Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney

Kidney International

Volumn 58, Issue 4, 2000, Pages 1523-1533

  Zhai, Xiao Yue ^a,b,c   Nielsen, Rikke ^a,b,c   Birn, Henrik ^a,b,c   Drumm, Karina ^a,b,c   Mildenberger, Sigrid ^a,b,c   Freudinger, Ruth ^a,b,c   Moestrup, Søren K ^a,b,c   Verroust, Pierre J ^a,b,c   Christensen, Erik I ^a,b,c   Gekle, Michael ^a,b,c  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c Section of Radiology   (France)

Author keywords

Albumin binding proteins; Endocytosis; Glycoprotein receptor; Renal protein uptake; Tubular reabsorption; Vitamin B12

Indexed keywords

ALBUMIN; ANTISENSE OLIGONUCLEOTIDE; CELL RECEPTOR; CUBILIN; INTRINSIC FACTOR; MEGALIN; PROTEIN ANTIBODY; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; LYSOSOME; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

EID: 0033802618     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00314.x     Document Type: Article

References (42)

1. Megalin/gp 330 mediates uptake of albumin in renal proximal tubule
2. Complete cloning and sequencing of rat gp330/'megalin,' a distinctive member of the low density lipoprotein receptor gene family
3. Characterization and distribution of albumin binding protein in normal rat kidney
4. Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor
5. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP)
6. Membrane receptors for endocytosis in the renal proximal tubule
7. Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein
8. The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
9. Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac
10. Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dog-ileum: Distribution of intracellular receptor during cell maturation
11. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
12. Myeloma light chains are ligands for cubilin (gp280)
13. Idiopathic chronic megaloblastic anemia in children
14. Selective vitamin B 12 malabsorption and proteinuria in young people
15. Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption
16. Megalin antagonizes activation of the parathyroid hormone receptor
17. Evidence for an essential role of megalin in transepithelial transport of retinol
18. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D 3
19. Essential role of megalin in renal proximal tubule for vitamin homeostasis
20. Electrical properties of cultured renal tubular cells (OK) grown in confluent monolayers
21. Parathyroid hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein
22. Characteristics of albumin binding to opossum kidney cells and identification of potential receptors
23. Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase
24. Functional characterization of albumin binding to the apical membrane of OK cells
25. Albumin endocytosis in OK cells: Dependence on actin and microtubules and regulation by protein kinases
26. Receptor-mediated endocytosis of albumin in cultured opossum kidney cells: A model for proximal tubular protein reabsorption
27. Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase plasminogen activator inhibitor type-1 complex: Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptorbound complexes
28. Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes
29. Internalization and recycling of glycoprotein 280 in epithelial cells of yolk sac
30. Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cells
31. 2+ and cAMP
32. Protein measurement with the folin phenol reagent
33. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
34. Functional domains of the receptor-associated protein (RAP)
35. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding
36. Binding of I-125-1abelled albumin by isolated rat renal brush-border membrane vesicles: Evidence for uptake and internalization process
37. Beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
38. The Heymann nephritis antigenic complex: Megalin (gp330) and RAP
39. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B 12 homeostasis
40. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs
41. The alpha 2-macroglobulin receptor and epithelial glycoprotein-330: Two giant receptors mediating endocytosis of multiple ligands
42. Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit