Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo

Toxicology Letters

Volumn 212, Issue 2, 2012, Pages 91-96

  Onodera, Akira ^a,e   Tani, Miyuki ^a   Michigami, Toshimi ^b   Yamagata, Masayo ^b,c   Min, Kyong Son ^c   Tanaka, Keiichi ^a,c   Nakanishi, Tsuyoshi ^a,f   Kimura, Tomoki ^d   Itoh, Norio ^a  

^a OSAKA UNIVERSITY   (Japan)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c OSAKA OHTANI UNIVERSITY   (Japan)

^d SETSUNAN UNIVERSITY   (Japan)

^e KOBE GAKUIN UNIVERSITY   (Japan)

^f GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cadmium; Lrp2; Lrpap1; Megalin; Metallothionein; SRAP

Indexed keywords

CADMIUM; GLYCOPROTEIN; MEGALIN; METALLOTHIONEIN; PROTEIN LRPAP1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; GLOMERULUS; IN VIVO STUDY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MOLECULAR WEIGHT; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; ENDOCYTOSIS; KIDNEY; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; LIGANDS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; MALE; METALLOTHIONEIN; MICE; MICE, INBRED ICR;

ANIMALIA; MUS;

EID: 84861748499     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.05.012     Document Type: Article

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