Clin Sci 67:299-306, 1984
    • (1984) Clin Sci , vol.67 , pp. 299-306
    • Scott, J.S.1    Trenton, A.M.2    Bowman, E.P.3
  • 99
    • 0002931130 scopus 로고
    • 12 concentrations in rat
    • 12 concentrations in rat. Ann Acad Sci Fenn 103:1-91, 1963
    • (1963) Ann Acad Sci Fenn , vol.103 , pp. 1-91
    • Salmi, H.A.1
  • 100
    • 0035321614 scopus 로고    scopus 로고
    • Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease
    • Dierkes J, Domrose U, Bosselmann KP, et al: Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease. J Ren Nutr 11:67-72, 2001
    • (2001) J Ren Nutr , vol.11 , pp. 67-72
    • Dierkes, J.1    Domrose, U.2    Bosselmann, K.P.3
  • 102
    • 46549091809 scopus 로고
    • Cobalamin-binding proteins in human urine: Identification and quantitation
    • Wahlstedt V, Gräsbeck R: Cobalamin-binding proteins in human urine: Identification and quantitation. J Lab Clin Med 106:439-446, 1985
    • (1985) J Lab Clin Med , vol.106 , pp. 439-446
    • Wahlstedt, V.1    Gräsbeck, R.2
  • 103
    • 0035079273 scopus 로고    scopus 로고
    • Transcytosis of retinol-binding protein across renal proximal tubule cells after megalin (gp 330)-mediated endocytosis
    • Marino M, Andrews D, Brown D, et al: Transcytosis of retinol-binding protein across renal proximal tubule cells after megalin (gp 330)-mediated endocytosis. J Am Soc Nephrol 12:637-648, 2001
    • (2001) J Am Soc Nephrol , vol.12 , pp. 637-648
    • Marino, M.1    Andrews, D.2    Brown, D.3
  • 104
    • 0002474191 scopus 로고
    • Functional ultrastructure of the proximal tubule
    • chapt 2, edited by Windhager EE, New York, Oxford University Press
    • Maunsbach AB, Christensen EI: Functional ultrastructure of the proximal tubule (chapt 2), in Handbook of Physiology. Renal Physiology, edited by Windhager EE, New York, Oxford University Press, 1992, pp 41-107
    • (1992) Handbook of Physiology. Renal Physiology , pp. 41-107
    • Maunsbach, A.B.1    Christensen, E.I.2
  • 105
    • 0026542764 scopus 로고
    • Leupeptin and ammonium chloride inhibit intrinsic factor mediated transcytosis of [57Co]cobalamin across polarized renal epithelial cells
    • Ramanujam KS, Seetharam S, Seetharam B: Leupeptin and ammonium chloride inhibit intrinsic factor mediated transcytosis of [57Co]cobalamin across polarized renal epithelial cells. Biochem Biophys Res Commun 182:439-446, 1992
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 439-446
    • Ramanujam, K.S.1    Seetharam, S.2    Seetharam, B.3
  • 106
    • 0027989584 scopus 로고
    • Expression of transcobalamin II mRNA in human tissues and cultured fibroblasts from normal and transcobalamin II-deficient patients
    • Li N, Seetharam S, Rosenblatt DS, et al: Expression of transcobalamin II mRNA in human tissues and cultured fibroblasts from normal and transcobalamin II-deficient patients. Biochem J 301:585-590, 1994
    • (1994) Biochem J , vol.301 , pp. 585-590
    • Li, N.1    Seetharam, S.2    Rosenblatt, D.S.3
  • 107
  • 108
    • 0037016726 scopus 로고    scopus 로고
    • Megalin deficiency offers protection from renal aminoglycoside accumulation
    • Schmitz C, Hilpert J, Jacobsen C, et al: Megalin deficiency offers protection from renal aminoglycoside accumulation. J Biol Chem 277:618-622, 2002
    • (2002) J Biol Chem , vol.277 , pp. 618-622
    • Schmitz, C.1    Hilpert, J.2    Jacobsen, C.3
  • 109
    • 0016269396 scopus 로고
    • Renal parenchymal accumulation of aminoglycoside antibiotics in rats
    • Luft FC, Klett SA: Renal parenchymal accumulation of aminoglycoside antibiotics in rats. J Infect Dis 130:656-659, 1974
    • (1974) J Infect Dis , vol.130 , pp. 656-659
    • Luft, F.C.1    Klett, S.A.2
  • 110
    • 0020660697 scopus 로고
    • Transport of gentamicin in rat proximal tubule
    • Wedeen RP, Batuman V, Cheeks C, et al: Transport of gentamicin in rat proximal tubule. Lab Invest 48:212-223, 1983
    • (1983) Lab Invest , vol.48 , pp. 212-223
    • Wedeen, R.P.1    Batuman, V.2    Cheeks, C.3
  • 111
    • 0018290957 scopus 로고
    • Evidence for luminal uptake of gentamicin in the perfused rat kidney
    • Collier VU, Lietman PS, Mitch WE: Evidence for luminal uptake of gentamicin in the perfused rat kidney. J Pharmacol Exp Ther 210:247-251, 1979
    • (1979) J Pharmacol Exp Ther , vol.210 , pp. 247-251
    • Collier, V.U.1    Lietman, P.S.2    Mitch, W.E.3
  • 113
    • 0027997238 scopus 로고
    • Antibiotic-related nephrotoxicity
    • Kaloyanides G.J. Antibiotic-related nephrotoxicity. Nephrol Dial Transplant 9(Suppl 4):130-134, 1994
    • (1994) Nephrol Dial Transplant , vol.9 , pp. 130-134
    • Kaloyanides, G.J.1
  • 114
    • 0030745876 scopus 로고    scopus 로고
    • Cell biology of aminoglycoside nephrotoxicity: Newer aspects
    • Molitoris BA: Cell biology of aminoglycoside nephrotoxicity: Newer aspects. Curr Opin Nephrol Hypertens 6:384-388, 1997
    • (1997) Curr Opin Nephrol Hypertens , vol.6 , pp. 384-388
    • Molitoris, B.A.1
  • 116
    • 0018691553 scopus 로고
    • Autoradiography of gentamicin uptake by the rat proximal tubule cell
    • Silverblatt FJ, Kuehn C: Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int 15:335-345, 1979
    • (1979) Kidney Int , vol.15 , pp. 335-345
    • Silverblatt, F.J.1    Kuehn, C.2
  • 118
    • 0019959284 scopus 로고
    • Identification of the aminoglycoside binding site in rat renal brush border membranes
    • Sastrasinh M, Knauss TC, Weinberg JM, et al: Identification of the aminoglycoside binding site in rat renal brush border membranes. J Pharmacol Exp Ther 222:350-358, 1982
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 350-358
    • Sastrasinh, M.1    Knauss, T.C.2    Weinberg, J.M.3
  • 119
    • 0021335817 scopus 로고
    • Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity
    • Humes HD, Sastrasinh M, Weinberg JM: Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J Clin Invest 73:134-147, 1984
    • (1984) J Clin Invest , vol.73 , pp. 134-147
    • Humes, H.D.1    Sastrasinh, M.2    Weinberg, J.M.3
  • 120
    • 0018646906 scopus 로고
    • Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney
    • Schacht J: Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney. Arch Otorhinolaryngol 1224:129-134, 1979
    • (1979) Arch Otorhinolaryngol , vol.1224 , pp. 129-134
    • Schacht, J.1
  • 121
    • 0033031685 scopus 로고    scopus 로고
    • Ultrastructural localization of megalin in the rat cochlear duct
    • Mizuta K, Saito A, Watanabe T, et al: Ultrastructural localization of megalin in the rat cochlear duct. Hear Res 129:83-91, 1999
    • (1999) Hear Res , vol.129 , pp. 83-91
    • Mizuta, K.1    Saito, A.2    Watanabe, T.3
  • 122
    • 0034642297 scopus 로고    scopus 로고
    • Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
    • Wang SS, Devuyst O, Courtoy PJ, et al: Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet 9:2937-2945, 2000
    • (2000) Hum Mol Genet , vol.9 , pp. 2937-2945
    • Wang, S.S.1    Devuyst, O.2    Courtoy, P.J.3
  • 123
    • 0032493276 scopus 로고    scopus 로고
    • C1C-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells
    • Gunther W, Luchow A, Cluzeaud F, et al: C1C-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc Natl Acad Sci USA 95:8075-8080, 1998
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8075-8080
    • Gunther, W.1    Luchow, A.2    Cluzeaud, F.3
  • 124
    • 0035001610 scopus 로고    scopus 로고
    • An endocytosis defect as a possible cause of proteinuria in polycystic kidney disease
    • Obermuller N, Kranzlin B, Blum WE, et al: An endocytosis defect as a possible cause of proteinuria in polycystic kidney disease. Am J Physiol (Renal Physiol) 280:F244-F253, 2001
    • (2001) Am J Physiol (Renal Physiol) , vol.280 , pp. F244-F253
    • Obermuller, N.1    Kranzlin, B.2    Blum, W.E.3
  • 125
    • 0034791132 scopus 로고    scopus 로고
    • Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells
    • Lebeau C, Arlt ME, Schmeiser HH, et al: Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. Kidney Int 60:1332-1342, 2001
    • (2001) Kidney Int , vol.60 , pp. 1332-1342
    • Lebeau, C.1    Arlt, M.E.2    Schmeiser, H.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.